N,N'-bis(2-nitrophenyl)-1,2-ethanediamine | 5431-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-bis(2-nitrophenyl)-1,2-ethanediamine
• 英文别名: N,N’-bis(2-nitrophenyl)-1,2-ethanediamine；N,N’‑bis(2‑nitrophenyl)‑1,2‑ethanediamine；2-nitro-N-(2-(2-nitrophenylamino)propyl)benzenamine；N,N'-bis-(2-nitro-phenyl)-ethylenediamine；N,N'-Bis-(2-nitro-phenyl)-aethylendiamin；n,n'-Bis(2-nitrophenyl)ethane-1,2-diamine
• CAS: 5431-37-8
• 化学式: C₁₄H₁₄N₄O₄
• 分子量: 302.29
• InChiKey: KHMCOMFGTSIZPT-UHFFFAOYSA-N

物化性质

• 熔点：
  188 °C(Solv: benzene (71-43-2))
• 沸点：
  550.8±45.0 °C(Predicted)
• 密度：
  1.419±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2921590090

反应信息

• 作为反应物：
  描述：

  N,N'-bis(2-nitrophenyl)-1,2-ethanediamine 在 氯化铵 、 锌 作用下， 以 乙醇 、 水 为溶剂， 反应 3.0h， 生成 1.2-bis-(salicylideneaminophenylamine)-ethane
  参考文献：
  名称：

  Salicylimine-based fluorescent chemosensor for magnesium ions in aqueous solution

  摘要：

  A new fluorescent schiff base chemosensor (H2L) was prepared for the sensitive and selective sensing of Mg2+ ions based on multiple mechanisms. H2L is a weak fluorescent (f = 0.031) due to PET process and C=N isomerization. Upon addition of Mg2+, the complex [MgL] was formed and a remarkable fluorescence enhancement (f = 0.182) was produced. H2L had no such significant effect on the fluorescence in the presence of metal ions, such as Na+, Ag+, K+, Ca2+, Mg2+, Hg2+, Mn2+, Co2+, Ni-2(+), Cu2+, Zn2+, Cd2+, Pb2+, Cr-3(+), Fe3+, and In3+. The satisfactory linear relationship was observed between the added concentrations of Mg2+ and the fluorescence intensity of H2L. The detection limit was 3.04 x 10(-9) M with a rapid response time. Chemical inputs of Mg2+ and Fe3+ ions satisfy the conditions of INHIBIT molecular logic gate.

  DOI：

  10.1016/j.ica.2020.120021
• 作为产物：
  描述：

  溴苯 生成 N,N'-bis(2-nitrophenyl)-1,2-ethanediamine
  参考文献：
  名称：

  Jedlicka, Journal fur praktische Chemie (Leipzig 1954), 1893, vol. <2> 48, p. 196

  摘要：

  DOI：

文献信息

• 1,4–Diarylpiperazines and analogs as anti-tubercular agents: Synthesis and biological evaluation
  作者：D. Forge、D. Cappoen、J. Laurent、D. Stanicki、A. Mayence、T.L. Huang、L. Verschaeve、K. Huygen、J.J. Vanden Eynde

  DOI：10.1016/j.ejmech.2011.12.035

  日期：2012.3

  bacillary persistence and human immunodeficiency virus (HIV) co-infection hamper current drug treatment to completely cure the infection, generating a constant demand for novel drug candidates to tackle these problems. A small library of novel heterocyclic compounds was screened in a rapid luminometric in vitro assay against the laboratory M.tb. strain H37Rv. A group of amidines was found to have the highest

