TBN | 1083171-75-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: TBN
• 英文别名: 2-[[(1,1-dimethylethyl)-oxidoimino]-methyl]-3,5,6-trimethylpyrazine；tetramethylpyrazine nitrone；2-Propanamine, 2-methyl-N-[(3,5,6-trimethyl-2-pyrazinyl)methylene]-, N-oxide；N-tert-butyl-1-(3,5,6-trimethylpyrazin-2-yl)methanimine oxide
• CAS: 1083171-75-8
• 化学式: C₁₂H₁₉N₃O
• 分子量: 221.302
• InChiKey: BESRYENXPUCIID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-((tert-butylamino)methyl)-3,5,6-trimethylpyrazine 在 sodium tungstate 双氧水 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以36%的产率得到TBN
  参考文献：
  名称：

  [EN] NITRONE COMPOUNDS, PROCESS OF PREPARATION THEREOF, AND USE THEREOF IN MEDICAMENT MANUFACTURE
  [FR] COMPOSÉS DE NITRONE, PROCÉDÉ DE PRÉPARATION DE CEUX-CI, ET UTILISATION DE CEUX-CI DANS LA FABRICATION DE MÉDICAMENTS

  摘要：

  本发明提供了新型亚硝基甲酰胺，其制备和用途。新化合物具有以下公式：I。本发明的化合物具有强的抗氧化活性，并具有溶血性。这些化合物可用于治疗和/或预防由自由基过度产生和/或血栓形成引起的疾病。

  公开号：

  WO2009129726A1

文献信息

• NITRONE COMPOUNDS, PROCESS OF PREPARATION THEREOF, AND USE THEREOF IN MEDICAMENT MANUFACTURE
  申请人：Wang Yuqiang

  公开号：US20110034485A1

  公开（公告）日：2011-02-10

  The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and/or prevent diseases caused by overproduction of free radicals and/or formation of thrombus.

  本发明提供了新型的亚硝基甲酰亚胺，其制备和用途。这些新化合物的化学式为：I。本发明化合物具有强抗氧化活性和溶栓作用。这些化合物可用于治疗和/或预防由自由基过度产生和/或血栓形成引起的疾病。
• Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke
  作者：Yewei Sun、Jie Jiang、Zaijun Zhang、Pei Yu、Linda Wang、Changlin Xu、Wei Liu、Yuqiang Wang

  DOI：10.1016/j.bmc.2008.08.075

  日期：2008.10

  Ischemic stroke results from brain blood vessel blockage by thrombus, and produces neuronal cell damage and death. While thrombolytic therapy with tPA has achieved some success in clinic, the strategy of using neuroprotective agents to treat ischemic stroke has been disappointing thus far. In the present work, we synthesized TBN, a derivative of the clinically useful stroke drug TMP armed with a powerful free radical-scavenging nitrone moiety. TBN retains the thrombolytic activity of the parent TMP and possesses strong antioxidative properties. TBN demonstrates significant activity in the rat MCAo stroke model. The results suggest that design of molecules possessing both thrombolytic and neuroprotective properties may be a novel strategy for effective stroke therapeutics. (C) 2008 Elsevier Ltd. All rights reserved.