N-2,4-hexadienoylglycine | 19267-98-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-2,4-hexadienoylglycine
• 英文别名: 2-[[(2E,4E)-hexa-2,4-dienoyl]amino]acetic acid
• CAS: 19267-98-2
• 化学式: C₈H₁₁NO₃
• 分子量: 169.18
• InChiKey: NRJHPYHCLIMQOK-MQQKCMAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-2,4-hexadienoylglycine 在 sodium acetate 、 potassium carbonate 作用下， 以 乙醇 、 水 、 甲胺 为溶剂， 反应 4.0h， 生成 3,5-dihydro-5-(4-hydroxybenzylidene)-3-methyl-2-penta-1,3-dien-1-yl-4H-imidazol-4-one
  参考文献：
  名称：

  Synthesis and Spectroscopic Studies of Model Red Fluorescent Protein Chromophores

  摘要：

  Here we describe the synthesis and spectroscopic characterization of two compounds designed to model the chromophore in DsRed, a red fluorescent protein. Comparison with model green fluorescent protein (GFP) chromophores indicates that the additional conjugation in the DsRed models can account, in part, for the red-shifted absorption and emission properties of DsRed compared to those of GFP. In contrast to the GFP models, the DsRed models are fluorescent with quantum yields of 0.002-0.01 in CHCl3.

  DOI：

  10.1021/ol0200403
• 作为产物：
  描述：

  山梨酸 在 三乙胺 作用下， 以 phosphate buffer 、 乙醚 、 乙酸乙酯 为溶剂， 反应 1.5h， 生成 N-2,4-hexadienoylglycine
  参考文献：
  名称：

  Synthesis and Spectroscopic Studies of Model Red Fluorescent Protein Chromophores

  摘要：

  Here we describe the synthesis and spectroscopic characterization of two compounds designed to model the chromophore in DsRed, a red fluorescent protein. Comparison with model green fluorescent protein (GFP) chromophores indicates that the additional conjugation in the DsRed models can account, in part, for the red-shifted absorption and emission properties of DsRed compared to those of GFP. In contrast to the GFP models, the DsRed models are fluorescent with quantum yields of 0.002-0.01 in CHCl3.

  DOI：

  10.1021/ol0200403

文献信息

• Synthesis and Spectroscopic Studies of Model Red Fluorescent Protein Chromophores
  作者：Xiang He、Alasdair F. Bell、Peter J. Tonge

  DOI：10.1021/ol0200403

  日期：2002.5.1

  Here we describe the synthesis and spectroscopic characterization of two compounds designed to model the chromophore in DsRed, a red fluorescent protein. Comparison with model green fluorescent protein (GFP) chromophores indicates that the additional conjugation in the DsRed models can account, in part, for the red-shifted absorption and emission properties of DsRed compared to those of GFP. In contrast to the GFP models, the DsRed models are fluorescent with quantum yields of 0.002-0.01 in CHCl3.