(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phosphonic acid diethyl ester | 1356543-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phosphonic acid diethyl ester
• 英文别名: diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-yl-phosphonate；5-diethoxyphosphoryl-1H-pyrimidine-2,4-dione
• CAS: 1356543-64-0
• 化学式: C₈H₁₃N₂O₅P
• 分子量: 248.175
• InChiKey: KQZLJBKFOGTFTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  亚磷酸二乙酯 、 尿嘧啶 在 manganese(III) triacetate dihydrate 、 溶剂黄146 作用下， 反应 3.0h， 以88%的产率得到(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phosphonic acid diethyl ester
  参考文献：
  名称：

  An efficient synthesis of 5-phosphorylated uracil derivatives: oxidative cross-coupling between uracil and dialkyl phosphites

  摘要：

  An efficient synthesis of 5-phosphorylated uracil derivatives has been carried out via an oxidative cross-coupling reaction between uracil derivatives and dialkyl phosphites in the presence of Mn(OAc)(3) in AcOH. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.01.056

文献信息

• Polyethylene Glycol–Promoted Dialkyl, Aryl/Heteroaryl Phosphonates
  作者：K. Reddi Mohan Naidu、E. Dadapeer、C. Bhupendra Reddy、A. Janardhan Rao、C. Suresh Reddy、C. Naga Raju

  DOI：10.1080/00397911.2010.518279

  日期：2011.12.1

  Abstract A new, straightforward polyethylene glycol–promoted method for Michaelis–Arbuzov rearrangement has been described.

  摘要描述了一种新的、直接的聚乙二醇促进的 Michaelis-Arbuzov 重排方法。
• An efficient synthesis of 5-phosphorylated uracil derivatives: oxidative cross-coupling between uracil and dialkyl phosphites
  作者：Se Hee Kim、Sung Hwan Kim、Cheol Hee Lim、Jae Nyoung Kim

  DOI：10.1016/j.tetlet.2013.01.056

  日期：2013.3

  An efficient synthesis of 5-phosphorylated uracil derivatives has been carried out via an oxidative cross-coupling reaction between uracil derivatives and dialkyl phosphites in the presence of Mn(OAc)(3) in AcOH. (c) 2013 Elsevier Ltd. All rights reserved.