(Z)-N-tert-butyl-α-(pyridin-3-yl)-nitrone | 1001387-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (Z)-N-tert-butyl-α-(pyridin-3-yl)-nitrone
• 英文别名: C-3-pyridyl-N-tert-butyl-nitrone；2-Methyl-N-(3-pyridinylmethylene)-2-propanamine N-oxide；N-tert-butyl-1-pyridin-3-ylmethanimine oxide
• CAS: 1001387-10-5；72877-60-2
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: DVGXGOTVCRSYCP-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-N-tert-butyl-α-(pyridin-3-yl)-nitrone 、 反式-2-丁烯酸乙酯 反应 1.0h， 以74%的产率得到(3RS,4SR,5RS)-2-tert-butyl-3-(3-pyridyl)-4-carbethoxy-5-methyl-isoxazolidine
  参考文献：
  名称：

  Exploiting microwave-assisted neat procedures: synthesis of N-aryl and N-alkylnitrones and their cycloaddition en route for isoxazolidines

  摘要：

  Microwave irradiation allows increasing the speed of several reactions and also offers the possibility of eliminating poisoning organic solvents. In this work we report the microwave-assisted neat synthesis of alpha-phenyl-tert-butylnitrone (PBN) and other alkyl and aryl nitrones and also the rapid synthesis of isoxazolidines resulting from 1,3-dipolar cycloaddition of nitrones to ethyl trans-crotonate. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.101
• 作为产物：
  描述：

  2-Tert-butyl-3-pyridin-3-yloxaziridine 以 甲苯 为溶剂， 以99%的产率得到(Z)-N-tert-butyl-α-(pyridin-3-yl)-nitrone
  参考文献：
  名称：

  恶唑烷和烯烃的环加成反应合成新的3,5-二芳基异恶唑烷

  摘要：

  本文报告的新颖的环加成的过程Ç与各种烯烃的-aryloxaziridines，得到稳定的，五元杂环13 - 24。恶唑烷氮原子上的叔丁基的空间位阻是环加成反应的高立体选择性的原因。

  DOI：

  10.1016/j.tet.2007.10.044

文献信息

• BLOCK COPOLYMERS
  申请人：Symyx Technologies, Inc., a Delaware corporation

  公开号：US20020010267A1

  公开（公告）日：2002-01-24

  Block copolymers are disclosed having at least one polymer segment characterized by a high degree of control over molecular weight, particle size, polydispersity and polymer composition and architecture. The block copolymers feature at least on polymer segment produced using a controlled free radical polymerization process in an emulsion. Additional polymer segments can be generated using the controlled free radical emulsion process or any other polymerization process. The block copolymers include polymers having unique structure, such as stars, grafts, telechelics and macromonomers. Block copolymers having hard/soft and amphiphilic characteristics are also disclosed. The block copolymers may also include adducts with nitroxide control agents capable of free radical re-initiation.

  本发明揭示了至少具有一个聚合物段的嵌段共聚物，其特征是对分子量、粒径、聚分散度和聚合物组成和结构具有高度控制。该嵌段共聚物至少具有使用控制自由基乳液聚合过程生产的一个聚合物段。可以使用控制自由基乳液过程或任何其他聚合过程生成其他聚合物段。该嵌段共聚物包括具有独特结构的聚合物，例如星形、接枝、末端官能团和大分子单体。还揭示了具有硬/软和亲水性特征的嵌段共聚物。该嵌段共聚物还可以包括与亚硝酰控制剂的加合物，能够进行自由基再启动。
• Controlled free radical emulsion and water-based polymerizations and seeded methodologies
  申请人：——

  公开号：US20020013430A1

  公开（公告）日：2002-01-31

  Nitroxides having an alpha-carbon atom with a destabilizing moiety are effective control agents for emulsion and water-based polymerizations, including the formation of block copolymers from a wide range of monomers. The nitroxide radicals may be used as a free radical or as an adduct with a residue from the initiator. The emulsions have living characteristics, including the re-initiation of polymer chains. Also, a seeded process for emulsions, which includes the step-wise addition of monomer is disclosed, providing access to a wide range of initiator types.

  具有不稳定基团的α-碳原子的亚硝基自由基是乳液和水基聚合物的有效控制剂，包括从各种单体形成嵌段共聚物。亚硝基自由基可以作为自由基或与引发剂残基结合物一起使用。乳液具有活性特征，包括聚合物链的重新起始。此外，还公开了一种种子法乳液过程，其中包括逐步添加单体的步骤，从而提供了对各种引发剂类型的访问。
• CONTROLLED STABLE FREE RADICAL EMULSION POLYMERIZATION PROCESSES
  申请人：——

  公开号：US20020061988A1

  公开（公告）日：2002-05-23

  Controlled stable free radical emulsion polymerization processes employ nitroxide control agents having an alpha carbon atom bearing a destabilizing substituent such as hydrogen. The emulsion polymerizations have living characteristics, including the re-initiation of polymer chains, and provide a high degree of control over molecular weight, particle size, polydispersity and polymer composition and architecture. The processes are useful for the preparation of polymer emulsions, including block copolymers, star and graft copolymers, telechelics and macromonomers from a wide range of monomers.

  受控稳定自由基乳液聚合工艺采用的亚硝基控制剂具有一个带有氢等不稳定取代基的 α 碳原子。乳液聚合具有活特性，包括聚合物链的再引发，并可高度控制分子量、粒度、多分散性以及聚合物的组成和结构。这些工艺可用于制备聚合物乳液，包括由多种单体组成的嵌段共聚物、星型和接枝共聚物、远聚物和大单体。
• α-Phenyl-N-tert-butyl nitrone (PBN) derivatives: Synthesis and protective action against microvascular damages induced by ischemia/reperfusion
  作者：Sothea Kim、Guilherme V.M. de A. Vilela、Jalloul Bouajila、Ayres G. Dias、Fatima Z.G.A. Cyrino、Eliete Bouskela、Paulo R.R. Costa、Françoise Nepveu

  DOI：10.1016/j.bmc.2007.02.033

  日期：2007.5

  Nitrones 4-7, structurally related to PBN (1), were prepared by reaction of the corresponding aromatic aldehydes with N-tert-butyl hydroxylamine. The protective effects of these nitrones against microvascular damages in ischemia/reperfusion in the 'hamster cheek pouch' assay were studied and 1, as well as 4a, 4b, and 7 (derived from piperonal, O-benzyl vanillin, and furfural, respectively), showed to be more active than shark cartilage or a-tocopherol. No correlation was found between the protective effect of these nitrones and their log P (partition coefficient) or their capacity to trap OH and CH3 radicals. (c) 2007 Elsevier Ltd. All rights reserved.
• CONTROLLED FREE RADICAL EMULSION AND WATER-BASED POLYMERIZATIONS AND SEEDED METHODOLOGIES
  申请人：Symyx Technologies, Inc.

  公开号：EP1165625A1

  公开（公告）日：2002-01-02