N-Acetylthyroxin | 1955-13-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetylthyroxin
• 英文别名: N-acetyl-thyroxine；N-Acetyl-T4; N-Acetyl-L-thyroxine；2-acetamido-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
• CAS: 1955-13-1
• 化学式: C₁₇H₁₃I₄NO₅
• 分子量: 818.912
• InChiKey: NERGVJCCFAPEMR-UHFFFAOYSA-N

物化性质

• 沸点：
  671.8±55.0 °C(Predicted)
• 密度：
  2.481±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-Acetyl-thyroxin-methylester 在 sodium hydroxide 作用下， 生成 N-Acetylthyroxin
  参考文献：
  名称：

  Ashley; Harington, Biochemical Journal, 1929, vol. 23, p. 1180

  摘要：

  DOI：

文献信息

• Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine <i>N</i> ‐Acetyltransferase NAT2
  作者：Louis P. Conway、Veronica Rendo、Mário S. P. Correia、Ingvar A. Bergdahl、Tobias Sjöblom、Daniel Globisch

  DOI：10.1002/anie.202005915

  日期：2020.8.17

  play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has been classified as an arylamine N‐acetyltransferase that mainly converts aromatic amines, hydroxylamines, and hydrazines. Herein, we demonstrate that the human arylamine N‐acetyltransferase NAT2 also acetylates aliphatic endogenous amines. Metabolomic analysis and chemical synthesis revealed increased

  N-乙酰基转移酶在异生物质（包括临床药物）的失活和清除中发挥着关键作用。NAT2被归类为芳胺N-乙酰转移酶，主要转化芳香胺、羟胺和肼。在此，我们证明人芳胺N-乙酰转移酶 NAT2 也乙酰化脂肪族内源胺。代谢组学分析和化学合成表明，与慢速乙酰化NAT2表型相比，表达快速乙酰化剂NAT2表型的人类细胞系中单乙酰化亚精胺和二乙酰化亚精胺的细胞内浓度增加。NAT2 对单乙酰化亚精胺的区域选择性N 8乙酰化回答了二乙酰亚精胺来源这一长期存在的问题。我们还发现了 NAT2 对结构多样的含烷基胺药物的选择性乙酰化，这可能会导致患者反应的变化。结果表明 NAT2 具有以前未知的功能和潜在的调节作用，我们建议应考虑对该酶进行重新分类。
• Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof
  申请人：Mousa Shaker A.

  公开号：US20090022806A1

  公开（公告）日：2009-01-22

  Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.

  本发明涉及治疗与血管生成有关的疾病的方法，包括向受试者施用有效量的聚合物纳米粒子形式的甲状腺激素激动剂、部分激动剂或其拮抗剂，以促进或抑制受试者的血管生成。本发明还涉及聚合物形式的甲状腺激素或甲状腺激素类似物的组合物。
• Nanoparticle and Polymer Formulations for Thyroid Hormone Analogs, Antagonists, and Formulations and Uses Thereof
  申请人：Davis Paul J.

  公开号：US20110142941A1

  公开（公告）日：2011-06-16

  Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.

  揭示了治疗与血管生成相关疾病的方法，包括给予有效量的聚合物纳米粒子形式的甲状腺激素激动剂、部分激动剂或其拮抗剂，以促进或抑制受试者的血管生成。还揭示了聚合物形式的甲状腺激素或甲状腺激素类似物的组成。
• Aminomethylfluorescein derivatives
  申请人：ABBOTT LABORATORIES

  公开号：EP0110186A1

  公开（公告）日：1984-06-13

  This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. This disclosure also relates to a novel class of tracer compounds employed as reagents in fluorescence polarization immunoassays.

  本公开涉及一种测定血清、血浆、脊髓液、羊膜液和尿液等生物液体中配体的方法和试剂。本公开还涉及在荧光偏振免疫分析中用作试剂的一类新型示踪化合物。
• TOPICAL COMPOSITION COMPRISING N-ACETYLALDOSAMINES OR N-ACETYLAMINO ACIDS
  申请人：Yu, Ruey J., Dr.

  公开号：EP1570840A2

  公开（公告）日：2005-09-07

  Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

  包含 N-乙酰-醛胺，N-乙酰基氨基酸和相关 N-乙酰基化合物的组合物可用于缓解或改善各种美容状况和皮肤病，包括与内在老化和/或外在老化相关的皮肤、指甲和头发的变化或损伤，以及由外在因素引起的变化或损伤。N-acetyl-aldosamines, N-acetylamino acids 和相关的 N-acetyl 组合物可进一步包含化妆品、药物或其他外用制剂，以增强或产生协同效应。