2,6-diethylpyridine-3-carboxamide | 122775-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-diethylpyridine-3-carboxamide
• CAS: 122775-96-6
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: KTVYFAIJIHOHNL-UHFFFAOYSA-N

物化性质

• 熔点：
  122 °C(Solv: benzene (71-43-2))
• 沸点：
  275.3±40.0 °C(Predicted)
• 密度：
  1.067±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-diethylpyridine-3-carboxamide 、 氯甲酸苯酯 、 phenylmagnesium bromide 、 、 四氢呋喃 在 碘化亚铜 氯化铵 、 乙醚 、 aquous solution 、 Ammonia ammonium chloride 、 水 、 盐酸 作用下， 以 乙醚 为溶剂， 反应 16.25h， 以to yield 3-[(diethylamino)carbonyl]-1(4H)-pyridinecarboxylic acid, phenyl ester as a yellow oil的产率得到3-[(diethylamino)carbonyl]-1(4H)-pyridinecarboxylic acid, phenyl ester
  参考文献：
  名称：

  Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide

  摘要：

  本文披露了具有肌动蛋白结合活性的某些取代的1,2,3,6-四氢和1,2,5,6-四氢吡啶-3-羧酸、酯和酰胺，适用于治疗老年认知衰退症状。此外还披露了制药组合物和制药治疗方法。

  公开号：

  US04745123A1
• 作为产物：
  描述：

  烟酰胺 、 丙酸 生成 2,6-diethylpyridine-3-carboxamide
  参考文献：
  名称：

  TADA, MASARU;YOKOI, YURIE, J. HETEROCYCL. CHEM., 26,(1989) N, C. 45-48

  摘要：

  DOI：

文献信息

• NOVEL POLYMER-BASED HYDROTROPES FOR HYDROPHOBIC DRUG DELIVERY
  申请人：Nitto Denko Corporation

  公开号：US20150283253A1

  公开（公告）日：2015-10-08

  Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.

  聚合物共轭物的特征在于聚合物的主链是阴离子聚合物，疏水基团被共价连接到聚合物主链上，用于制备药物封装的聚合物水热溶剂和组合物。这种材料在将药物输送到细胞中的方法以及用于治疗和缓解癌症等疾病和疾病是有用的。
• [EN] DRUG FORMULATION BASED ON PARTICULATES COMPRISING POLYSACCHARIDE-VITAMIN CONJUGATE<br/>[FR] FORMULATION MÉDICAMENTEUSE À BASE DE PARTICULES COMPRENANT UN CONJUGUÉ POLYSACCHARIDE-VITAMINE
  申请人：ZY THERAPEUTICS INC

  公开号：WO2017053920A1

  公开（公告）日：2017-03-30

  The present disclosure provides formulations for pharmacologically active reagents, including formulations based on particulates formed from a biodegradable polymer (e.g., a polysaccharide such as dextran) linked to a vitamin or related agent (e.g., folic acid). Hydrophobic pharmaceutically active agents (such as anti-cancer drugs, e.g., paclitaxel) are encapsulated into the polysaccharide-vitamin conjugate for the administration of paclitaxel. The active agent is in a core portion of the particulate, instead of on the surface of the particulate. Processes for making and using the particulates and compositions comprising the same are also disclosed. In particular, methods of cancer diagnosis and treatment are provided.

  本公开提供了用于药理活性试剂的配方，包括基于由可生物降解聚合物（例如，多糖类如葡聚糖）形成的颗粒的配方，该聚合物与维生素或相关剂（例如，叶酸）相连。疏水性药用活性剂（例如抗癌药物，例如紫杉醇）被封装到多糖-维生素共轭物中，以用于紫杉醇的给药。活性剂位于颗粒的核心部分，而不是在颗粒表面。还公开了制备和使用这些颗粒以及包含它们的组合物的过程。特别提供了癌症诊断和治疗的方法。
• Organic photochromic compound
  申请人：SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0394846A2

  公开（公告）日：1990-10-31

  An organic photochromic compound with improved long term preservability, thermal stability, the repetition character of the record and the like and useful as recording-memory materials or photosensitizers, comprising the compound selected from pyrido[3,4-g]isoquinoline, pyrido[2,3-g]quinoline, pyrido[3,2-g]quinoline and pyrido[3,2-g]quinoline derivatives.

  一种有机光致变色化合物，具有更好的长期保存性、热稳定性、记录重复性等，可用作记录记忆材料或光敏剂，包括选自吡啶并[3,4-g]异喹啉、吡啶并[2,3-g]喹啉、吡啶并[3,2-g]喹啉和吡啶并[3,2-g]喹啉衍生物的化合物。
• Polymer-based hydrotropes for hydrophobic drug delivery
  申请人：Nitto Denko Corporation

  公开号：US10080737B2

  公开（公告）日：2018-09-25

  Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.

  聚合物共轭物的特点是聚合物的骨架是阴离子聚合物，疏水分子共价连接到聚合物骨架上，这种共轭物可用于制备药物包封聚合物水托品和组合物。这种材料适用于将药物输送到细胞中的方法，也适用于治疗和缓解癌症等疾病。
• Polyaniline membranes, uses, and methods thereto
  申请人：The Regents of the University of California

  公开号：US10265662B2

  公开（公告）日：2019-04-23

  Disclosed herein are methods of increasing the hydrophilicity of a membrane. Membranes comprising polyaniline or co-polymer thereof and one or more gel inhibiting agents are treated with one or more hydrophilicity restoration agents, thereby increasing the hydrophilicity of a membrane. Also disclosed are membranes produced by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文公开了增加膜亲水性的方法。用一种或多种亲水性恢复剂处理包含聚苯胺或其共聚物和一种或多种凝胶抑制剂的膜，从而增加膜的亲水性。还公开了用公开方法生产的膜。本摘要旨在作为特定技术领域的扫描工具，用于搜索目的，并非对本发明的限制。