N-(benzyloxycarbonyl)-6-aminohexyl methanesulfonate | 75937-26-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(benzyloxycarbonyl)-6-aminohexyl methanesulfonate
• 英文别名: 6-(Phenylmethoxycarbonylamino)hexyl methanesulfonate
• CAS: 75937-26-7
• 化学式: C₁₅H₂₃NO₅S
• 分子量: 329.417
• InChiKey: CFJOIFSGIRKXQT-UHFFFAOYSA-N

物化性质

• 沸点：
  526.9±43.0 °C(Predicted)
• 密度：
  1.187±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(benzyloxycarbonyl)-6-aminohexyl methanesulfonate 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以46%的产率得到1-(Benzyloxycarbonyl)hexahydro-1H-azepine
  参考文献：
  名称：

  Nicolaou, K. C.; Koide, Kazunori; Bunnage, Mark E., Chemistry - A European Journal, 1995, vol. 1, # 7, p. 454 - 466

  摘要：

  DOI：
• 作为产物：
  描述：

  6-氨基-1-己醇 在 吡啶 、 碳酸氢钠 作用下， 以 水 为溶剂， 反应 2.5h， 生成 N-(benzyloxycarbonyl)-6-aminohexyl methanesulfonate
  参考文献：
  名称：

  DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of (1,2-diaminoethane)dichloroplatinum(II)

  摘要：

  A series of acridine-2- and -4-carboxamide-linked analogues of PtenCl2 has been prepared and evaluated for biological activity against several tumor cell lines in vitro and in vivo. The platinum complexes were generally more cytotoxic than the corresponding ligands against wild-type P388 leukemia cells in vitro, with acridine-4-carboxamide complexes being the more effective. In contrast to cisplatin and PtenCl2, the complexes were equally active in vitro against both wild-type and cisplatin-resistant P388 lines. The 4-carboxamide complexes showed high levels of in vivo activity (ILS >100%) against wild-type P388 using a single-dose protocol, and one compound was also significantly active in vivo in a cisplatin-resistant line, against which cisplatin and PtenCl2 are inactive.

  DOI：

  10.1021/jm00094a008

文献信息

• Quadruple hydrogen bonded cytosine modules: N-1 functionalised arrays
  作者：Valerie G. H. Lafitte、Abil E. Aliev、Elisabetta Greco、Kason Bala、Peter Golding、Helen C. Hailes

  DOI：10.1039/c1nj20162j

  日期：——

  A ureidocytosine (UCyt) module with a pendant amine linker at N-1 has been prepared for applications in supramolecular quadruple hydrogen bonded array synthesis. Subsequent conjugation to four amine terminated telechelic polymers led to the formation of oligomeric DDAA arrays, as determined by NMR diffusion measurements, establishing that N-1 as well as N-9 ureidocytosine polymeric arrays can readily be accessed.

  已经制备了一种带有N-1位置的侧链胺链接的尿嘧啶细胞苷（UCyt）模块，以用于超分子四重氢键阵列合成。随后与四种氨基终止的聚合物进行偶联，导致形成寡聚DDAA阵列，通过NMR扩散测量确定，证明N-1和N-9尿嘧啶细胞苷聚合物阵列均可以方便地获取。
• Clarithromycin–adenine and related conjugates
  作者：Jorge Esteban、Anna M. Costa、M. Carmen Cruzado、Montserrat Faja、Pilar García、Jaume Vilarrasa

  DOI：10.1016/j.tetlet.2006.01.079

  日期：2006.3

  Macrolide-nucleoside and macrolide-nucleobase conjugates (chimeras) have been synthesised by linking erythromycin A oxime derivatives and clarithromycin C11,C12-oxazolidinone derivatives with 3'-amino-3'-deoxythymidine or adenine through different spacers; clarithromycin-adenine conjugate 16a is the most active species against Micrococcus luteus. (c) 2006 Elsevier Ltd. All rights reserved.
• US4273866A
  申请人：——

  公开号：US4273866A

  公开（公告）日：1981-06-16
• US4550163A
  申请人：——

  公开号：US4550163A

  公开（公告）日：1985-10-29
• Nicolaou, K. C.; Koide, Kazunori; Bunnage, Mark E., Chemistry - A European Journal, 1995, vol. 1, # 7, p. 454 - 466
  作者：Nicolaou, K. C.、Koide, Kazunori、Bunnage, Mark E.

  DOI：——

  日期：——