[EN] METHOD FOR SEPARATING CHROMATOGRAPHICALLY INDISTINGUISHABLE 2-AZIDO-1-NITRATES<br/>[FR] PROCÉDÉ DE SÉPARATION DE 2-AZIDO-1-NITRATES INDISTINGUABLES PAR CHROMATOGRAPHIE
申请人:SINUTRON KG
公开号:WO2019002594A1
公开(公告)日:2019-01-03
The present invention discloses a method for separating chromatographically indistinguishable 1,2-diaxial from 1,2- diequatorial disaccharide 2-azido-1-nitrates, wherein the disaccharide is a 1→4 disaccharide, comprising the steps of -providing a mixture of chromatographically indistinguishable,2-diaxial from 1,2-diequatorial 2-azido-1-nitrates, -treating the mixture with a nucleophile, selected from the group of tetraalkylammonium salts, preferably tetraalkylammonium nitrate, and -obtaining the 1-axial-2-equatorial 2-azido-1-nitratefrom the treated mixture.
本发明公开了一种从色谱上无法区分的1,2-二轴向和1,2-二赤道二糖2-叠氮基-1-硝酸酯中分离1,2-二轴向的方法,其中二糖是1→4二糖,包括以下步骤:-提供一个混合物,其中色谱上无法区分的1,2-二轴向和1,2-二赤道2-叠氮基-1-硝酸酯,-用来自四烷基铵盐组的亲核试剂处理混合物,优选为四烷基铵硝酸盐,-从处理后的混合物中获取1-轴向-2-赤道2-叠氮基-1-硝酸酯。