1-benzyl-2,3-dimethoxybenzene | 84056-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-2,3-dimethoxybenzene
• CAS: 84056-07-5
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: AWTRDWCJILMITI-UHFFFAOYSA-N

物化性质

• 沸点：
  121 °C(Press: 0.25 Torr)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzyl-2,3-dimethoxybenzene 在 sodium hypophosphite 、 氢碘酸 作用下， 生成 DL-β-<3,4-Dihydroxy-2-benzyl-phenyl>-α-alanin
  参考文献：
  名称：

  2-苄基和2-苯基-3,4-二羟基苯丙氨酸。

  摘要：

  DOI：

  10.1021/jm00341a040
• 作为产物：
  描述：

  (2,3-dimethoxyphenyl)(phenyl)methanol 生成 1-benzyl-2,3-dimethoxybenzene
  参考文献：
  名称：

  2-苄基和2-苯基-3,4-二羟基苯丙氨酸。

  摘要：

  DOI：

  10.1021/jm00341a040

文献信息

• Diarylmethanes through an Unprecedented Palladium-Catalyzed C−C Cross-Coupling of 1-(Aryl)methoxy-1 <i>H</i>-Benzotriazoles with Arylboronic Acids
  作者：Manish K. Singh、Mahesh K. Lakshman

  DOI：10.1002/cctc.201500818

  日期：2015.12

  1‐(Aryl)methoxy‐1H‐benzotriazoles (ArCH2OBt) are bench‐stable reagents that are prepared readily from 1H‐benzotriazol‐1‐yl‐4‐methylbenzenesulfonate and benzylic alcohols. These compounds, which contain a N−O−C bond, undergo cross‐coupling with arylboronic acids by C−O bond scission with catalysts that comprise Pd(OAc)2 and biarylphosphine ligands. Such reactivity of ArCH2OBt derivatives, which lead

  1-（芳基）甲氧基-1 H-苯并三唑（ArCH 2 OBt）是可从1 H-苯并三唑-1-基-4-甲基苯磺酸盐和苄基醇中轻松制备的稳定试剂。这些包含一个N-OC键的化合物，通过包含Pd（OAc）2和联芳基膦配体的催化剂的C-O键断裂，与芳基硼酸发生交叉偶联。先前没有描述过导致二芳基甲烷的ArCH 2 OBt衍生物的这种反应性，并构成了苄醇的新活化。关于支持催化活性的各种配体-金属配合物，似乎那些具有较小“埋入体积百分比”（％V bur）的配合物。）提供更好的结果。在最初的优化研究中以及与困难的偶联伙伴的进一步反应中已经评估了该因素。在这种类型的反应中，联芳基部分的配体电子似乎起着较小的作用。双配位的双[（2-二苯基膦基）苯基]醚似乎适合提高低产率反应的收率。
• NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF
  申请人：CHOI Kyung Il

  公开号：US20090325979A1

  公开（公告）日：2009-12-31

  Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

  揭示了作为钙通道调节剂有用的新型咪唑基烷基羰基衍生物，以及其制备方法。还揭示了一种通过给予上述化合物进行治疗的方法，该方法基于它们对钙通道的抑制活性。
• Direct alkylation of aromatics using alcohols in the presence of NaHSO4/SiO2
  作者：Yuta Sato、Tadashi Aoyama、Toshio Takido、Mitsuo Kodomari

  DOI：10.1016/j.tet.2012.06.063

  日期：2012.9

  Simple and efficient procedure for alkylation of aromatics from alcohols in the presence of NaHSO4/SiO2 was developed. Various triaryl methanes were obtained in good yields in short reaction time. For instance the reaction of mesitylene with benzhydrol in the presence of NaHSO4/SiO2 gave the corresponding triaryl methane in a quantitative yield. NaHSO4/SiO2 was regenerated by simple treatment and could

  在NaHSO 4 / SiO 2的存在下，开发了一种简单有效的从醇类将芳烃烷基化的方法。在短的反应时间内以高收率获得了各种三芳基甲烷。例如，在NaHSO 4 / SiO 2的存在下，1，3，5-三甲基苯与苯甲醇的反应以定量收率得到了相应的三芳基甲烷。NaHSO 4 / SiO 2通过简单处理即可再生，可以循环使用八次而不会损失活性。
• NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF
  申请人：NAM Ghilsoo

  公开号：US20100094006A1

  公开（公告）日：2010-04-15

  The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

  本发明涉及吡唑甲基胺基哌嗪衍生物及其药用盐，其作为钙通道调节剂具有有效性，以及其制造方法。本发明还涉及上述化合物的药用作用，用于治疗因其作为钙通道调节剂而产生的疾病。
• Tin exchanged heteropoly tungstate: An efficient catalyst for benzylation of arenes with benzyl alcohol
  作者：Ch. Ramesh Kumar、K.T. Venkateswara Rao、P.S. Sai Prasad、N. Lingaiah

  DOI：10.1016/j.molcata.2011.01.008

  日期：2011.3

  The partial exchange of tin with the protons of 12-tungstophosphoric acid (TPA) results in a highly active heterogeneous catalyst for benzylation of arenes with benzyl alcohol as benzylating agent. The catalysts were characterized by X-ray diffraction, Laser-Raman and FT-IR of pyridine adsorption. The catalytic activity depends significantly on the extent of tin exchanged with the protons of heteropoly tungstate. The characterization results suggest the presence of Lewis acidic sites by the exchange of tin. The catalyst with partial exchange of Sn showed high benzylation activity, which in turn related to variation in acidity of the catalysts. The catalyst is highly active for benzylation reaction irrespective of the nature of substituted arenes and benzyl alcohols. These catalysts are highly active compared to other acid catalysts used for benzylation of different arenes. The catalyst is easy to separate from reaction mixture and exhibit consistent activity upon reuse. The plausible reaction mechanism based on the role of both Lewis and Bronsted acid sites of the catalyst was discussed. (C) 2011 Elsevier B.V. All rights reserved.