acetaldehyde methylphenylhydrazone | 15754-29-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: acetaldehyde methylphenylhydrazone
• 英文别名: syn-Acetaldehyd-N-methyl-phenylhydrazon；Acetaldehydmethylphenylhydrazon (syn)；N-[(E)-ethylideneamino]-N-methylaniline
• CAS: 15754-29-7
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: LNFGRTIISMMTJU-XCVCLJGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  acetaldehyde methylphenylhydrazone 在 diethyl(2,2,6,6-tetramethylpiperidino)aluminium 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 24.0h， 以32%的产率得到1-甲基吲哚
  参考文献：
  名称：

  Regioselective Fischer indole synthesis mediated by organoaluminum amides

  摘要：

  Amphiphilic reagents such as organoaluminum amides are found to be highly effective for the Fischer indole synthesis. In particular, diethylaluminum 2,2,6,6-tetramethylpiperidide (DATMP) is the reagent of choice for regioselective Fischer indole synthesis. For example, treatment of the (E)-N-methyl-N-phenylhydrazone of 5-methyl-3-heptanone with DATMP affords 3-sec-butyl-2-ethyl-1-methylindole as the sole isolable product; its Z-isomer affords 1,3-dimethyl-2-(2-methylbutyl)indole with high regioselectivity under similar reaction conditions.

  DOI：

  10.1021/jo00079a005
• 作为产物：
  描述：

  1-甲基-1-苯肼 、 乙炔 在 Ti(SC₆F₅)2(NMe₂)2(NHMe₂) 作用下， 以 甲苯 为溶剂， 以97%的产率得到acetaldehyde methylphenylhydrazone
  参考文献：
  名称：

  涉及1，1-二取代肼的分子间炔烃氨基化。

  摘要：

  [反应：见正文]已开发出两种易于制备的催化剂，用于1,1-二取代肼对炔烃的加氢胺化作用。该催化剂容易与末端炔烃和一些内部炔烃反应。如果肼带有芳基，则可以一锅法进行费歇尔环化。另外，描述了与乙炔的反应以产生大量的hydr。涉及乙炔和取代肼的催化反应在室温和1个大气压下于不到2小时内即可完成。

  DOI：

  10.1021/ol0201052

文献信息

• Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity
  申请人：Kume Masaharu

  公开号：US20090143414A1

  公开（公告）日：2009-06-04

  A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided. A compound represented by the general formula (I): wherein R X is a group represented by the formula: wherein R 1 is a hydrogen atom, optionally substituted alkyl, etc.; Z is —O—, —N(R 10 )—, etc.; R 10 is a hydrogen atom, alkyl, etc.; R 2 is a hydrogen atom, optionally substituted alkyl, etc.; R 18 is a hydrogen atom, optionally substituted alkyl, etc.; R 19 is optionally substituted alkyl, etc.; W 1 is an optionally substituted non-aromatic nitrogen-containing group; R 17 is a hydrogen atom, optionally substituted alkyl, etc.; R 3 and R 4 are independently a hydrogen atom, optionally substituted alkyl, etc.; X is —O—, —S—, or —N(R 12 )—, etc.; R 12 is a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc., its pharmaceutically acceptable salt, or a solvate thereof.

  提供了一种抑制EGF受体酪氨酸激酶和HER2酪氨酸激酶的化合物。该化合物由通式（I）表示：其中RX是由以下式子表示的基团：其中R1是氢原子，可选取代烷基等；Z是—O—，—N（R10）—等；R10是氢原子，烷基等；R2是氢原子，可选取代烷基等；R18是氢原子，可选取代烷基等；R19是可选取代烷基等；W1是可选取代非芳香族含氮基团；R17是氢原子，可选取代烷基等；R3和R4分别是氢原子，可选取代烷基等；X是—O—，—S—或—N（R12）—等；R12是氢原子，烷基等；A是苯基，可选取代基等，其药物可接受的盐或其溶剂化合物。
• QUINAZOLINE DERIVATIVES HAVING TYROSINE KINASE INHIBITORY ACTIVITY
  申请人：KUME Masaharu

