2,2-dimethyl-N-hydroxyethyl-1,3-oxazolidin | 80136-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2,2-dimethyl-N-hydroxyethyl-1,3-oxazolidin
• 英文别名: 2,2-dimethyl-3-hydroxyethyl-1,3-oxazolidine；2-(2,2-dimethyl-oxazolidin-3-yl)-ethanol；2,2-dimethyl-3-(2-hydroxyethyl)-oxazolidine；2-(2,2-dimethyl-1,3-oxazolidin-3-yl)ethanol
• CAS: 80136-05-6
• 化学式: C₇H₁₅NO₂
• 分子量: 145.202
• InChiKey: WIBROAYAWBWRHP-UHFFFAOYSA-N

物化性质

• 沸点：
  215.2±25.0 °C(Predicted)
• 密度：
  1.006±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-N-hydroxyethyl-1,3-oxazolidin 、 2-(4-propyl-heptyl)-oxirane 在 potassium tert-butylate 、 盐酸 、 水 、 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 7.0h， 以90%的产率得到1-[2-(2-hydroxy-ethylamino)-ethoxy]-6-propyl-nonan-2-ol
  参考文献：
  名称：

  WO2007/91009

  摘要：

  公开号：
• 作为产物：
  描述：

  二乙醇胺 、 丙酮 以 甲苯 为溶剂， 以200 g的产率得到2,2-dimethyl-N-hydroxyethyl-1,3-oxazolidin
  参考文献：
  名称：

  一种双噁唑烷潜固化剂及其制备方法

  摘要：

  一种双噁唑烷潜固化剂及其制备方法，其由符合通式（II）的3‑羟乙基‑1,3‑噁唑烷和二元酯酯交换反应所得到，其特点是分子结构中含有两个噁唑烷环，且噁唑烷取代基上的活泼羟基被隐藏，密封条件下储存稳定性好；开封使用时遇湿气生成更多的活泼基团，进而与异氰酸酯基发生扩链交联反应，形成三维网状结构。该类双噁唑烷潜固化剂应用于单组分聚氨酯材料中，不仅可以从源头上避免体系在固化过程中产生气泡，还可大幅提高聚氨酯制品的使用性能。

  公开号：

  CN115353494A

文献信息

• Ambient hydrocurable coating and adhesives compositions
  申请人：Rohm and Haas Company

  公开号：US04299867A1

  公开（公告）日：1981-11-10

  The present invention is concerned with, as a hydrocurable composition, a mixture of an oxazolidine-functional polymer and a compound of a monomeric or polymeric character having a plurality of acryloxy groups. The first-mentioned polymer contains a plurality of pendant groups containing 2,2-dialkyl oxazolidine groups. The mixture of these two components can be stored under anhydrous conditions in a closed container without co-reaction so that a one-pot or one-package composition can be made up with many conventional ingredients of coating compositions other than aqueous components and stored without gelling until the time for application when the composition may be applied at ambient temperature and humidity whereupon reaction between the main two components mentioned above occurs in the film deposited and the film set up.

  本发明涉及一种水固化组合物，它是一种含有氧氮环的聚合物和具有多个丙烯氧基基团的单体或聚合物化合物的混合物。前述的聚合物含有多个侧链基团，其中包含2,2-二烷基氧氮环基团。这两种组分的混合物可以在无水条件下存储在密封容器中，而不会发生共反应，因此可以制备出一种一锅或一包式组合物，并且可以将其与许多传统的涂料组分（除水分外）一起存储，直到使用时才凝胶化。在应用时，该组合物可以在室温和湿度下涂覆，并在沉积的膜中发生上述两种主要组分之间的反应，从而形成膜。
• Hydrocurable ambient curing polyepoxide coating and adhesive
  申请人：Rohm and Haas Company

  公开号：US04308356A1

  公开（公告）日：1981-12-29

  Resin-forming polyepoxides are mixed with polyoxazolidinyl compounds or polymers containing pendant oxazolidinyl groups in which the carbon atom in the 2-position of the heterocyclic ring is substituted with saturated hydrocarbon groups, such as dialkyl, or with an alkylene group forming a saturated ring with the carbon atom in the 2-position of the oxazolidinyl ring to form, in the absence of water, a stable composition which can be stored in closed containers for months without undergoing gelation. When such compositions are spread into films and the films exposed to moisture at ambient temperature, e.g., to ambient air having a relative humidity of at least 20% and temperature of about 15.degree. to 25.degree. C., the polymer serves to react with and cure the polyepoxide.

