5-Phenyl-pentadien-(2.4)-saeure-(1)-anilid | 62764-16-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Phenyl-pentadien-(2.4)-saeure-(1)-anilid
• 英文别名: 5-phenyl-penta-2,4-dienoic acid anilide；5-Phenyl-penta-2,4-diensaeure-anilid；N,5-diphenylpenta-2,4-dienamide
• CAS: 62764-16-3
• 化学式: C₁₇H₁₅NO
• 分子量: 249.312
• InChiKey: QKPXQVORHNBNOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  肉桂醛 、 N-乙酰苯胺 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 3.5h， 生成 5-Phenyl-pentadien-(2.4)-saeure-(1)-anilid
  参考文献：
  名称：

  Hydrogen Bond-Assisted 6π-Azaelectrocyclization of Penta-2,4-dienamides: Synthesis of Dihydropyridin-2(3H)-ones

  摘要：

  A facile and efficient synthesis of substituted dihydropyridin-2(3H)-ones is developed from penta-2,4-dienamides, in which an intramolecular C-N bond was formed through thermal 6 pi-azaelectrocyclization. The intra-molecular hydrogen bonding-assisted cyclization reaction opens access to a variety of dihydropyridin-2(3H)-ones.

  DOI：

  10.1021/jo4001959

文献信息

• Hydrogen Bond-Assisted 6π-Azaelectrocyclization of Penta-2,4-dienamides: Synthesis of Dihydropyridin-2(3<i>H</i>)-ones
  作者：Xu Liu、Ning Zhang、Jiming Yang、Yongjiu Liang、Rui Zhang、Dewen Dong

  DOI：10.1021/jo4001959

  日期：2013.4.5

  A facile and efficient synthesis of substituted dihydropyridin-2(3H)-ones is developed from penta-2,4-dienamides, in which an intramolecular C-N bond was formed through thermal 6 pi-azaelectrocyclization. The intra-molecular hydrogen bonding-assisted cyclization reaction opens access to a variety of dihydropyridin-2(3H)-ones.