di-(4-tert-butylphenyl) carbonate | 2561-97-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: di-(4-tert-butylphenyl) carbonate
• 英文别名: bis(4-t-butylphenyl) carbonate；t-butylphenyl carbonate；Di-(4-tert.-butyl-phenyl)-carbonat；Kohlensaeure-bis-<4-tert.-butyl-phenylester>；carbonic acid bis-(4-tert-butyl-phenyl ester)；Kohlensaeure-bis-(4-tert-butyl-phenylester)；Bis-(4-tert.-butyl-phenyl)-carbonat；di(p-t-butylphenyl) carbonate；Bis(4-(tert-butyl)phenyl) carbonate；bis(4-tert-butylphenyl) carbonate
• CAS: 2561-97-9
• 化学式: C₂₁H₂₆O₃
• 分子量: 326.436
• InChiKey: WMEZDESZXBGWCU-UHFFFAOYSA-N

物化性质

• 沸点：
  403.0±34.0 °C(Predicted)
• 密度：
  1.045±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氯仿 、 4-叔丁基苯酚 在 吡啶 、 氧气 、 sodium carbonate 作用下， 以 水 为溶剂， 反应 3.0h， 以57%的产率得到di-(4-tert-butylphenyl) carbonate
  参考文献：
  名称：

  CARBONATE DERIVATIVE PRODUCTION METHOD

  摘要：

  本发明的目的是以安全高效的方式提供生产碳酸酯衍生物的方法。根据本发明的生产碳酸酯衍生物的方法的特征在于，在含有一种或多种来自氯原子、溴原子和碘原子组成的卤素原子的C1-4卤代烃、含有亲核功能基团的化合物和特定碱的组合物中，在氧气存在下照射光线。

  公开号：

  US20200079723A1

文献信息

• Oxidative carbonylation of monohydroxy aryl compounds by methyl formate
  申请人：Bayer MaterialScience AG

  公开号：EP2781503A1

  公开（公告）日：2014-09-24

  The field of the present invention relates to a process for continuously preparing alkylaryl carbonates and diarylcarbonates from methyl formate and at least one monohydroxy aryl compound in the presence of catalysts, and to the use thereof for preparation of polycarbonates.

  本发明领域涉及一种在催化剂存在下，从甲酸甲酯和至少一种单羟基芳基化合物连续制备烷基芳基碳酸酯和二芳基碳酸酯的方法，以及其用于制备聚碳酸酯的用途。
• 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
  申请人：McAlpine James Indrawan

  公开号：US20050090529A1

  公开（公告）日：2005-04-28

  3,5 disubstituted indazole compounds with substituted nitrogen bearing 5-membered heterocycles in the 3-position that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

  描述了在3-位置带有取代氮的5-成员杂环的3,5-二取代吲唑化合物，这些化合物调节和/或抑制细胞增殖，如蛋白激酶活性。这些化合物和含有它们的药物组合物能够调节和/或抑制介导CDK依赖性疾病的不需要的细胞增殖。该发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及通过给予这些化合物的有效量来治疗癌症以及与不需要的血管生成和/或细胞增殖相关的其他疾病状态，如糖尿病视网膜病变、新生血管性青光眼、类风湿性关节炎和牛皮癣的方法。
• PROCESSES FOR PRODUCING ARYL CARBAMATES, ISOCYNATES AND POLYUREAS USING DIARYL CARBONATE
  申请人：Dai Shenghong A.

  公开号：US20130079542A1

  公开（公告）日：2013-03-28

  A preparation of aryl carbamates can be achieved readily by carbonylation of an aromatic polyamine compound with diphenyl carbonate (DPC) using a combination of an organic acid and a tertiary amine as a catalyst. Aryl carbamate can be converted into 4,4′-diphenylmethane diisocyanate (MDI) by heating it at about 200 to about 230° C. in a non-polar solvent containing inhibitor such as benzoyl chloride. In another application, trans-ureation of biscarbamates with an amine or mixed amines is found to be extremely facile in a polar solvent such as dimethyl sulfoxide (DMSO) and tetramethylene sulfone (TMS) in absence of any catalyst to make polyurea polymers of high molecular weights. Thus, efficient green-chemistry processes based on biscarbamates in making isocyanate products as well as urea prepolymers, urea elastomers and urea plastics have been developed in all in excellent yields without using reactive phosgene or 4,4′-diphenylmethane diisocyanate separately in the trans-ureation polymerizations.