  将形成树脂的聚环氧化物与含有氧杂环分子中的偏挂氧杂环基团的聚合物或含有饱和碳氢基团的二烷基等物质混合，其中杂环环上的2-位碳原子被取代。或者使用与氧杂环环上的2-位碳原子形成饱和环的烷基环取代。在无水的情况下，形成一种稳定的混合物，可以密闭储存数月而不发生凝胶化。当这种混合物涂敷成薄膜并暴露在潮湿的环境中，例如相对湿度至少为20％，温度约为15℃至25℃的环境空气中，聚合物会与并固化聚环氧化物。
• Ambient hydrocurable coating compositions
  申请人：Rohm and Haas Company

  公开号：US04373008A1

  公开（公告）日：1983-02-08

  The present invention is concerned with, as a hydrocurable composition, a mixture of an oxazolidine-functional polymer and a compound of a monomeric or polymeric character having a plurality of acryloxy groups. The first-mentioned polymer contains a plurality of pendant groups containing 2,2,-dialkyl oxazolidine groups. The mixture of these two components can be stored under anhydrous conditions in a closed container without co-reaction so that a one-pot or one-package composition can be made up with many conventional ingredients of coating compositions other than aqueous components and stored without gelling until the time for application when the composition may be applied at ambient temperature and humidity whereupon reaction between the main two components mentioned above occurs in the film deposited and the film set up.

  本发明涉及一种水固化组合物，它是由含有2,2-二烷基噁唑啉基团的官能化聚合物和具有多个丙烯氧基基团的单体或聚合物化合物的混合物组成。第一种聚合物含有多个垂直基团，其中包含2,2-二烷基噁唑啉基团。这两种组分的混合物可以在无水条件下存储在封闭容器中，而不会发生共反应，因此可以使用许多传统的涂料成分制成一锅或一包式组合物，并在不凝胶的情况下存储，直到应用时可以在环境温度和湿度下应用该组合物，然后在沉积膜中发生上述两种主要组分之间的反应，并形成膜。
• Preparation of Delmopinol
  申请人：Comely Alexander

  公开号：US20090036677A1

  公开（公告）日：2009-02-05

  It comprises a preparation process of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by submitting the compound of formula (II) where R 1 and R 2 are the same or different, independently selected from the group consisting of H, (C 1 -C 6 )-alkyl or, alternatively, R 1 and R 2 form, together with the carbon atom to which they are attached, a (C 5 -C 6 )-cycloalkyl radical; and R 3 is a radical selected from the group consisting of CF 3 , (C 1 -C 4 )-alkyl, phenyl, and phenyl mono- or disubstituted by a radical selected from the group consisting of (C 1 -C 4 )-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process.

  该发明涉及一种制备德莫匹诺或其药学上可接受的盐和/或其溶剂化物的制备过程，通过将式（II）的化合物提交至去保护和环化反应，其中R1和R2相同或不同，独立地选自H，（C1-C6）-烷基或者，R1和R2与它们连接的碳原子一起形成（C5-C6）-环烷基基团; R3是从CF3，（C1-C4）-烷基，苯基和苯基单取代或双取代基团中选择的基团，所述基团的取代基是从（C1-C4）-烷基，卤素和硝基中选择的基团。该过程有助于在工业规模上制备德莫匹诺或其盐。式（II）的化合物是新的，也是本发明的一部分，以及其制备过程和所述制备过程的其他新中间体。
• Preparation of delmopinol
  申请人：Sinclair Pharmaceuticals Limited

  公开号：US07893258B2

  公开（公告）日：2011-02-22

  It comprises a preparation process of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by submitting the compound of formula (II) where R1 and R2 are the same or different, independently selected from the group consisting of H, (C1-C6)-alkyl or, alternatively, R1 and R2 form, together with the carbon atom to which they are attached, a (C5-C6)-cycloalkyl radical; and R3 is a radical selected from the group consisting of CF3, (C1-C4)-alkyl, phenyl, and phenyl mono- or disubstituted by a radical selected from the group consisting of (C1-C4)-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process.

  该方法包括通过将式（II）化合物进行去保护和环化反应来制备delmopinol或其药学上可接受的盐和/或溶剂化物的制备过程，其中R1和R2相同或不同，独立地选自H，（C1-C6）-烷基或者，R1和R2与它们所连接的碳原子一起形成（C5-C6）-环烷基基团；R3是选自CF3，（C1-C4）-烷基，苯基以及苯基单取代或双取代的基团，所述基团选自（C1-C4）-烷基，卤素和硝基。该方法有助于在工业规模下制备delmopinol或其盐。式（II）化合物是新的并且也是本发明的一部分，以及其制备过程和该制备过程的其他新中间体。