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6-Methoxy-7-[(2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methoxy]chromen-2-one | 1313436-24-6

中文名称
——
中文别名
——
英文名称
6-Methoxy-7-[(2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methoxy]chromen-2-one
英文别名
6-methoxy-7-[(2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methoxy]chromen-2-one
6-Methoxy-7-[(2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methoxy]chromen-2-one化学式
CAS
1313436-24-6
化学式
C18H22O6
mdl
——
分子量
334.369
InChiKey
HQUJCPGOQUFMOO-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.7
  • 重原子数:
    24
  • 可旋转键数:
    4
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.5
  • 拓扑面积:
    63.2
  • 氢给体数:
    0
  • 氢受体数:
    6

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为产物:
    参考文献:
    名称:
    Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
    摘要:
    Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 mu M, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 mu M, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs. (C) 2013 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmcl.2013.12.104
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文献信息

  • Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
    作者:A. Garro Hugo、M. Manzur Jimena、M. Ciuffo Gladys、E. Tonn Carlos、R. Pungitore Carlos
    DOI:10.1016/j.bmcl.2013.12.104
    日期:2014.2
    Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 mu M, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 mu M, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs. (C) 2013 Elsevier Ltd. All rights reserved.
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