ethyl <(S)-1-phenylethyl>iminoethanoate | 37662-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl <(S)-1-phenylethyl>iminoethanoate
• 英文别名: ((S)-1-phenylethylimino)-acetic acid ethyl ester；ethyl [[(S)-1-phenylethyl]imino]ethanoate；((S)-1-phenyl-ethylimino)-acetic acid ethyl ester；D-α-Methylbenzyliminoglyoxalsaeureethylester；ethyl ((S)-1-phenylethyl)iminoethanoate；Ethyl L-(alpha-Methylbenzylimino)acetate；ethyl 2-[(1S)-1-phenylethyl]iminoacetate
• CAS: 37662-06-9
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: VHFZIBNRJPBOBX-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl <(S)-1-phenylethyl>iminoethanoate 在 platinum on activated charcoal 水 、 氢气 、 三氟乙酸 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 46.0h， 生成 ethyl cis-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate
  参考文献：
  名称：

  Bailey, Patrick D.; Wilson, Robert D.; Brown, George R., Journal of the Chemical Society. Perkin transactions I, 1991, # 5, p. 1337 - 1340

  摘要：

  DOI：
• 作为产物：
  描述：

  乙醛酸乙酯 、 (S)-(-)- α-甲基苄胺 反应 1.0h， 生成 ethyl <(S)-1-phenylethyl>iminoethanoate
  参考文献：
  名称：

  β-酮基酯与硝基烯烃不对称迈克尔反应的2-基于氮杂降冰片烷的氨基醇有机催化剂

  摘要：

  使用新设计的光学活性的基于2-氮杂降冰片烷的氨基醇有机催化剂，对β-酮酯向硝基烯烃进行了高对映选择性的迈克尔加成反应，从而以良好的化学收率（高达99％）和立体选择性（高达dr = 91：9，最高可达91％ee）。

  DOI：

  10.1002/ejoc.201900308

文献信息

• Asymmetric synthesis of α-amino-acids from diastereomeric metal–imine complexes
  作者：J. Y. Chenard、D. Commereuc、Y. Chauvin

  DOI：10.1039/c39720000750

  日期：——

  A new route to optically active α-amino-acids has been achieved by treating halogen compounds with iron(0) and nickel(0) diastereomeric complexes of α-methylbenzyliminoglyoxylic acid ethyl ester.

  通过用α-甲基苄基亚氨基乙醛酸乙酯的铁（0）和镍（0）非对映异构体配合物处理卤素化合物，已经获得了一种具有旋光活性的α-氨基酸的新途径。
• Antibodies to argatroban derivatives and their use in therapeutic and diagnostic treatments
  申请人：ConjuChem, Inc.

  公开号：US06440417B1

  公开（公告）日：2002-08-27

  Antibodies to a therapeutic agent and its derivatives and conjugates are disclosed, including antibodies to argatroban and its derivatives and conjugates. The antibodies are useful as reagents in assays and diagnostic kits for determining the concentration of a therapeutic agent or its derivatives and conjugates in biological samples, and further have therapeutic uses in treatment for potential toxicity associated with stable therapeutic conjugates and derivatives, both in vivo and ex vivo.

  本文介绍了一种针对治疗剂及其衍生物和结合物的抗体，包括针对阿加曲班及其衍生物和结合物的抗体。这些抗体可用作试剂，在测定生物样品中治疗剂或其衍生物和结合物的浓度方面的诊断试剂盒中使用，并且在体内和体外的稳定治疗结合物和衍生物潜在毒性的治疗中具有治疗用途。
• Amides as BACE inhibitors
  申请人：Eli Lilly and Company

  公开号：US07618978B2

  公开（公告）日：2009-11-17

  The present invention provides BACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation.

  本发明提供了式(I)的BACE抑制剂，以及使用它们的方法，中间体和制备它们的方法。
• BIOLOGICALLY ACTIVE AMIDES
  申请人：Peterson John Matthew

  公开号：US20110230497A1

  公开（公告）日：2011-09-22

  The present invention is directed to biologically active amides which are ligands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from certain disorders which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from certain disorders.

  本发明涉及生物活性酰胺，其是NPY Y5受体的配体。该发明还提供了一种制药组合物，包括本发明化合物的治疗有效量和药学可接受载体。本发明还提供了治疗患有某些疾病的受试者的方法，包括向受试者投予本发明化合物的量。此外，本发明还提供了一种利用本发明化合物制造治疗患有某些疾病的受试者的药物的用途。
• The aza-Diels–Alder reaction protocol—a useful approach to chiral, sterically constrained α-amino acid derivatives
  作者：Sophie K Bertilsson、Jenny K Ekegren、Stefan A Modin、Pher G Andersson

  DOI：10.1016/s0040-4020(01)00531-2

  日期：2001.7

  Different types of polycyclic alpha -amino acid derivatives are prepared from chiral imines by using well-established aza-Diels-Alder reaction conditions. Simply by varying the diene moiety, different products such as spirocyclic compounds 8 and 9, anthracene 10, and tetrahydroquinolines 15-21 are formed. (C) 2001 Elsevier Science Ltd. All rights reserved.