thebaine hydrochloride | 850-57-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: thebaine hydrochloride
• 英文别名: Thebainhydrochloridmonohydrat；thebaine；Thebain*HCl；N-nororipavine hydrochloride；(5α)-6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan hydrochloride；4,5α-epoxy-3,6-dimethoxy-17-methyl-morphina-6,8(14)-diene; hydrochloride；Thebain; Hydrochlorid；thebainium chloride；(4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline;hydron;chloride
• CAS: 850-57-7
• 化学式: C₁₉H₂₂NO₃*Cl
• 分子量: 347.842
• InChiKey: KTFNLKDWNNDGLZ-JFYDKBSOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.85
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  30.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  thebaine hydrochloride 在 sodium tetrahydroborate 、 三氟乙酸 作用下， 生成 neodihydrothebaine
  参考文献：
  名称：

  Neodihydrothebaine 和 bractazonine，罂粟的两种二苯并[d,f]azonine 生物碱

  摘要：

  从罂粟中分离出两种新的二苯并[d,f] azonine 生物碱neodihydrothebaine 和bractazonine。讨论了它们可能从蒂巴因生物合成。两种新生物碱的结构均通过合成证明。还制备了异构二苯并[d，f]氮杂化合物。

  DOI：

  10.1016/s0031-9422(00)82630-8

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Cr: MVol.B, 339, page 747 - 750
  作者：

  DOI：——

  日期：——
• Plugge, P. C., Archiv der Pharmazie, 1887, vol. 225, p. 793 - 811
  作者：Plugge, P. C.

  DOI：——

  日期：——
• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.