4,4''-dichloro-2,2':6',2''-terpyridin-4'(1'H)-one | 1042910-46-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,4''-dichloro-2,2':6',2''-terpyridin-4'(1'H)-one
• 英文别名: 4,4''-dichloro-1'H-[2,2';6',2'']terpyridin-4'-one；4,4''-dichlor-1'H-[2,2';6',2'']terpyridin-4'-on；2,6-bis(4-chloropyridin-2-yl)-1H-pyridin-4-one
• CAS: 1042910-46-2
• 化学式: C₁₅H₉Cl₂N₃O
• 分子量: 318.162
• InChiKey: VAVWNMRTAFGXDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4''-dichloro-2,2':6',2''-terpyridin-4'(1'H)-one 在 五氯化磷 、 三氯氧磷 作用下， 反应 4.0h， 以77%的产率得到4,4',4''-trichloro-2,2':6',2''-terpyridine
  参考文献：
  名称：

  Synthesis of substituted terpyridine ligands for use in protein purification

  摘要：

  A number of 4,4 ''-disubstituted terpyridines bearing a 4'-thioethanamine linker, and regioisomers thereof, have been synthesised from 4-substituted picolinates. The substituted terpyridines were immobilised onto epoxy-activated Sepharose (TM) FF gel, creating functionalised solid supports for the fractionation of proteins-including antibodies-by mixed mode affinity chromatography. The metal chelating properties of the immobilised ligand render the stationary phase also amenable for use in immobilised metal-ion affinity chromatography (IMAC), and have been demonstrated with the purification of suitably tagged green fluorescent protein (GFP). (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2014.09.074
• 作为产物：
  描述：

  1,5-Bis(4-chloropyrid-2-yl)-pentane-1,3,5-trione 在 ammonium acetate 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以3 g的产率得到4,4''-dichloro-2,2':6',2''-terpyridin-4'(1'H)-one
  参考文献：
  名称：

  Synthesis of substituted terpyridine ligands for use in protein purification

  摘要：

  A number of 4,4 ''-disubstituted terpyridines bearing a 4'-thioethanamine linker, and regioisomers thereof, have been synthesised from 4-substituted picolinates. The substituted terpyridines were immobilised onto epoxy-activated Sepharose (TM) FF gel, creating functionalised solid supports for the fractionation of proteins-including antibodies-by mixed mode affinity chromatography. The metal chelating properties of the immobilised ligand render the stationary phase also amenable for use in immobilised metal-ion affinity chromatography (IMAC), and have been demonstrated with the purification of suitably tagged green fluorescent protein (GFP). (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2014.09.074

文献信息

• Use of metal complex compounds as catalysts for oxidation using molecular oxygen or air
  申请人：Wieprecht Torsten

  公开号：US20060019853A1

  公开（公告）日：2006-01-26

  Use, as a catalyst for oxidation reactions using molecular oxygen and/or air, of at least one metal complex compound of formula (1) wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, Y is a counter-ion, q=z/(charge of Y), and L is a ligand of formula (2) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently of the others hydrogen; unsubstituted or substituted C 1 -C 18 alkyl or aryl; cyano; halogen; nitro; —COOR 12 or —SO 3 R 12 wherein R 12 is in each case hydrogen, a cation or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —SR 13 , —SO 2 R 13 or —OR 13 wherein R 13 is in each case hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —NR 14 R 15 ; —(C 1 -C 6 alkylene)-NR 14 R 15 ; —N (+) R 14 R 15 R 16 ; —(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16 ; —N(R 13 )—(C 1 -C 6 alkylene)-NR 14 R 15 ; —N[(C 1 -C 6 alkylene)-NR 14 R 15 ] 2 ; —N(R 13 )—(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16 ; —N[(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16]2 ; —N(R 13 )—N—R 14 R 15 or —N(R 13 )N″R 14 R 15 R 16 , wherein R 13 is as defined above and R 14 , R 15 and R 16 are each independently of the other(s) hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl, or R 14 and R 15 , together with the nitrogen atom linking them, form an unsubstituted or substituted 5-, 6- or 7-membered ring which may contain further hetero atoms. [L n Me m X p ] z Y q (1)

