4-tert-butoxycarbonylamino-5-methyl-hexanoic acid | 1190441-57-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-tert-butoxycarbonylamino-5-methyl-hexanoic acid
• 英文别名: 4-(Boc-amino)-5-methylhexanoic acid；5-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid
• CAS: 1190441-57-6
• 化学式: C₁₂H₂₃NO₄
• 分子量: 245.319
• InChiKey: TUFIBOHQJUSMKX-UHFFFAOYSA-N

物化性质

• 沸点：
  383.3±25.0 °C(Predicted)
• 密度：
  1.046±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-Boc-L-缬氨酸 、 丙烯酸 在 对苯二腈 、 菲 作用下， 以 水 、 乙腈 为溶剂， 反应 8.17h， 以57%的产率得到4-tert-butoxycarbonylamino-5-methyl-hexanoic acid
  参考文献：
  名称：

  SET-光化学脱羧羧酸生成的缺电子烯烃与烷基自由基的分子间和分子内加成反应，是一种温和高效的制备γ-氨基酸和大环内酯的方法

  摘要：

  由游离羧酸的SET光化学脱羧反应产生的烷基自由基的分子间和分子内加成反应是在温和条件下进行的，作为形成N -Bocγ-氨基酸和大环内酯的有效途径的一部分。

  DOI：

  10.1021/ol9019277

文献信息

• MACROCYCLE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE)
  申请人：Baxter W. Ellen

  公开号：US20070232630A1

  公开（公告）日：2007-10-04

  The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

  本发明涉及大环衍生物，含有它们的药物组合物以及它们在治疗阿尔茨海默病（AD）及相关疾病中的应用。本发明的化合物是β-分泌酶的抑制剂，也被称为β-位点裂解酶和BACE、BACE1、Asp2和memapsin2。
• Radical addition to acrylonitrile via catalytic photochemical decarboxylation of aliphatic carboxylic acids
  作者：Yasuharu Yoshimi、Sonoka Washida、Yoshiki Okita、Keisuke Nishikawa、Kousuke Maeda、Shota Hayashi、Toshio Morita

  DOI：10.1016/j.tetlet.2013.06.020

  日期：2013.8

  Photoinduced electron transfer (PET)-promoted decarboxylation of aliphatic carboxylic acids using catalytic amounts of an arene and electron-acceptor (>2.5 mol %) was found to proceed efficiently to give adducts even when only 1 equiv of acrylonitrile was employed. The use of catalytic quantities of the arene and electron-acceptor demonstrates that the yield of the adduct is strongly influenced by

  发现即使仅使用1当量的丙烯腈，使用催化量的芳烃和电子受体（＞ 2.5mol％）也能有效地进行光诱导电子转移（PET）促进的脂肪族羧酸的脱羧，以产生加合物。催化量的芳烃和电子受体的使用表明，加合物的收率受到反电子从电子受体的自由基阴离子转移至自由基中间体1的效率的强烈影响。
• [EN] 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE)<br/>[FR] DERIVES DE 2-AMINO-QUINAZOLINE UTILES EN TANT QU'INHIBITEURS DE B-SECRETASE (BACE)
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2006024932A1

  公开（公告）日：2006-03-09

  The present invention is directed to novel 2-amino-3,4-dihydro­quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ß-secretase, also known as ß-site cleaving enzyme and BACE.

  本发明涉及新型2-氨基-3,4-二氢喹唑啉衍生物，包含它们的药物组合物以及其在治疗阿尔茨海默病（AD）和相关疾病中的用途。该发明的化合物是ß-分泌酶抑制剂，也称为ß-位点裂解酶和BACE。
• Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)
  申请人：Bischoff Paul Francois

  公开号：US20060178383A1

  公开（公告）日：2006-08-10

  The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.

  本发明涉及新型2-氨基-3,4-二氢喹唑啉衍生物、含有它们的制药组合物以及它们在治疗阿尔茨海默病（AD）和相关疾病中的应用。本发明的化合物是β-秘鲁酶的抑制剂，也称为β-位点裂解酶和BACE。
• NOVEL 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE)
  申请人：Baxter E. Ellen

  公开号：US20070259898A1

  公开（公告）日：2007-11-08

  The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

  本发明涉及新颖的2-氨基-3,4-二氢-吡啶[3,4-d]嘧啶衍生物，含有它们的制药组合物以及它们在治疗阿尔茨海默病（AD）和相关疾病中的应用。本发明的化合物是β-分泌酶的抑制剂，也称为β-位点剪切酶和BACE，BACE1，Asp2和memapsin2。