  尽管现代化学疗法在抗击结核病方面取得了进展，但致病菌结核分枝杆菌（M.tb.）仍未根除。细菌对抗分枝杆菌药的耐药性，细菌持续性和人类免疫缺陷病毒（HIV）共同感染阻碍了目前的药物治疗以完全治愈感染，从而产生了不断寻求新的候选药物来解决这些问题的需求。 在针对实验室M.tb的快速光度体外测定中筛选了一个小的新型杂环化合物文库。H37Rv株。发现一组of具有最高的效力，并进一步评估了其对C3A肝细胞的急性毒性。接下来，评估了最有前途的化合物对多药耐药临床分离株的活性。还测试了idine的组杀死细胞内M.tb的能力。驻留在小鼠J774A.1巨噬细胞中。最后，我们报告了化合物的结构差异与其抗分枝杆菌活性之间的相关性。
• Synthesis of Selected Novel Covalently Linked Flavoquinolones
  作者：Ram Singh、Geetanjali

  DOI：10.1055/s-2005-870019

  日期：——

  The synthesis of novel covalently linked flavoquino­lones via amide bond is described using mixed anhydride method and their spectroscopic studies have been done by UV/Vis and 1H NMR spectroscopic data.

  描述了通过混合酸酐法合成新型共价连接的黄酮喹诺酮类化合物，并通过紫外/可见光谱和1H核磁共振光谱数据进行了其光谱学研究。
• Syntheses and reactivity of bisflavins. Oxidation of N-benzyl-1,4-dihydronicotinamide by flavins in aqueous solution
  作者：Yumihiko Yano、Eiichi Ohya

  DOI：10.1039/p29840001227

  日期：——

  Several bisflavins linked at the 10,10′-positions of isoalloxazine rings have been synthesized. The kinetics of the oxidation of N-benzyl-1,4-dihydronicotinamide in aqueous solution have been examined. It has been found that each flavin of a bisflavin is considerably influenced by another intramolecular flavin moiety due to the formation of a charge-transfer complex between intramolecularly reduced

  已经合成了在异四恶嗪环的10,10'-位连接的几个双黄素。已经研究了N-苄基-1，4-二氢烟酰胺在水溶液中的氧化动力学。已经发现，由于在分子内还原的和氧化的黄素之间形成了电荷转移复合物，因此双黄素的每个黄素都受到另一种分子内的黄素部分的显着影响。复合物的形成取决于构象。
• UNUSUAL KINETIC BEHAVIOR OF BIS-FLAVIN FOR<i>N</i>-BENZYL-1,4-DIHYDRONICOTINAMIDE (BNAH) REDUCTION IN AN AQUEOUS SOLUTION
  作者：Yumihiko Yano、Eiichi Ohya

  DOI：10.1246/cl.1983.1281

  日期：1983.8.5

  Several bis-flavins linked at 10,10′-positions of isoalloxazine rings were synthesized. The reactivity of each flavin of a bis-flavin was found to be considerably influenced by another intramolecular flavin moiety, depending on the conformation of the bis-flavin.

  我们合成了几种连接在异咯嗪环 10,10′ 位上的双黄素。研究发现，双黄素中每个黄素的反应活性都会受到分子内另一个黄素分子的很大影响，这取决于双黄素的构象。
• Graphene-oxide/schiff base N2O4 ligand-palladium: A new catalyst for the synthesis of furan derivatives
  作者：Samira Noori、Ramin Ghorbani-Vaghei、Reza Azadbakht、Zahra Karamshahi、Mostafa Koolivand

  DOI：10.1016/j.molstruc.2021.131849

  日期：2022.2

  The findings revealed that GO/H2L-Pd could catalyze synthesis of furan derivatives in one-pot three-component condensation reaction by different aromatic aldehydes, arylamine and acetylenedicarboxylate. The major advantages of this study are the green and mild procedure, easy reaction work-up, short reaction time, high yields, and reusability of the catalyst.

  在本文中，我们旨在合成 GO/H 2 L-Pd 纳米复合材料（氧化石墨烯/席夫碱 N 2 O 4配体-钯）作为一种新型多相催化剂。应用不同的分析技术来分析催化剂的化学组成和结构。研究结果表明，GO/H 2 L-Pd 可以催化不同芳香醛、芳胺和乙炔二羧酸一锅三组分缩合反应合成呋喃衍生物。本研究的主要优点是绿色、温和、反应后处理容易、反应时间短、收率高、催化剂可重复使用。