  公开号：US20120123114A1

  公开（公告）日：2012-05-17

  A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided. A compound represented by the general formula (I): wherein R X is a group represented by the formula: wherein R 1 is a hydrogen atom, optionally substituted alkyl, etc.; Z is —O—, —N(R 10 )—, etc.; R 10 is a hydrogen atom, alkyl, etc.; R 2 is a hydrogen atom, optionally substituted alkyl, etc.; R 18 is a hydrogen atom, optionally substituted alkyl, etc.; R 19 is optionally substituted alkyl, etc.; W 1 is an optionally substituted non-aromatic nitrogen-containing group; R 17 is a hydrogen atom, optionally substituted alkyl, etc.; R 3 and R 4 are independently a hydrogen atom, optionally substituted alkyl, etc.; X is —O—, —S—, or —N(R 12 )—, etc.; R 12 is a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc., its pharmaceutically acceptable salt, or a solvate thereof.

  提供了一种同时抑制EGF受体酪氨酸激酶和HER2酪氨酸激酶的化合物。该化合物的普遍式表示为（I）：其中，RX是由以下式表示的基团：其中，R1是氢原子，可选地取代的烷基等；Z为—O—，—N(R10)—等；R10为氢原子，烷基等；R2为氢原子，可选地取代的烷基等；R18为氢原子，可选地取代的烷基等；R19为可选地取代的烷基等；W1为可选地取代的非芳香族含氮基团；R17为氢原子，可选地取代的烷基等；R3和R4分别为氢原子，可选地取代的烷基等；X为—O—，—S—或—N(R12)—等；R12为氢原子，烷基等；A为苯基，可选地具有取代基等，其药学上可接受的盐或其溶剂化物。
• AZO QUINOLINIUM COMPOUNDS COMPRISING A DISULPHIDE/THIOL UNIT, COMPOSITIONS CONTAINING SAME, PROCESS FOR DYEING KERATIN FIBRES AND DEVICE
  申请人：Daubresse Nicolas

  公开号：US20100263139A1

  公开（公告）日：2010-10-21

  The present invention relates to thiol/disulphide azo quinolinium compounds for dyeing keratin fibres. The invention relates to a dye composition comprising a particular thiol/disulphide azo quinolinium chromophore-containing thiol or disulphide dye, and to a process for dyeing keratin fibres such as the hair, using said composition. It similarly relates to novel particular thiol/disulphide azo quinolinium chromophore-containing dyes and to the uses thereof in dyeing keratin fibres. The dyeing process according to the invention makes it possible to dye keratin fibres without damaging them, in a manner which is particularly persistent with respect to shampooing operations and common attacks. Moreover, the novel dyes according to the invention extend the colour range to violets and blues. This process also makes it possible to dye bleached keratin fibres in a strong and chromatic manner.

  本发明涉及用于染色角蛋白纤维的巯基/二硫键偶氮喹啉化合物。本发明涉及一种染料组合物，包括特定的巯基/二硫键偶氮喹啉色团含有巯基或二硫键染料，并且涉及一种用于染色角蛋白纤维（如头发）的工艺，使用该组合物。它同样涉及新的特定巯基/二硫键偶氮喹啉色团含有染料及其在染色角蛋白纤维中的用途。本发明的染色工艺使得能够在不损害角蛋白纤维的情况下染色，其染色效果在洗发和常见的攻击方面特别持久。此外，本发明的新染料扩展了紫色和蓝色的色彩范围。此工艺还使得能够强烈和色彩鲜艳地染色漂白的角蛋白纤维。
• JPH05156243A
  申请人：——

  公开号：JPH05156243A

  公开（公告）日：1993-06-22
• US7967872B2
  申请人：——

  公开号：US7967872B2

  公开（公告）日：2011-06-28