8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride | 1457983-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride
• 英文别名: G-749 hydrochloride；8-bromo-2-[(1-methylpiperidin-4-yl)amino]-4-(4-phenoxyanilino)-6H-pyrido[4,3-d]pyrimidin-5-one;hydrochloride
• CAS: 1457983-33-3
• 化学式: C₂₅H₂₅BrN₆O₂*ClH
• 分子量: 557.877
• InChiKey: UDYYCTJUUMIMHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.54
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  91.4
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  8-溴-2-[(1-甲基-4-哌啶基)氨基]-4-[(4-苯氧基苯基)氨基]吡啶并[4,3-D]嘧啶-5(6H)-酮 以 乙醇 、 水 、 异丙醇 为溶剂， 反应 5.0h， 以1.85 g的产率得到8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride
  参考文献：
  名称：

  CRYSTAL POLYMORPH OF 8-BROMO-2-(1-METHYLPIPERIDIN-4-YLAMINO)-4-(4-PHENOXYPHENYLAMINO)PYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE HYDROCHLORIDE AND METHOD FOR PREPARING SAME

  摘要：

  An embodiment relates to a crystal polymorph of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3 -d]pyrimidin-5 (6H)-one hydrochloride which can effectively suppress FLT3 and has excellent stability even in a high temperature and humid environment, and a method for preparing same.

  公开号：

  US20210292322A1

文献信息

• [EN] SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS<br/>[FR] COMPOSÉS DE PYRIDOPYRIMIDINE SUBSTITUÉE ET LEUR UTILISATION COMME INHIBITEURS DE FLT3
  申请人：GENOSCO

  公开号：WO2013142382A1

  公开（公告）日：2013-09-26

  Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

  公开了化学式（I）的化合物和抑制激酶（包括脾酪氨酸激酶）的方法。还公开了通过向受试者施用化学式（I）的化合物的治疗有效量来治疗激酶介导的疾病或病状的方法。
• SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS
  申请人：Oscotec, Inc.

  公开号：US20130274274A1

  公开（公告）日：2013-10-17

  Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

  公式（I）的化合物和抑制激酶的方法，包括脾酪氨酸激酶。还公开了通过向受试者投与公式（I）的化合物的治疗有效量来治疗激酶介导疾病或状况的方法。
• PYRIDOPYRIMIDINONE DERIVATIVES FOR USE AS AXL INHIBITORS
  申请人：Oscotec Inc.

  公开号：EP3814350A1

  公开（公告）日：2021-05-05
• EP3842434A4
  申请人：——

  公开号：EP3842434A4

  公开（公告）日：2022-06-08
• US8877763B2
  申请人：——

  公开号：US8877763B2

  公开（公告）日：2014-11-04