(2-amino-4,5-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone | 153394-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-amino-4,5-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone
• 英文别名: 2-amino-4,5,3',4'-tetramethoxybenzophenone；2-amino-3',4,4',5-tetramethoxybenzophenone；(2-amino-4,5-dimethoxyphenyl)-(3,4-dimethoxyphenyl)methanone
• CAS: 153394-55-9
• 化学式: C₁₇H₁₉NO₅
• 分子量: 317.342
• InChiKey: QURQNGLMLPYTKL-UHFFFAOYSA-N

物化性质

• 沸点：
  522.8±50.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2-amino-4,5-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone 在 硫酸 、 sodium hydride 、 溶剂黄146 作用下， 反应 4.25h， 生成 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Studies on Disease-Modifying Antirheumatic Drugs:  Synthesis of Novel Quinoline and Quinazoline Derivatives and Their Anti-inflammatory Effect

  摘要：

  In the course of our study aimed at developing new types of DMARDs (disease-modifying antirheumatic drugs), we found that quinoline derivative 1a had a potent anti-inflammatory effect in an adjuvant arthritis (AA) rat model, starting from the potent bone resorption inhibitors justicidins as the lead compounds. Further modification of la was performed, and various quinoline and quinazoline derivatives having a heteroaryl moiety on the alkyl side chain at the 2-position of the skeleton were prepared. These compounds were evaluated for antiinflammatory effects using the AA rat model. Most of these compounds, especially those having an imidazole or a triazole moiety on the 2-alkyl chain, exhibited a potent effect. Among the compounds synthesized, ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-yl-methyl)quinoline-3-carboxylate (12d), having an ED(50) value of 2.6 mg/kg/day (anti-inflammatory effect in an AA rat model, po), was selected as a candidate for further investigation. In vitro, 12d inhibited mitogen-induced proliferation at 10(-7)-10(-5) M but not prostaglandin E(2) production at 10(-5) M. Moreover, 12d preferentially inhibited the IFN-gamma production by Th1-type clones over the IL-4 production by Th2-type clones. This preferential suppression of Th1 cytokine production is considered the essential immunomodulating action of 12d for the present. Synthesis and structure-activity relationships for this novel series of quinoline and quinazoline derivatives are detailed.

  DOI：

  10.1021/jm9509408
• 作为产物：
  描述：

  2-acetylamino-3',4,4'-5-tetramethoxybenzophenone 在 盐酸 、 溶剂黄146 作用下， 以89%的产率得到(2-amino-4,5-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone
  参考文献：
  名称：

  Process development of a disease-modifying antirheumatic drug, TAK-603, based on optimization of Friedel–Crafts reaction and selective substitution of a triazole ring

  摘要：

  A practical method for the preparation of TAK-603, an antirheumatic drug, has been developed. As a result of optimizing the Friedel-Crafts reaction in the presence of SnCl4/POCl3, 2-aminobenzophenone skeleton, the key intermediate of TAK-603, was formed with Pod yield. The selective substitution reaction of 1,2,4-triazole was accomplished using 4-amino-1,2,4-triazole and deamination. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.02.021

文献信息

• Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles
  作者：Jiuxi Chen、Leping Ye、Weike Su

  DOI：10.1039/c4ob00978a

  日期：——

  A palladium-catalyzed direct addition of arylboronic acids to unprotected 2-aminobenzonitriles has been developed, leading to a wide range of 2-aminobenzophenones with moderate to excellent yields. The transformation has broad scope and high functional group tolerance. Moreover, 2-oxoindoline-7-carbonitrile and indole-7-carbonitrile were applicable to this process for the construction of 7-benzoyl-2-oxoindolines and 7-benzoylindoles, respectively. Among the compounds examined, compound 4e possessed the most potent anticancer activity against H446 and HGC-27 in vitro, with IC50 values of 0.02 μmol L−1 and 0.09 μmol L−1, respectively, while compound 4a showed the best potent anticancer activity against SGC-7901 with an IC50 value of 0.01 μmol L−1. Furthermore, we also performed in silico molecular docking calculations to investigate the interaction mode and binding affinity between the examined compounds and their tubulin target.

