2-(2-Furanylmethoxy)ethanol | 5831-58-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(2-Furanylmethoxy)ethanol
• 英文别名: 2-furfuryloxy-ethanol；fur-2-ylmethyl 2-hydroxyethyl ether；2-furanylmethoxyethanol；2-(furan-2-ylmethoxy)ethanol
• CAS: 5831-58-3
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: DAMRCQIFNHBTOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  42.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-Furanylmethoxy)ethanol 在 六氟异丙醇 、 tetrabutylammonium tetrafluoroborate 、 lithium perchlorate 、 4-甲基苯磺酸吡啶 、 溶剂黄146 作用下， 生成
  参考文献：
  名称：

  Torii 型电合成 α,β-不饱和酯的糠醇和氨基醇

  摘要：

  通过鸟居式酯电合成从生物质衍生的糠醛缀合物与乙二醇和氨基醇中获得多功能结构单元。产品可以通过两个连续的电化学步骤或通过一锅程序获得。

  DOI：

  10.1002/ejoc.202100605
• 作为产物：
  描述：

  2-(2-Furanylmethoxy)ethyl tetrahydropyranyl ether 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 生成 2-(2-Furanylmethoxy)ethanol
  参考文献：
  名称：

  Synthesis and biological activity of furanyl anti-juvenile hormonal compounds

  摘要：

  AbstractTwenty‐one synthetic compounds, containing one or more furan rings, were demonstrated to possess anti‐juvenile hormone (AJH) activity as evidenced by their induction of premature metamorphosis in the milkweed bug, Oncopeltus fasciatus (Dallas) by contact, topical application or fumigation. The ED50 of the four most active analogs required to induce precocious metamorphosis from 3rd‐instar nymphs by residue contact in a Petri dish compared favorably with that of precocene II (6,7‐dimethoxy‐2,2‐dimethyl 2H‐chromene) a naturally occurring phytochemical AJH. Precocious metamorphosis was fully reversible by co‐treatment with juvenile hormone (JH III) or JH analogs, demonstrating that the observed AJH activity resulted from an induced deficiency of juvenile hormone.

  DOI：

  10.1002/ps.2780430102

文献信息

• Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)
  申请人：Hoechst Marion Roussel, Inc.

  公开号：US05932571A1

  公开（公告）日：1999-08-03

  The present invention relates to novel N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)\x9b1,4!diazepan-1-yl)-2-(aryl)butyl)b enzamide derivatives of the formula: ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

  本发明涉及新型N-甲基-N-(4-(4-(1H-苯并咪唑-2-基)\x9b1,4!二氮杂环己烷-1-基)-2-(芳基)丁基)苯酰胺衍生物的公式：##STR1## 其立体异构体，以及其药学上可接受的盐，可用作组胺受体拮抗剂和速激肽受体拮抗剂。这类拮抗剂在过敏性鼻炎的治疗中很有用，包括季节性鼻炎和鼻窦炎；炎症性肠病，包括克罗恩病和溃疡性结肠炎；哮喘；支气管炎；以及呕吐。
• Aminal Diones as potassium channel openers
  申请人：——

  公开号：US20020147230A1

  公开（公告）日：2002-10-10

  Compounds of formula (I) 1 may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  化合物的化学式（I）可能在治疗由钾通道开放剂预防或改善的疾病中有用。还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
• Tandem Achmatowicz Rearrangement and Acetalization of 1-[5-(Hydroxyalkyl)-furan-2-yl]-cyclobutanols Leading to Dispiroacetals and Subsequent Ring-Expansion to Form 6,7-Dihydrobenzofuran-4(5<i>H</i>)-ones
  作者：Hui Peng、Wenkun Luo、Huanfeng Jiang、Biaolin Yin

  DOI：10.1021/acs.joc.8b01765

  日期：2018.10.19

  dispiroacetals 4 bearing a cyclobutane motif via tandem Achmatowicz rearrangement and acetalization of 1-[5-(hydroxyalkyl)-furan-2-yl]-cyclobutanols 3 with m-CPBA as the oxidant and AgSbF6 as an additive to promote the cyclization step in an aqueous medium. Dispiroacetals 4 could subsequently undergo Lewis acid-catalyzed ring expansion and skeletal rearrangement to afford 6,7-dihydro-5H-benzofuran-4-ones 5.

  在此，我们报告dispiroacetals合成的单罐协议4经由串联Achmatowicz重排和1- [5-（羟烷基） -呋喃-2-基]的缩醛轴承环丁烷基序-cyclobutanols 3与米-CPBA作为氧化剂和AgSbF 6作为添加剂，以促进在水性介质中的环化步骤。二螺缩醛4随后可以进行路易斯酸催化的环扩展和骨架重排，以提供6,7-dihydro-5 H -benzofuran-4-ones 5。
• Substituted piperidines useful for the treatment of allergic diseases
  申请人：Aventis Pharmaceuticals, Inc.

  公开号：US06329392B1

  公开（公告）日：2001-12-11

  The present invention relates to novel substituted piperidine derivatives of the formula stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.

  本发明涉及一种新型的取代哌啶衍生物，其化学式为其立体异构体和药学上可接受的盐，可用作组胺受体拮抗剂和速激肽受体拮抗剂。这类拮抗剂在治疗过敏性疾病中很有用，包括：季节性鼻炎、过敏性鼻炎和鼻窦炎。
• Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino)
  申请人：Hoechst Marion Roussel, Inc.

  公开号：US05922737A1

  公开（公告）日：1999-07-13

  The present invention relates to novel substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)-2-(aryl)butyl )benzamide derivatives of the formula: ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

  本发明涉及一种新型的取代N-甲基-N-(4-(4-(1H-苯并咪唑-2-基氨基)哌啶-1-基)-2-(芳基)丁基)苯甲酰衍生物，其化学式为：##STR1## 其立体异构体，以及其药学上可接受的盐，可用作组胺受体拮抗剂和催吐受体拮抗剂。这些拮抗剂在过敏性鼻炎的治疗中有用，包括季节性鼻炎和鼻窦炎；炎症性肠道疾病，包括克罗恩病和溃疡性结肠炎；哮喘；支气管炎；以及呕吐。