nicotinoyloxyethylamine hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: nicotinoyloxyethylamine hydrochloride
• 英文别名: nicotinic acid-(2-amino-ethyl ester); dihydrochloride；Nicotinsaeure-(2-amino-aethylester); Dihydrochlorid；2-aminoethyl nicotinate dihydrochloride；2-Aminoethyl pyridine-3-carboxylate;hydrochloride；2-aminoethyl pyridine-3-carboxylate;hydrochloride
• 化学式: C₈H₁₀N₂O₂*2ClH
• 分子量: 239.101
• InChiKey: PAUOJXCTNKFZRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.62
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  四氯化碳 、 nicotinoyloxyethylamine hydrochloride 生成 N-(2-羟乙基)烟酰胺
  参考文献：
  名称：

  羧酸的伯乙醇酰胺和相应的氨基乙基酯之间的重排。

  摘要：

  DOI：

  10.1021/ja01194a003
• 作为产物：
  描述：

  烟酸甲酯 在 盐酸 、 乙醇 作用下， 生成 nicotinoyloxyethylamine hydrochloride
  参考文献：
  名称：

  羧酸的伯乙醇酰胺和相应的氨基乙基酯之间的重排。

  摘要：

  DOI：

  10.1021/ja01194a003

文献信息

• Pharmaceutical formulations for parenteral use
  申请人：University of Florida

  公开号：US04983586A1

  公开（公告）日：1991-01-08

  Aqueous parenteral solutions of drugs which are insoluble or only sparingly soluble in water and/or which are unstable in water, combined with hydroxypropyl-.beta.-cyclodextrin, provide a means for alleviating problems associated with drug precipitation at the injection site and/or in the lungs or other organs following parenteral administration.

  将不溶或在水中仅微溶或在水中不稳定的药物与羟丙基-β-环糊精结合，提供了一种缓解与药物在注射部位沉淀以及/或在注射后在肺部或其他器官中沉淀相关问题的方法。
• Studies on hypolipidemic agents. I. Synthesis and pharmacological properties of nicotinic acid-ethanolamine derivatives.
  作者：KUNIO SEKI、TAKEHIKO YAMASHITA、JUNICHI ISEGAWA、MINORU FUKUDA、HIROSHI SHIMAMURA、MASAHIKO OHKI

  DOI：10.1248/cpb.31.4116

  日期：——

  A series of nicotinic acid-ethanolamine derivatives was synthesized and evaluated pharmacologically and biochemically in mice and rats. Many compounds showed considerable hypolipidemic activity in two models : hypercholesterolemic mice and hypertriglyceridemic rats. The results clarified some structure-activity relationships ; there was an increase in efficacy resulting from the introduction of alkyl or aryl groups on the nitrogen of the ethanolamine part. Furthermore, it was clearly shown that coupling of ethanolamines with nicotinic acid (NA) resulted in a marked decrease in toxicity. Among the compounds tested, 2-(N-isopropyl-N-nicotinoylamino) ethyl nicotinate (20) was found to possess more favorable pharmacological and toxicological profiles than NA. Studies on 20 indicated that its hypolipidemic effect might be attributable to NA released by hydrolysis in vivo of the ester linkage. After administration of 20, the maximum serum level of free NA was approximately 4 times lower and the persistence of NA level in the serum was longer than that of the NA-treated group.

  合成了一系列烟酸-胆胺衍生物，并在小鼠和大鼠中进行了药理学和生物化学评价。许多化合物在两种模型中显示出相当强的降血脂活性：高胆固醇血症小鼠和高甘油三酯血症大鼠。结果阐明了一些构效关系；通过在胆胺部分的氮原子上引入烷基或芳基团，效力得到了提高。此外，清楚地表明，将胆胺与烟酸（NA）结合，毒性显著降低。在测试的化合物中，2-（N-异丙基-N-烟酰胺）乙基烟酸酯（20）被发现具有比NA更有利的药理学和毒理学特性。对20的研究表明，其降血脂作用可能归因于酯键在体内水解释放的NA。给予20后，游离NA的血清峰值水平约为NA组的四分之一，且NA在血清中的持续时间更长。
• Redox systems for brain-targeted drug delivery
  申请人：University of Florida

  公开号：US05017566A1

  公开（公告）日：1991-05-21

  Inclusion complexes of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of .beta.- and .gamma.-cyclodextrin with the reduced, biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine.revreaction.pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation. The redox inclusion complexes also provide a means for decreasing initial drug concentrations in the lungs after administration of the systems, leading to decreased toxicity. In selected instances, complexation results in substantially improved water solubility of the redox systems as well.

  羟丙基、羟乙基、葡萄糖基、麦芽糖基和麦芽三糖基衍生物与β-和γ-环糊精的包含复合物，与还原的、可生物氧化的、能穿透血脑屏障的、脂质形式的二氢吡啶.反应.pyridinium盐氧化还原系统形成脑靶向药物输送的一种手段，用于稳定氧化还原系统，特别是对抗氧化作用。氧化还原包含复合物还提供了一种减少系统给药后肺部初始药物浓度的手段，从而降低毒性。在某些情况下，复合作用显著提高了氧化还原系统的水溶性。
• Bras; Skorodumow, Zhurnal Obshchei Khimii, 1956, vol. 26, p. 770,772, 773; engl. Ausg. S. 881
  作者：Bras、Skorodumow

  DOI：——

  日期：——