10-methyl-5,5-dioxo-5λ⁶-phenothiazine-3,7-diyldiamine | 93003-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 10-methyl-5,5-dioxo-5λ⁶-phenothiazine-3,7-diyldiamine
• 英文别名: 10-Methyl-5,5-dioxo-5λ⁶-phenothiazin-3,7-diyldiamin；10-Methyl-5,5-dioxophenothiazine-3,7-diamine
• CAS: 93003-44-2
• 化学式: C₁₃H₁₃N₃O₂S
• 分子量: 275.331
• InChiKey: FDNSGQZNKVQWGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  97.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  10-methyl-5,5-dioxo-5λ⁶-phenothiazine-3,7-diyldiamine 生成 3,7-dichloro-10-methyl-10H-phenothiazine 5,5-dioxide
  参考文献：
  名称：

  Antonow, Doklady Bolgarskoi Akademii Nauk, 1957, vol. 10, p. 21,23

  摘要：

  DOI：
• 作为产物：
  描述：

  10-methyl-3,7-dinitrophenothiazine 5-oxide 在 platinum(IV) oxide 氢气 、 双氧水 、 溶剂黄146 作用下， 生成 10-methyl-5,5-dioxo-5λ⁶-phenothiazine-3,7-diyldiamine
  参考文献：
  名称：

  Selective Inhibitors of Monoamine Oxidase. 2. Arylamide SAR

  摘要：

  Monoamine oxidase (MAO) exists in two forms distinguishable by substrate specificity. Inhibition of MAO A is believed to be responsible for the antidepressant activity of MAO inhibitors. A group of N-arylacetamides are highly specific inhibitors of MAO A, some with IC50 values in the 10-100 nM range. The requirements for high activity and specificity include a nearly linear tricyclic aromatic portion but a larger and a smaller central ring component. The amide group, which is best acetamido, is optimally placed para to the smaller central group. The size and shape of the aromatic moiety appear to be the major influence on activity and specificity for MAO A.

  DOI：

  10.1021/jm00039a021

文献信息

• Epoxy resin compositions with improved storage stability
  申请人：HERCULES INCORPORATED

  公开号：EP0604909A2

  公开（公告）日：1994-07-06

  Epoxy resin compositions having improved storage stability before curing and improved thermal and mechanical performance after curing comprise a mixture of a polyepoxide and a curing agent that is reactive with the polyepoxide. The epoxy resin composition is characterized by a glass transition temperature of less than 20°C, measured under standard conditions, after subjecting the epoxy resin composition to a specified thermal cycle. For attaining this, the curing agent should possess a melting point and a heat of fusion lying in area A of fig.1. The preferred curing agents are aromatic diamines, for example, 3,7-diaminodibenzothiophene-5,5-dioxide; 3,7-diaminophenothiazine sulfone, 3,7-diamino-N-methylphenothiazine sulfone; 2,7-diamino-9-fluorenone and 2,4,6,8-tetramethyl-3,7-diaminothioxanthene sulfone. Also claimed are prepregs and composites made therefrom containing the epoxy compositions in combination with reinforcing agents.

  环氧树脂组合物在固化前具有更好的储存稳定性，在固化后具有更好的热性能和机械性能，该组合物包括一种聚环氧化物和一种与聚环氧化物反应的固化剂的混合物。环氧树脂组合物的特点是，在标准条件下，将环氧树脂组合物置于特定的热循环中后，玻璃化转变温度小于 20°C。为此，固化剂的熔点和熔融热应在图 1 的 A 区域内。首选的固化剂是芳香族二胺，例如：3,7-二氨基二苯并噻吩-5,5-二氧化物；3,7-二氨基吩噻嗪砜；3,7-二氨基-N-甲基吩噻嗪砜；2,7-二氨基-9-芴酮和 2,4,6,8-四甲基-3,7-二氨基噻吨砜。此外，还要求获得含有环氧树脂组合物和增强剂的预浸料及其复合材料。
• Harfenist Morton, Joyner Charles T., Mize Patrick D., White Helen L., J. Med. Chem, 37 (1994) N 13, S 2085-2089
  作者：Harfenist Morton, Joyner Charles T., Mize Patrick D., White Helen L.

  DOI：——

  日期：——
• Antonow, Izvestiya na Khimicheskiya Institut, Bulgarska Akademiya na Naukite, 1957, vol. 5, p. 51,65
  作者：Antonow

  DOI：——

  日期：——
• Antonow, Izvestiya na Khimicheskiya Institut, Bulgarska Akademiya na Naukite, 1953, vol. 2, p. 97,110
  作者：Antonow

  DOI：——

  日期：——
• Method for removing water vapor from water vapor-containing gas
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0263212B1

  公开（公告）日：1990-12-27