5-(3,5-二甲氧基苯基)咪唑烷-2,4-二酮 | 116435-46-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 5-(3,5-二甲氧基苯基)咪唑烷-2,4-二酮
• 英文名称: 5-(3,5-Dimethoxyphenyl)imidazolidine-2,4-dione
• CAS: 116435-46-2
• 化学式: C₁₁H₁₂N₂O₄
• mdl: MFCD03931424
• 分子量: 236.227
• InChiKey: QFRGVTJEJUFFMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(3,5-二甲氧基苯基)咪唑烷-2,4-二酮 在 盐酸 、 Na borate buffer 、 三溴化硼 、 manganese(ll) chloride 、 sodium nitrite 作用下， 以 二氯甲烷 为溶剂， 反应 88.0h， 生成 (R)-3,5-DHPG
  参考文献：
  名称：

  Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins

  摘要：

  A series of 17 ring-mono and -disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl D-amino acids. No significant L-hydantoinase activity was found to produce the corresponding L-enantiomers. (C) 1997, Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(96)00488-0
• 作为产物：
  描述：

  氰化钾 、 碳酸氢铵 、 3,5-二甲氧基苯甲醛 在 水 作用下， 以 乙醇 为溶剂， 生成 5-(3,5-二甲氧基苯基)咪唑烷-2,4-二酮
  参考文献：
  名称：

  Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins

  摘要：

  A series of 17 ring-mono and -disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl D-amino acids. No significant L-hydantoinase activity was found to produce the corresponding L-enantiomers. (C) 1997, Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(96)00488-0

文献信息

• US4094741A
  申请人：——

  公开号：US4094741A

  公开（公告）日：1978-06-13
• Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins
  作者：Maria J. Garcia、Robert Azerad

  DOI：10.1016/s0957-4166(96)00488-0

  日期：1997.1

  A series of 17 ring-mono and -disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl D-amino acids. No significant L-hydantoinase activity was found to produce the corresponding L-enantiomers. (C) 1997, Elsevier Science Ltd. All rights reserved.