  芳基氨基甲酸酯的制备可通过芳香族多胺化合物与二苯基碳酸酯（DPC）在有机酸和三级胺的催化剂作用下进行羰基化而轻松实现。将芳基氨基甲酸酯加热至约200至230°C，在含有苯甲酰氯等抑制剂的非极性溶剂中，可将其转化为4,4′-二苯甲烷二异氰酸酯（MDI）。在另一个应用中，使用极性溶剂如二甲基亚砜（DMSO）和四甲基砜（TMS）中，通过与胺或混合胺进行双氨基甲酸酯的转尿素化，在无催化剂的情况下制备高分子量的聚脲聚合物是非常容易的。因此，基于双氨基甲酸酯的高效绿色化学过程已经开发出以优异产率制备异氰酸酯产品、尿素预聚合物、尿素弹性体和尿素塑料的方法，而无需在转尿素聚合过程中单独使用反应性的光气或4,4′-二苯甲烷二异氰酸酯。
• CATIONIC BIS-UREA COMPOUNDS AS EFFECTIVE ANTIMICROBIAL AGENTS
  申请人：Coady Daniel Joseph

  公开号：US20130281515A1

  公开（公告）日：2013-10-24

  A cationic bis-urea compound is disclosed of formula (1): wherein: each m is independently an integer of 0 to 4, each k is independently 0 or 1, each Z′ is a monovalent radical independently selected from the group consisting of hydroxyl (*—OH), carboxyl (*—COOH), cyano (*—CN), nitro (*—NO 2 ), sulfonate (*—SO 3 − ), trifluoromethyl (*—CF 3 ), halides, amine groups, ketone groups, alkyl groups comprising 1 to 6 carbons, alkoxy groups comprising 1 to 6 carbons, thioether groups comprising 1 to 6 carbons, and combinations thereof, each L′ is independently a divalent alkylene group comprising 1 to 6 carbons, wherein a *-[-L′-] k - is a single bond when k is 0, each Y′ is independently a monovalent non-polymeric radical comprising a positive charged amine, and each X′ is independently a negative charged counterion.

  揭示了一种带正电的双脲化合物，其化学式为（1）：其中：每个m独立地是0到4的整数，每个k独立地是0或1，每个Z′是从羟基（*—OH）、羧基（*—COOH）、氰基（*—CN）、硝基（*—NO2）、磺酸根（*—SO3−）、三氟甲基（*—CF3）、卤素、胺基、酮基、含有1至6个碳的烷基、含有1至6个碳的烷氧基、含有1至6个碳的硫醚基和它们的组合中独立选择的一价基团，每个L′独立地是由1至6个碳组成的二价烷基，其中当k为0时，*-[-L′-]k-是单键，每个Y′独立地是包含正电荷胺基的一价非聚合物基团，每个X′独立地是带负电荷的对离子。
• PROCESS FOR PREPARING DIARYL CARBONATES FROM DIALKYL CARBONATES
  申请人：Düx Andre

  公开号：US20100010252A1

  公开（公告）日：2010-01-14

  The invention provides a process for preparing diaryl carbonates from dialkyl carbonates and aromatic hydroxyl compounds using at least two reaction columns, a process section for recovering the dialkyl carbonate used in the reaction and for removing the alcohol of reaction, one or more process steps for removing the by-products obtained in the process which have a boiling point between that of the dialkyl carbonate and that of the alkyl aryl carbonate formed during the preparation of the diaryl carbonate, and a process step for further purification of the diaryl carbonate obtained from the reaction columns.

  该发明提供了一种从二烷基碳酸酯和芳香羟基化合物制备二芳基碳酸酯的过程，使用至少两个反应柱，一个用于回收反应中使用的二烷基碳酸酯并去除反应中的醇的工艺部分，一个或多个用于去除在过程中获得的副产物的工艺步骤，这些副产物的沸点介于二烷基碳酸酯和制备二芳基碳酸酯期间形成的烷基芳基碳酸酯之间，以及一个用于对从反应柱中获得的二芳基碳酸酯进行进一步纯化的工艺步骤。