2H-benzo[b][1]benzazepin-2-ylium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2H-benzo[b][1]benzazepin-2-ylium
• 化学式: C₁₄H₁₀N
• 分子量: 192.24
• InChiKey: ATSPRJZAORVGOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  亚氨基芪 以 苯 为溶剂， 生成 2H-benzo[b][1]benzazepin-2-ylium
  参考文献：
  名称：

  Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines

  摘要：

  Type 1 phototherapeutic agents based on diarylamines were assessed for free radical generation and evaluated in vitro for cell death efficacy in the U937 leukemia cancer cell line. All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance (ESR) spectroscopy. Among the diarylamines, the most potent compounds were acridan (4) and 9-phenylacridan (5), with IC50 values of 0.68 mu M and 0.17 mu M, respectively.

  DOI：

  10.1021/ml200266v

文献信息

• Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines
  作者：Raghavan Rajagopalan、Tien-Sung Lin、Amolkumar S. Karwa、Amruta R. Poreddy、Bethel Asmelash、Richard B. Dorshow

  DOI：10.1021/ml200266v

  日期：2012.4.12

  Type 1 phototherapeutic agents based on diarylamines were assessed for free radical generation and evaluated in vitro for cell death efficacy in the U937 leukemia cancer cell line. All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance (ESR) spectroscopy. Among the diarylamines, the most potent compounds were acridan (4) and 9-phenylacridan (5), with IC50 values of 0.68 mu M and 0.17 mu M, respectively.