  开发了一种钯催化的芳基硼酸与未保护的2-氨基苯腈直接加成反应，得到了一系列中等至优异收率的2-氨基二苯甲酮。该反应具有广阔的应用范围和高度的官能团耐受性。此外，2-氧代吲哚啉-7-腈和吲哚-7-腈也适用于该过程，分别用于构建7-苯甲酰基-2-氧代吲哚啉和7-苯甲酰基吲哚。在检测的化合物中，化合物4e对H446和HGC-27细胞具有最强的体外抗癌活性，IC50值分别为0.02 μmol L−1和0.09 μmol L−1，而化合物4a对SGC-7901细胞显示出最佳的抗癌活性，IC50值为0.01 μmol L−1。此外，我们还进行了计算机分子对接计算，以研究检测化合物与其微管蛋白靶点之间的相互作用模式和结合亲和力。
• Quinoline or quinazoline derivatives, their production and use
  申请人：Takeda Chemical Industries

  公开号：US05436247A1

  公开（公告）日：1995-07-25

  A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C--G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted or unsubstituted; each of rings A and B may have a substituent; n represents an integer from 1 to 4; k represents the integer 0 or 1, or a salt thereof, which serves well as an anti-inflammatory agent, particularly a therapeutic agent for arthritis.

  一种由通式表示的化合物：##STR1## 其中Y代表一个氮原子或C--G（G代表一个可能酯化的羧基）；环R是一个含氮的不饱和杂环基团，可以被取代或未取代；环A和环B中的每一个都可以有一个取代基；n代表一个从1到4的整数；k代表整数0或1，或其盐，可作为一种抗炎药物，特别是治疗关节炎的药物。
• Pharmaceutical composition containing quinoline or quinazoline
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05719157A1

  公开（公告）日：1998-02-17

  The present invention provides a pharmaceutical composition for inhibiting bone resorption or for preventing or treating osteoporosis which comprises a quinoline or quinazoine derivative as an active ingredient.

  本发明提供了一种用于抑制骨吸收或预防/治疗骨质疏松症的药物组合物，其包含喹啉或喹啉衍生物作为活性成分。
• TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions
  作者：Chieh-Kai Chan、Chien-Yu Lai、Cheng-Chung Wang

  DOI：10.1039/d0ob01507e

  日期：——

  we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes using cat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formed in situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope

  在本文中，我们报道了一种高效且温和的合成路线，用于使用cat由官能化的 2-氨基二苯甲酮与各种苯甲醛构建取代的喹唑啉。TMSOTf 和六甲基二硅氮烷 (HMDS) 在纯净、无金属和微波辐照条件下原位形成气态氨。这种合成方案提供了所需的喹唑啉，其底物范围广泛，产率良好。通过 X 射线单晶衍射分析证实了一些结构。
• Quinoline derivatives and pharmaceutical composition containing them
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05641788A1

  公开（公告）日：1997-06-24

  The present invention provides a novel quinoline derivative useful as an anti-inflammatory agent, particularly an agent for treating arthritis, or a salt thereof. The present invention also provides a composition, particularly an anti-inflammatory composition for pharmaceutical use, comprising the novel quinoline compound of formula (I): ##STR1## wherein G is an acyl group, optionally protected hydroxyalkyl group, amidated carboxyl group or halogen atom; X is an oxygen atom, optionally oxidized sulfur atom or --(CH.sub.2).sub.q -- in which q is an integer of 0 to 5; R is an optionally substituted amino group or optionally substituted heterocyclic group; each of the ring A and ring B may optionally be substituted; and k is 0 or 1.

  本发明提供了一种新型喹啉衍生物，作为一种抗炎药物，特别是用于治疗关节炎的药物，或其盐。本发明还提供了一种组合物，特别是用于制药用途的抗炎组合物，包括具有下式（I）的新型喹啉化合物：##STR1## 其中G是酰基，可选择保护的羟基烷基，酰胺化羧基或卤素原子；X是氧原子，可选择氧化硫原子或--(CH.sub.2).sub.q --，其中q为0到5的整数；R是可选择取代的氨基或可选择取代的杂环基；环A和环B中的每一个可选择被取代；k为0或1。