N,N-Methylen-bis-propionamid | 13025-15-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-Methylen-bis-propionamid
• 英文别名: bis-propionylamino-methane；Bis-propionylamino-methan；methylene-bis-propionamide；N-methylene bispropionamide；N-[(propanoylamino)methyl]propanamide
• CAS: 13025-15-5
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: NGXAWGOVQDFBPW-UHFFFAOYSA-N

物化性质

• 熔点：
  201 °C
• 沸点：
  421.2±28.0 °C(Predicted)
• 密度：
  1.014±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 N,N-Methylen-bis-propionamid
  参考文献：
  名称：

  Einhorn; Hamburger, Justus Liebigs Annalen der Chemie, 1908, vol. 361, p. 126

  摘要：

  DOI：

文献信息

• NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF
  申请人：YEDA RESEARCH AND DEVELOPMENT CO., LTD.

  公开号：US20150284417A1

  公开（公告）日：2015-10-08

  The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to novel uses of certain pyridine Ruthenium complexes.

  本发明涉及新型的铑配合物和相关硼氢化物配合物，以及它们在以下方面的应用：(1)将酰胺(包括聚酰胺)加氢制备醇和胺；(2)用胺从醇中制备酰胺(包括通过二元醇和二胺反应或氨基醇的聚合制备聚酰胺(例如聚肽))；(3)将酯加氢制备醇(包括环状酯(内酯)，环状二酯(内二酯)或聚酯的加氢)；(4)将有机碳酸酯(包括聚碳酸酯)加氢制备醇和碳酸酯酰胺(包括聚碳酸酯酰胺)或脲衍生物制备醇和胺；(5)将醇脱氢耦合成酯；(6)将二级醇加氢制备酮；(7)酯胺化(从酯和胺合成酰胺)；(8)使用酯酰化醇；(9)将醇与水耦合形成羧酸；以及(10)将β-氨基醇脱氢形成吡嗪。本发明还涉及某些吡啶铑配合物的新型用途。
• A Reaction of Formaldehyde with Nitriles
  作者：M. A. Gradsten、M. W. Pollock

  DOI：10.1021/ja01189a072

  日期：1948.9
• Fernandez, A. Herrera; Alvarez, R. Martinez; Abajo, T. Morales, Synthesis, 1996, # 11, p. 1299 - 1301
  作者：Fernandez, A. Herrera、Alvarez, R. Martinez、Abajo, T. Morales

  DOI：——

  日期：——
• An Improved Synthesis of Symmetrical N,N′-Alkylidene-bis-amides
  作者：Everett R. GILBERT

  DOI：10.1055/s-1972-21820

  日期：——
• An efficient, green and scale-up synthesis of amides from esters and amines catalyzed by Ru-MACHO catalyst under mild conditions
  作者：Qian Han、Xingquan Xiong、Sizhong Li

  DOI：10.1016/j.catcom.2014.08.036

  日期：2015.1

  An efficient, green and scale-up synthesis of amides from esters and amines has been developed using Ru-MACHO as a readily available catalyst. A diverse range of amides were obtained in moderate to excellent yields (55-98%). Furthermore, when the scale of the amidation reaction was increased to 240.0 mmol, the desired amide still could be obtained in high yield (48.2 g of N-benzylbenzamide, 95%). (C) 2014 Elsevier B.V. All rights reserved.