The present invention discloses a method for separating chromatographically indistinguishable 1,2-diaxial from 1,2-diequatorial disaccharide azidonitrates, wherein the disaccharide is a 1→4 disaccharide, comprising the steps of
- providing a mixture of chromatographically indistinguishable 1,2-diaxial from 1,2-diequatorial azidonitrates,
- treating the mixture with a nucleophile, selected from the group of tetraalkylammonium salts, preferably tetraalkylammonium nitrate, and
- obtaining the 1-axial-2-equatorial derivative from the treated mixture.
本发明公开了一种分离色谱法上无法区分的 1,2-二轴与 1,2-二端二糖
叠氮硝酸酯的方法,其中二糖为 1→4 二糖,该方法包括以下步骤
- 提供色谱上无法区分的 1,2-二轴与 1,2-二端偶氮
硝酸酯的混合物、
- 用亲核剂(选自四烷基
铵盐,最好是
硝酸四烷基
铵)处理混合物,以及
- 从处理过的混合物中获得 1 轴-2-赤道衍
生物。