2-methyl-N-(4-sulfamoyl-phenyl)-butyramide | 349576-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-N-(4-sulfamoyl-phenyl)-butyramide
• 英文别名: 2-methyl-N-(4-sulfamoylphenyl)butanamide
• CAS: 349576-90-5
• 化学式: C₁₁H₁₆N₂O₃S
• mdl: MFCD02861382
• 分子量: 256.326
• InChiKey: AGVRSARENXIYBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  97.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-甲基丁酰氯 、 磺胺 在 吡啶 作用下， 以 丙酮 为溶剂， 反应 12.0h， 以82%的产率得到2-methyl-N-(4-sulfamoyl-phenyl)-butyramide
  参考文献：
  名称：

  [EN] SULFANYLAMIDE DERIVATIVES, USES THEREOF AND COMPOSITIONS COMPRISING THEM
  [FR] DÉRIVÉS DE SULFANYLAMIDE, LEURS UTILISATIONS ET COMPOSITIONS LES CONTENANT

  摘要：

  本发明涉及一类磺胺基苯甲酰胺衍生物，其化学式为(I)，作为抗癫痫药物，其中R1选自可选取的取代的C4-C9烷基、可选取的取代的C6-C10芳基、可选取的取代的C6-C10烷基芳基和可选取的取代的C5-C10杂环芳基；R2选自-H和可选取的取代的C1-C6烷基；R3和R4中的每一个，独立地选自-H、可选取的取代的C1-C6烷基、可选取的取代的C6-C10芳基和可选取的取代的C5-C10杂环芳基；n为0、1、2、3或4。这些衍生物已经制备，并评估了它们的抗癫痫特性以控制癫痫发作。

  公开号：

  WO2011033518A1

文献信息

• Syntheses and Evaluation of Anticonvulsant Profile and Teratogenicity of Novel Amide Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide
  作者：Naama Hen、Meir Bialer、Bogdan Wlodarczyk、Richard H. Finnell、Boris Yagen

  DOI：10.1021/jm100170w

  日期：2010.5.27

  Despite the availability of 14 new antiepileptic drugs (AEDs), about 30% of epileptic patients are not seizure-free. Consequently there is substantial need to develop new effective AEDs. A novel class of aromatic amides composed of phenylacetic acid or branched aliphatic carboxylic acids, with five to nine carbons in their carboxylic moiety, and aminobenzenesulfonamide were synthesized and evaluated in the anticonvulsant rat-maximal electroshock (MES) and subcutaneous metrazol seizure (scMet) tests. Fourteen of the synthesized amides had an anticonvulsant ED(50) of <50 mg/kg in the rat-MES test. The amides 2-methyl-N-(4-sulfamoylphenyl)butyramide (10), 2-ethyl-N-(4-sulfamoylphenyl)butyramide (11), and 3,3-dimethyl-N-(4-sulfamoylphenyl)butyramide (15) were the most potent compounds possessing MES-ED(50) values of 7.6, 9.9, and 9.4 mg/kg and remarkable protective index (PI = TD(50)/ ED(50)) values of 65.7, 50.5, and 53.2, respectively. These potent sulfanylamides caused neural tube defects only at doses markedly exceeding their effective dose. The anticonvulsant properties of these compounds make them potential candidates for further development as new, potent, and safe AEDs.
• LITHOGRAPHIC PRINTING PLATE PRECURSOR, LITHOGRAPHIC PRINTING PLATE PLATEMAKING METHOD, AND POLYMERIZABLE MONOMER
  申请人：Shimono Katsuhiro

  公开号：US20110174179A1

  公开（公告）日：2011-07-21

  There is provided a lithographic printing plate precursor that enables image recording using a laser and that provides an excellent scumming resistance and an excellent developability while maintaining a satisfactory printing durability. Also provided are a platemaking method, and a novel polymerizable monomer. A lithographic printing plate precursor has a support, and an image recording layer disposed thereon and containing a radical polymerization initiator and a polymerizable monomer that has a sulfonamide group and at least two ethylenically unsaturated groups; a lithographic printing plate platemaking method uses this lithographic printing plate precursor; and a polymerizable monomer has a sulfonamide group and at least two ethylenically unsaturated groups.
• RESIN COMPOSITION FOR LASER ENGRAVING, RELIEF PRINTING PLATE PRECURSOR FOR LASER ENGRAVING AND PROCESS FOR PRODUCING SAME, AND PROCESS FOR MAKING RELIEF PRINTING PLATE
  申请人：KAWASHIMA Takashi

  公开号：US20120146264A1

  公开（公告）日：2012-06-14

  A resin composition for laser engraving is provided that includes a low molecular weight compound containing at least one type of polymerizable group selected from the group consisting of an ethylenically unsaturated group, an epoxy group, an oxetanyl group, a hydrolyzable silyl group, and a silanol group and further containing a sulfonamide group, a low molecular weight compound containing a residue selected from the group consisting of a maleimide group, a succinimide group, and a phthalimide group, or a polymer compound containing a constituent unit derived from a compound containing a maleimide group or a constituent unit containing a sulfonamide group.
• SULFANYLAMIDE DERIVATIVES, USES THEREOF AND COMPOSITIONS COMPRISING THEM
  申请人：Bialer Meir

  公开号：US20120264827A1

  公开（公告）日：2012-10-18

  The present invention concerns a family of sulfanilamide derivatives of formula (I) as anticonvulsant agents, where R is selected from optionally substituted C 4 -C 9 alkyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 6 -C 10 alkylenearyl and optionally substituted C 5 -C 10 heteroaryl; R 2 is selected from —H and optionally substituted C 1 -C 6 alkyl; each of R 3 and R 4 , independently of each other, is selected from —H, optionally substituted C 1 -C 6 alkyl, optionally substituted C 6 -C 10 aryl and optionally substituted C 5 -C 10 heteroaryl; n is 0, 1, 2, 3 or 4. The derivatives have been prepared and their anticonvulsant profile was evaluated for the control of epileptic seizures.
• US9032876B2
  申请人：——

  公开号：US9032876B2

  公开（公告）日：2015-05-19