Hexadecanoic acid 2-[bis-(2-hexadecanoyloxy-ethyl)-amino]-ethyl ester | 88931-91-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Hexadecanoic acid 2-[bis-(2-hexadecanoyloxy-ethyl)-amino]-ethyl ester
• 英文别名: 2-[Bis(2-hexadecanoyloxyethyl)amino]ethyl hexadecanoate；2-[bis(2-hexadecanoyloxyethyl)amino]ethyl hexadecanoate
• CAS: 88931-91-3
• 化学式: C₅₄H₁₀₅NO₆
• 分子量: 864.431
• InChiKey: RCFRANKMKBHWIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  21.9
• 重原子数：
  61
• 可旋转键数：
  54
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  溴甲烷 、 Hexadecanoic acid 2-[bis-(2-hexadecanoyloxy-ethyl)-amino]-ethyl ester 以 苯 为溶剂， 反应 168.0h， 生成 O,O',O''-trihexadecanoyl-N-methyltriethanolamine bromide
  参考文献：
  名称：

  三链铵两亲物的双层膜

  摘要：

  制剂 10 包括两亲物 d'铵 quaternaire qui possedent 3 «queues» de longues chainesalkaliques (C 12 ou C 16 ) 和 qui donnent dessuspends auqueuses sous l'effet d'ultrasedent。Les etudes de microscopie electronique et de spread de lumiere indiquent la形成d'agregats de couches bimoleculaires (dans tous les cas sauf un)

  DOI：

  10.1021/ja00319a014
• 作为产物：
  描述：

  三乙醇胺 、 棕榈酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 20.0h， 生成 Hexadecanoic acid 2-[bis-(2-hexadecanoyloxy-ethyl)-amino]-ethyl ester
  参考文献：
  名称：

  三链铵两亲物的双层膜

  摘要：

  制剂 10 包括两亲物 d'铵 quaternaire qui possedent 3 «queues» de longues chainesalkaliques (C 12 ou C 16 ) 和 qui donnent dessuspends auqueuses sous l'effet d'ultrasedent。Les etudes de microscopie electronique et de spread de lumiere indiquent la形成d'agregats de couches bimoleculaires (dans tous les cas sauf un)

  DOI：

  10.1021/ja00319a014

文献信息

• [EN] POLYAMINE-FATTY ACID DERIVED LIPIDOIDS AND USES THEREOF<br/>[FR] LIPIDOÏDES DÉRIVÉS DE POLYAMINE-ACIDE GRAS ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2016004202A1

  公开（公告）日：2016-01-07

  The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of Formula (I) or (II)) and methods of preparing the lipidoids. A described lipidoid includes R-C(=0)-0- moieties (where R is a lipid moiety), which may be hydrolyzed into non-toxic fatty acids. Also provided are compositions including a described lipidoid and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that involve the lipidoids or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, and metabolic disorders.

  本公开提供了聚胺脂肪酸衍生的脂质体（例如，化合物的化学式（I）或（II））以及制备脂质体的方法。所述脂质体包括R-C(=0)-0-基团（其中R是脂质基团），可以水解为无毒脂肪酸。还提供了包括所述脂质体和药剂（例如，多核苷酸、小分子、肽或蛋白质）的组合物。本公开还提供了涉及脂质体或组合物用于将药剂传递给受体、组织或细胞和/或用于治疗和/或预防一系列疾病的方法、试剂盒和用途，例如遗传疾病、增殖性疾病、血液疾病、神经系统疾病、免疫系统疾病、胃肠道疾病、呼吸系统疾病、疼痛症状、精神障碍和代谢性疾病。
• Production of Palm-Based Esteramine Through Heterogeneous Catalysis
  作者：Haliza Abdul Aziz、Mohamed Kheireddine Aroua、Rozita Yusoff、Noor Azeerah Abas、Zainab Idris、Hazimah Abu Hassan

  DOI：10.1007/s11743-015-1736-0

  日期：2016.1

  This study involved maximizing the conversion of palm‐based methyl palmitate to esteramine, an intermediate for esterquats via transesterification with triethanolamine, aided by Ca–Al as a heterogeneous catalyst in a 500‐ml reaction unit. The effect of process parameters on the conversion was investigated. The optimum process parameters, consisting of a mole ratio of 1.8:1 (methyl palmitate:triethanolamine)

  这项研究涉及最大程度地将棕榈基棕榈酸甲酯转化为酯胺（酯胺是通过与三乙醇胺进行酯交换反应而形成的酯季铵盐的中间体），并在500 ml反应装置中借助Ca-Al作为非均相催化剂。研究了工艺参数对转化率的影响。最佳的工艺参数由1.8：1（棕榈酸甲酯：三乙醇胺）的摩尔比，170°C，10 mbar，0.5％的催化剂和2小时的持续时间组成，转化率超过90％。与传统的使用甲醇钠的方法相比，使用Ca-Al进行的酯交换反应对环境更加友好，简化了下游分离过程，并在随后的三个循环中成功测试了催化剂的可重复使用性。
• POLYAMINE-FATTY ACID DERIVED LIPIDOIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160002178A1

  公开（公告）日：2016-01-07

  The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of Formula (I) or (II)) and methods of preparing the lipidoids. A described lipidoid includes R—C(═O)—O— moieties (where R is a lipid moiety), which may be hydrolyzed into non-toxic fatty acids. Also provided are compositions including a described lipidoid and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that involve the lipidoids or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, and metabolic disorders.
• Method for Pore Sealing of Porous Materials Using Polyimide Langmuir-Blodgett Film
  申请人：IMEC

  公开号：US20170021604A1

  公开（公告）日：2017-01-26

  Method for pore sealing a porous substrate, comprising: forming a continuous monolayer of a polyimide precursor on a liquid surface, transferring said polyimide precursor monolayer onto the porous substrate with the Langmuir-Blodgett technique, and imidization of the transferred polyimide precursor monolayers, thereby forming a polyimide sealing layer on the porous substrate. Porous substrate having at least one surface on which a sealing layer is provided to seal pores of the substrate, wherein the sealing layer is a polyimide having a thickness of a few monolayers and wherein there is no penetration of the polyimide into the pores.
• US9840479B2
  申请人：——

  公开号：US9840479B2

  公开（公告）日：2017-12-12