1,6-dimethyl-4-methylamino-piperidin-2-one | 112971-22-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,6-dimethyl-4-methylamino-piperidin-2-one
• 英文别名: 1,6-Dimethyl-4-methylamino-piperidin-2-on；1,6-Dimethyl-4-(N-methylamino)-piperidon-(2)；1,6-Dimethyl-4-(methylamino)-2-piperidone；1,6-dimethyl-4-(methylamino)piperidin-2-one
• CAS: 112971-22-9
• 化学式: C₈H₁₆N₂O
• 分子量: 156.228
• InChiKey: MHUBFRNWYPTUCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,6-dimethyl-4-methylamino-piperidin-2-one 生成 1,6-Dimethyl-5,6-dihydro-pyridon-(2)
  参考文献：
  名称：

  THE SPECTRA OF SATURATED AND α–β UNSATURATED SIX-MEMBERED LACTAMS

  摘要：

  描述了一些饱和和不饱和的六元内酰胺的紫外线和红外线光谱，并讨论了3μ和6μ区域的不寻常特征。对比了这些光谱与先前归因于α-β不饱和内酰胺的光谱。

  DOI：

  10.1139/v54-088
• 作为产物：
  描述：

  山梨酸 、 甲胺 在 水 作用下， 生成 1,6-dimethyl-4-methylamino-piperidin-2-one
  参考文献：
  名称：

  THE SPECTRA OF SATURATED AND α–β UNSATURATED SIX-MEMBERED LACTAMS

  摘要：

  描述了一些饱和和不饱和的六元内酰胺的紫外线和红外线光谱，并讨论了3μ和6μ区域的不寻常特征。对比了这些光谱与先前归因于α-β不饱和内酰胺的光谱。

  DOI：

  10.1139/v54-088

文献信息

• [EN] 2-PYRIDINE ALKYNE DERIVATIVES USEFUL FOR TREATING PAIN<br/>[FR] DERIVES DE 2-PYRIDINE ALKYNE SERVANT AU TRAITEMENT DE LA DOULEUR
  申请人：EURO CELTIQUE SA

  公开号：WO2005007641A1

  公开（公告）日：2005-01-27

  The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson’s disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington’s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.

  本发明提供了化合物式(I)的化合物：（其中R1，Q，A和R2在此披露）或其药学上可接受的盐（“吡啶-炔基化合物”）；包括有效量的吡啶-炔基化合物的制药组合物；以及治疗或预防动物的疼痛、尿失禁、成瘾障碍、帕金森病、帕金森综合症、焦虑、癫痫、癫痫发作、中风、瘙痒症、精神病、认知障碍、记忆缺陷、脑功能受限、亨廷顿舞蹈症、肌萎缩侧索硬化症、痴呆、视网膜病、肌肉痉挛、偏头痛、呕吐、运动障碍或抑郁症的方法，包括向需要治疗的动物中投与有效量的吡啶-炔基化合物。
• KHEDDIS B.; BAHIBAH D.; HAMDI M.; PERIE J.-J., BULL. SOC. CHIM. FRANCE, 1981, PART. 2, NO 3-4, 135-140
  作者：KHEDDIS B.、 BAHIBAH D.、 HAMDI M.、 PERIE J.-J.

  DOI：——

  日期：——
• KHEDDIS, BAYA;BAHIBAH, DJIDA;HAMDI, MAAMAR, J. IRAQI CHEM. SOC., 1980, 5, N ISSUE, 187-193
  作者：KHEDDIS, BAYA、BAHIBAH, DJIDA、HAMDI, MAAMAR

  DOI：——

  日期：——
• THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
  申请人：Kyle Donald J.

  公开号：US20100256111A1

  公开（公告）日：2010-10-07

  The invention provides a compound of formula (I): (where R 1 , Q, A and R 2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
• US7767699B2
  申请人：——

  公开号：US7767699B2

  公开（公告）日：2010-08-03