exo-7-oxabicyclo[2.2.1]hept-4-ene-2,3-dicarboximide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: exo-7-oxabicyclo[2.2.1]hept-4-ene-2,3-dicarboximide
• 英文别名: 3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione；exo-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide；7-oxabicyclo[2.2.1]heptene-exo-2,3-dicarboxylic imide；3,6-endoxo-Δ⁴-tetrahydrophthalide；7-oxabicyclo[2.2.1]-5-heptene-2,3-dicarboximide；10-Oxa-4-azatricyclo[5.2.1.0^{2,6}^]dec-8-ene-3,5-dione；(3aR,4S,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-epoxyisoindole-1,3-dione
• 化学式: C₈H₇NO₃
• 分子量: 165.148
• InChiKey: BSEKZMOBPPOFFB-FBXFSONDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  exo-7-oxabicyclo[2.2.1]hept-4-ene-2,3-dicarboximide 在 二氯甲烷 、 溴 作用下， 生成 5ξ,6ξ-dibromo-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione
  参考文献：
  名称：

  cis-Addition in the Bromination of Bicyclic Olefins. The Structure and Stereochemistry of the Dibromides of exo-cis-3,6-Endoxo-Δ⁴-tetrahydrophthalic Anhydride and endo-cis-3,6-Endomethylene-Δ⁴-tetrahydrophthalic Anhydride¹

  摘要：

  DOI：

  10.1021/ja01645a002
• 作为产物：
  描述：

  7-Oxa-bicyclo-<2.2.1>-hept-5-en-2,3-exo,exo-dicarbonsaeure 在 ammonium hydroxide 作用下， 生成 exo-7-oxabicyclo[2.2.1]hept-4-ene-2,3-dicarboximide
  参考文献：
  名称：

  Zawadowski,T. et al., Roczniki Chemii, 1973, vol. 47, p. 189 - 191

  摘要：

  DOI：

文献信息

• Universal building blocks and support media for synthesis of oligonucleotides and their analogs
  申请人：——

  公开号：US20040152905A1

  公开（公告）日：2004-08-05

  Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

  提供用于合成寡聚化合物，特别是寡核苷酸和化学修饰的寡核苷酸类似物的化合物。此外，还提供了将支持介质功能化为第一单体亚基的方法，以及利用与支持介质结合的新化合物合成寡聚化合物的方法。
• [EN] HYDROPHILIC LINKERS AND THEIR USES FOR CONJUGATION OF DRUGS TO CELL BINDING MOLECULES<br/>[FR] LIEURS HYDROPHILES ET LEURS UTILISATIONS POUR LA CONJUGAISON DE MÉDICAMENTS À DES MOLÉCULES SE LIANT AUX CELLULES
  申请人：HANGZHOU DAC BIOTECH CO LTD

  公开号：WO2014080251A1

  公开（公告）日：2014-05-30

  Cell binding agent-drug conjugates comprising hydrophilic linkers, and methods of using such linkers and conjugates are provided.

  细胞结合剂-药物偶联物包括亲水性连接剂，并提供使用这种连接剂和偶联物的方法。
• Synthesis of New Aryl-substituted Tandospirone and Epiboxidine Analogues and Isoxazoline Derivatives
  作者：Irem Kulu、Gokce Goksu、Bilgesu Onur Sucu、Asli Kopruceli、Nuket Ocal、Dieter E. Kaufmann

  DOI：10.1080/00304948.2013.743423

  日期：2013.1

  Synthesis of New Aryl-substituted Tandospirone and Epiboxidine Analogues and Isoxazoline Derivatives Irem Kulu a , Gokce Goksu a , Bilgesu Onur Sucu a , Asli Kopruceli a , Nuket Ocal a & Dieter E. Kaufmann b a Yildiz Technical University, Faculty of Science and Arts, Department of Chemistry, Davutpasa Campus, 34220, Esenler, Istanbul, Turkey b Institute of Organic Chemistry, Clausthal University of

  新的芳基取代的坦度螺酮和埃博西丁类似物和异恶唑啉衍生物的合成 Irem Kulu a、Gokce Goksu a、Bilgesu Onur Sucu a、Asli Kopruceli a、Nuket Ocal a 和 Dieter E. Kaufmann ba Yildiz 技术大学，科学与艺术学院，化学学士，Davutpasa 校区，34220，Esenler，伊斯坦布尔，土耳其 b 克劳斯塔尔理工大学有机化学研究所，莱布尼茨街。6, D-38678, Clausthal-Zellerfeld, 德国
• Synthesis of a Bridging Ligand with a Non-denatured Protein Pendant: Toward Protein Encapsulation in a Coordination Cage
  作者：Daishi Fujita、Kosuke Suzuki、Sota Sato、Maho Yagi-Utsumi、Eiji Kurimoto、Yoshiki Yamaguchi、Koichi Kato、Makoto Fujita

  DOI：10.1246/cl.2012.313

  日期：2012.3.5

  Toward protein encapsulation by a synthetic host, we synthesized an ubiquitin-dangled ligand, a potential precursor of a nanoscale coordination cage. The key step is the addition of a C-terminal Cys76 SH group, which was introduced by Gly76Cys mutation, to a maleimide acceptor on the ligand. The C-terminal mutation and the SH addition to the ligand did not damage the ubiquitin moiety at all, neither structurally nor conformationally.

  我们合成了一种由合成宿主包裹蛋白质的途径，即一个悬挂着泛素的配体，它可能是一种纳米级配位笼的前体。关键步骤是将C末端的Cys76 SH基团（通过Gly76Cys突变引入）添加到配体上的马来酰亚胺受体。C末端突变和SH添加到配体中对泛素的结构或构象没有造成任何损害。
• ANTIMICROBIAL POLYMERS
  申请人：Tew Gregory

  公开号：US20100317870A1

  公开（公告）日：2010-12-16

  The invention generally relates to novel polymers (SMAMPs) and their syntheses and use. The polymers exhibit promising properties of AMPs. In particularly, for example, a ring-opening metathesis polymerization (ROMP) platform was developed that allows syntheses of SMAMPs that employ a minimum number of norbornene-based building blocks and/or enable easy and independent variation of hydrophobic and hydrophilic groups in the monomer units and/or along the polymeric backbone to finetune and select desirable properties of the polymers.

  这项发明通常涉及新型聚合物（SMAMPs）及其合成和使用。这些聚合物表现出类似于AMPs的有前途的性质。特别是，例如，开环甲硅烷聚合（ROMP）平台已经开发出来，允许合成利用最少数量的基于诺邦烯的构建块的SMAMPs，并/或使疏水性和亲水性基团在单体单元和/或沿着聚合物主链上容易且独立地变化，以微调和选择聚合物的理想性质。