palmyrrolinone | 1293988-33-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: palmyrrolinone
• 英文别名: (2S)-1-[(2E,4E)-6-hydroxy-3-methoxyhexa-2,4-dienoyl]-2-methyl-2H-pyrrol-5-one
• CAS: 1293988-33-6
• 化学式: C₁₂H₁₅NO₄
• 分子量: 237.255
• InChiKey: VHHVNQCXHWHJGF-VVQVOPMGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  palmyrrolinone 在 臭氧 、 甲酸 、 双氧水 、 盐酸 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 18.83h， 生成 L-丙氨酸
  参考文献：
  名称：

  Molluscicidal Metabolites from an Assemblage of Palmyra Atoll Cyanobacteria

  摘要：

  Molluscicides can play an important role in the control of schistosomiasis because snails of the genus Biomphalaria act as intermediate hosts for the parasite. Schistosomiasis is one of 13 neglected tropical diseases with high morbidity and mortality that collectively affect one billion of the world's poorest population, mainly in developing countries. Thiopalmyrone (1) and palmyrrolinone (2), metabolites isolated from extracts of a Palmyra Atoll environmental assemblage of two cyanobacteria, cf. Oscillatoria and Hormoscilla spp., represent new and potent molluscicidal chemotypes against Biomphalaria glabrata (LC50 = 8.3 and 6.0 mu M, respectively). A slight enhancement in molluscicidal effect (LC50 = 5.0 mu M) was observed when these two natural products were utilized as an equimolar binary mixture.

  DOI：

  10.1021/np200106b

文献信息

• Molluscicidal Metabolites from an Assemblage of Palmyra Atoll Cyanobacteria
  作者：Alban R. Pereira、Lena Etzbach、Niclas Engene、Rolf Müller、William H. Gerwick

  DOI：10.1021/np200106b

  日期：2011.5.27

  Molluscicides can play an important role in the control of schistosomiasis because snails of the genus Biomphalaria act as intermediate hosts for the parasite. Schistosomiasis is one of 13 neglected tropical diseases with high morbidity and mortality that collectively affect one billion of the world's poorest population, mainly in developing countries. Thiopalmyrone (1) and palmyrrolinone (2), metabolites isolated from extracts of a Palmyra Atoll environmental assemblage of two cyanobacteria, cf. Oscillatoria and Hormoscilla spp., represent new and potent molluscicidal chemotypes against Biomphalaria glabrata (LC50 = 8.3 and 6.0 mu M, respectively). A slight enhancement in molluscicidal effect (LC50 = 5.0 mu M) was observed when these two natural products were utilized as an equimolar binary mixture.