5-sulfamoyl-N-(tetrahydrofurfuryl)anthranilic acid | 4818-84-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-sulfamoyl-N-(tetrahydrofurfuryl)anthranilic acid
• 英文别名: 5-sulfamoyl-2-tetrahydrofurfurylamino-benzoic acid；5-Sulfamoyl-N--anthranilsaeure；2-(Oxolan-2-ylmethylamino)-5-sulfamoylbenzoic acid
• CAS: 4818-84-2
• 化学式: C₁₂H₁₆N₂O₅S
• 分子量: 300.335
• InChiKey: UIPGOVRYBLKCDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  呋塞米 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以100%的产率得到5-sulfamoyl-N-(tetrahydrofurfuryl)anthranilic acid
  参考文献：
  名称：

  Pd/C–Et3N-mediated catalytic hydrodechlorination of aromatic chlorides under mild conditions

  摘要：

  A mild and efficient one-pot procedure for the hydrodechlorination of aromatic chlorides using a Pd/C-Et3N system was developed. A variety of aromatic chlorides could be dechlorinated at room temperature and under ambient hydrogen pressure. Et3N activates the catalysis and is likely to work as a single electron donor in this system. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.05.025

文献信息

• Pd/C–Et3N-mediated catalytic hydrodechlorination of aromatic chlorides under mild conditions
  作者：Yasunari Monguchi、Akira Kume、Kazuyuki Hattori、Tomohiro Maegawa、Hironao Sajiki

  DOI：10.1016/j.tet.2006.05.025

  日期：2006.8

  A mild and efficient one-pot procedure for the hydrodechlorination of aromatic chlorides using a Pd/C-Et3N system was developed. A variety of aromatic chlorides could be dechlorinated at room temperature and under ambient hydrogen pressure. Et3N activates the catalysis and is likely to work as a single electron donor in this system. (c) 2006 Elsevier Ltd. All rights reserved.