A branched organosilicon compound is provided which has the general formula (R1)3Si-X-NR2-X1 -NR22- In the formula: each R1 is selected from R and -OSi(R4)3, with the proviso that at least one R1 is -OSi(R4)3; each R4 is selected from R, -OSi(R5)3, and -[OSiR2]mOSiR3; each R1 is selected from R, -OSi(R6)3, and -[OSiR2]mOSiR3; each R6 is selected from R and -[OSiR2]mOSiR3; with the proviso that at least one of R4, R1 and R6 is -[OSiR2]mOSiR3; 0
提供了具有通式(R1)3Si-X-NR2-X1-N
R22-的分支
有机硅化合物。在该式中:每个R1从R和-OSi(R4)3中选择,但至少有一个R1是-OSi(R4)3;每个R4从R、-OSi(R5)3和-[OSiR2]mOSiR3中选择;每个R1从R、-OSi(R6)3和-[OSiR2]mOSiR3中选择;每个R6从R和-[OSiR2]mOSiR3中选择;但至少有一个R4、R1和R6是-[OSiR2]mOSiR3;0
有机硅化合物的组合物。
GEL COMPOSITIONS OF OXYMETAZOLINE AND METHODS OF USE
申请人:Shanler Stuart D.
公开号:US20130079379A1
公开(公告)日:2013-03-28
Embodiments relating to gels comprising imidazoline alpha agonists, such as, without limitation, oxymetazoline or a pharmaceutically acceptable salt thereof, and methods for treating diseases, such as, without limitation, rosacea, including, for example, erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, ocular rosacea or combinations thereof; and symptoms associated with rosacea, including, for example, papules, pustules, phymas (skin thickening), telangiectasias or erythema or redness associated with rosacea, other skin erythemas, telangiectasias, purpura or the like, and other manifestations associated therewith or combinations thereof using such gels are described herein.
本文描述了涵盖
咪唑啉α激动剂的凝胶实施例,例如,但不限于
甲醛唑啉或其药学上可接受的盐,并且描述了用这样的凝胶治疗疾病的方法,例如,但不限于酒渣鼻,包括红斑毛细血管扩张型酒渣鼻、丘疹脓疱型酒渣鼻、皮肤增厚型酒渣鼻、眼部酒渣鼻或其组合;以及与酒渣鼻相关的症状,例如丘疹、脓疱、酒渣鼻(皮肤增厚)、毛细血管扩张或与酒渣鼻相关的红斑或红色症状,其他皮肤红斑、毛细血管扩张、紫斑或类似症状以及与之相关的其他表现或其组合。