1-bromo-8-(naphthalene-1-yl)-pyrene | 870774-31-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 1-bromo-8-(naphthalene-1-yl)-pyrene
• 英文别名: 1-Bromo-8-(naphthalen-1-yl)pyrene；1-bromo-8-naphthalen-1-ylpyrene
• CAS: 870774-31-5
• 化学式: C₂₆H₁₅Br
• 分子量: 407.309
• InChiKey: WBIHNLJSVYFVGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• [EN] CYCLIC INHIBITORS OF 11ß-HYDROXYSTERIOD DEHYDROGENASE 1<br/>[FR] INHIBITEURS CYCLIQUES DE LA 11?-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE 1
  申请人：VITAE PHARMACEUTICALS INC

  公开号：WO2009017664A1

  公开（公告）日：2009-02-05

  This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih); (Ii); (Ij), (Ik), (II) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

  本发明涉及式(I)、(Ia)、(Ib)、(Ic)、(Id)、(Ie)、(If)、(Ig)、(Ih)；(Ii)；(Ij)，(Ik)，(II)的新颖化合物，其药用可接受的盐以及药物组合物，这些化合物对于治疗与调节或抑制哺乳动物中的11β-HSD1相关的疾病是有用的。本发明进一步涉及新颖化合物的药物组合物及其在减少或控制细胞中皮质醇的产生或抑制细胞中将可的松转化为皮质醇的方法。
• Asymmetric pyrene derivative and organic electroluminescence device employing the same
  申请人：Kubota Mineyuki

  公开号：US20060154107A1

  公开（公告）日：2006-07-13

  Asymmetric pyrene derivatives having specific structure. An organic EL device comprising at least one organic thin film layer including a light emitting layer sandwiched between a pair of electrode consisting of an anode and a cathode, wherein the organic thin film layer comprises at least one kind selected from the aforementioned asymmetric pyrene derivatives singly or as a component of mixture thereof. An organic EL device exhibiting a great efficiency of light emission and having a long lifetime, and also asymmetric pyrene derivatives for realizing the organic EL device are provided.

  具有特定结构的不对称芘衍生物。一种有机EL器件，包括至少一个有机薄膜层，其中包括一个发光层，夹在由阳极和阴极组成的一对电极之间，其中有机薄膜层包括从上述不对称芘衍生物中选择的至少一种，单独或作为混合物的组分。提供了一种具有高效发光和长寿命的有机EL器件，以及实现该有机EL器件的不对称芘衍生物。
• ASYMMETRIC PYRENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE EMPLOYING THE SAME
  申请人：KUBOTA Mineyuki

  公开号：US20100308718A1

  公开（公告）日：2010-12-09

  Asymmetric pyrene derivatives having specific structure. An organic EL device comprising at least one organic thin film layer including a light emitting layer sandwiched between a pair of electrode consisting of an anode and a cathode, wherein the organic thin film layer comprises at least one kind selected from the aforementioned asymmetric pyrene derivatives singly or as a component of mixture thereof. An organic EL device exhibiting a great efficiency of light emission and having a long lifetime, and also asymmetric pyrene derivatives for realizing the organic EL device are provided.

  具有特定结构的非对称芘衍生物。一种有机EL器件，包括至少一个有机薄膜层，其中包括夹在由阳极和阴极组成的一对电极之间的发光层，其中有机薄膜层包括上述非对称芘衍生物之一或其混合物组分。提供一种具有出色的发光效率和长寿命的有机EL器件，以及实现有机EL器件的非对称芘衍生物。
• ASYMMETRIC PYRENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME
  申请人：IDEMITSU KOSAN CO., LTD.

  公开号：EP1749809A1

  公开（公告）日：2007-02-07

  Asymmetric pyrene derivatives having specific structure. An organic EL device comprising at least one organic thin film layer including a light emitting layer sandwiched between a pair of electrode consisting of an anode and a cathode, wherein the organic thin film layer comprises at least one kind selected from the aforementioned asymmetric pyrene derivatives singly or as a component of mixture thereof.. An organic EL device exhibiting a great efficiency of light emission and having a long lifetime, and also asymmetric pyrene derivatives for realizing the organic EL device are provided.

  具有特定结构的不对称芘衍生物。一种有机电致发光器件，包括至少一个有机薄膜层，该薄膜层包括夹在由阳极和阴极组成的一对电极之间的发光层，其中有机薄膜层包括至少一种选自上述不对称芘衍生物的单个或作为其混合物成分的衍生物。本发明提供了一种发光效率高、寿命长的有机电致发光器件，以及用于实现该有机电致发光器件的不对称芘衍生物。
• CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1
  申请人：Vitae Pharmaceuticals, Inc.

  公开号：EP2183228A1

  公开（公告）日：2010-05-12