4,5α-epoxy-3-methoxy-17-methyl-morphin-7-en-6α-ol | 76-57-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 4,5α-epoxy-3-methoxy-17-methyl-morphin-7-en-6α-ol
• 英文别名: Codein；(-)-codeine；codeine；(4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
• CAS: 76-57-3；509-64-8；7235-41-8；16206-70-5；27067-72-7；64520-25-8；70982-46-6
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.37
• InChiKey: OROGSEYTTFOCAN-OJHGLTBHSA-N

物化性质

• 熔点：
  98-102 °C(Solv: ethyl ether (60-29-7))
• 沸点：
  462.0±45.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险品标志：
  F,T
• 危险类别码：
  R23/24/25,R39/23/24/25,R11
• WGK Germany：
  1
• 海关编码：
  2939110012
• 危险品运输编号：
  UN 1230 3/PG 2

文献信息

• CONVERSION OF THEBAINE TO MORPHINE DERIVATIVES
  申请人：Carroll Robert James

  公开号：US20090005563A1

  公开（公告）日：2009-01-01

  The present invention provides methods for the conversion of thebaine to a morphine derivative, such as hydrocodone. Novel ketal intermediates of the conversion are provided. A one-pot procedure for the conversion comprises treating thebaine with an acid in the presence of a metal catalyst.

  本发明提供了将吗啡碱转化为吗啡衍生物（如羟考酮）的方法。提供了该转化的新型缩酮中间体。该转化的一锅法包括在金属催化剂存在下用酸处理吗啡碱。
• Papaver somniferum with high concentration of codeine
  申请人：Tasmanian Alkaloids Pty. Ltd.

  公开号：US10791691B2

  公开（公告）日：2020-10-06

  A poppy straw of Papaver somniferum, wherein the poppy straw includes codeine constituting about 40% by weight or greater of an alkaloid combination.

  罂粟的罂粟秆，其中罂粟秆包括可待因，占生物碱组合重量的 40% 或更多。
• Papaver somniferum strain with high concentration of thebaine
  申请人：Tasmanian Alkaloids Pty. Ltd.

  公开号：US10760090B2

  公开（公告）日：2020-09-01

  The present invention is directed to an improved poppy straw, concentrate of poppy straw and opium of Papaver somniferum for the production of thebaine containing little or no oripavine, codeine or morphine. The present invention also provides plants, stands and seeds of Papaver somniferum and methods for the production of thebaine.

  本发明涉及一种改良的罂粟秸秆、罂粟秸秆浓缩物和苏木鸦片，用于生产含少量或不含奥替巴因、可待因或吗啡的苏木碱。本发明还提供了罂粟的植物、支架和种子以及生产蒂巴因的方法。
• PAPAVER SOMNIFERUM WITH HIGH CONCENTRATION OF CODEINE
  申请人：Fist Anthony J.

  公开号：US20100234600A1

  公开（公告）日：2010-09-16

  The present invention is directed to an improved poppy straw, concentrate of poppy straw and opium of Papaver somniferum for the production of codeine containing little or no oripavine, morphine or thebaine. The present invention also provides plants, stands and seeds of Papaver somniferum and methods for the production of codeine.
• STABLE ORAL PHARMACEUTICAL COMPOSITION
  申请人：HYPERMARCAS S.A.

  公开号：US20160317662A1

  公开（公告）日：2016-11-03

  The present invention relates to a stable oral pharmaceutical composition for relieving moderate to intense pain, related to trauma (sprains, dislocations, contusions, distensions, fractures), postoperative and post-tooth extraction conditions, neuralgia, lumbago, joint pain and similar conditions. Such composition comprises (a) dipyrone, its free acid or pharmacologically acceptable salts thereof, (b) codeine (7,8-dihydro-4,5-epoxy-3-methoxy-17-methyl morfinane-6-ol) or pharmacologically acceptable salts, (c) polyethylene glycol and (d) pharmaceutically acceptable excipients, in small amounts. Particularly, the present invention relates to a coated tablet.