Codein

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: Codein
• 英文别名: 4,5α-epoxy-3-methoxy-17-methyl-morphin-7-en-6α-ol；(4R,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.37
• InChiKey: OROGSEYTTFOCAN-AHYHBEEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 6-Monoacetylmorphine derivatives useful in immunoassay
  申请人：Ghoshal Mitali

  公开号：US20070142628A1

  公开（公告）日：2007-06-21

  Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.

  6-单乙酰吗啡（6-MAM）类似物如下所述。这些包括在分子的C-3位置、C-6位置或去甲位置进行衍生的类似物。这些类似物允许进行以活化酯等功能团终止的连接剂的详细说明，这些功能团对于将分子附着到其他实体（如蛋白质、多糖和报告团）非常有用。
• 6-MONOACETYLMORPHINE DERIVATIVES USEFUL IN IMMUNOASSAY
  申请人：Ghoshal Mitali

  公开号：US20070191595A1

  公开（公告）日：2007-08-16

  Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.

  描述了6-单乙酰吗啡（6-MAM）的类似物。这些包括在分子的C-3位置，C-6位置或nor位置衍生的类似物。这些类似物允许通过以活化酯为终止的连接剂进行扩展，这些功能基团有助于将分子连接到其他实体，如蛋白质、多糖和报告基团。
• COMPOSITIONS AND METHODS THEREOF
  申请人：EXCIVA GmbH

  公开号：US20210228508A1

  公开（公告）日：2021-07-29

  Compounds of Formula I or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided.
• US7238791B1
  申请人：——

  公开号：US7238791B1

  公开（公告）日：2007-07-03
• US7465797B2
  申请人：——

  公开号：US7465797B2

  公开（公告）日：2008-12-16