  使用至少一种具有以下式（1）的金属配合物化合物作为氧化反应的催化剂，其中Me为锰、钛、铁、钴、镍或铜，X为配位或桥联基团，n和m分别独立地为1至8之间的整数，p为0至32之间的整数，z为金属配合物的电荷，Y为对离子，q=z/(Y的电荷)，L为具有以下式（2）的配体，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11各自独立地为氢；未取代或取代的C1-C18烷基或芳基；氰基；卤素；硝基；—COOR12或—SO3R12，其中R12在每种情况下为氢、阳离子或未取代或取代的C1-C18烷基或芳基；—SR13、—SO2R13或—OR13，其中R13在每种情况下为氢或未取代或取代的C1-C18烷基或芳基；—NR14R15；—(C1-C6烷基)-NR14R15；—N(+)R14R15R16；—(C1-C6烷基)-N(+)R14R15R16；—N(R13)—(C1-C6烷基)-NR14R15；—N[(C1-C6烷基)-NR14R15]2；—N(R13)—(C1-C6烷基)-N(+)R14R15R16；—N[(C1-C6烷基)-N(+)R14R15R16]2；—N(R13)—N—R14R15或—N(R13)N″R14R15R16，其中R13如上定义，R14、R15和R16各自独立地为氢或未取代或取代的C1-C18烷基或芳基，或R14和R15与连接它们的氮原子一起形成未取代或取代的5、6或7成员环，该环可能含有进一步的杂原子。[LnMemXp]zYq（1）
• A Supramolecular Strategy toward an Efficient and Selective Capture of Platinum(II) Complexes
  作者：Zhen Chen、Alan Kwun-Wa Chan、Victor Chun-Hei Wong、Vivian Wing-Wah Yam

  DOI：10.1021/jacs.9b04397

  日期：2019.7.17

  remains in how to realize the highly selective removal and recovery of a particular metal of interest, such as platinum. Here we experimentally demonstrate a two-dimensional (2D) supramolecular polymer that can serve as a host for the highly selective capture of anionic platinum(II) (PtII) species including its metal-organic complexes and water-soluble ions. This host polymer possesses a 2D honeycomb-like

  从废水中回收重金属和贵金属在经济和环境方面都具有吸引力。然而，如何实现对特定目标金属（例如铂）的高选择性去除和回收仍然存在挑战。在这里，我们通过实验证明了一种二维 (2D) 超分子聚合物，它可以作为高度选择性捕获阴离子铂 (II) (PtII) 物种的宿主，包括其金属有机配合物和水溶性离子。这种主体聚合物具有由阳离子炔基铂 (II) 三联吡啶二聚体非共价桥接的二维蜂窝状纳米结构。阴离子 PtII 客体很容易通过静电和特定的 PtII…PtII 相互作用与内腔的二聚体 PtII 结构单元结合。
• Use of metal complex compounds as oxidation catalysts
  申请人：Schlingloff Gunther

  公开号：US20060100123A1

  公开（公告）日：2006-05-11

  Use of metal complex compounds of formula (1) [L n Mc m X p ] z Y q wherein Mc is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, Y is a counter-ion, q=z/(charge Y), and L is a ligand of formula (2) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently of the others hydrogen: unsubstituted or substituted C 1 -C 18 alkyl or aryl; cyano; halogen; nitro; —COOR 12 or —SO 3 R 12 wherein R 12 is in each case hydrogen, a cation or unsubstituted or substituted C 1 -C 18 alkyl or aryl: —SR 13 , —SO 12 R 13 or —OR 13 wherein R 13 is in each case hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —NR 14 R 15 ; —(C 1 -C 6 alkylene)-NR 14 R 15 ; —N o R 14 R 15 R 16 ; —(C 1 -C 6 alkylene)-N o R 14 R 15 R 16 ; —N(R) 15 )—(C 1 -C 6 alkylene)-NR 1 R 15 ; —N[(C 1 -C 6 alkylene)-NR 14 R 15 ] 2 ; —N(R 13 )—(C 1 -C 6 alkylene)-N o R 14 R 15 R 16 , —N[C 1 -C 6 alkylene)-N o R 14 R 15 R 16 ] 2 ; —N(R 13 )—N—R 14 R 15 or —N(R 13 )—N o R 14 R 15 R 16: wherein R 13 is as defined above and R 14 , R 15 and R 16 are each independently of the other(s) hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl, or R 14 and R 15 together with the nitrogen atom bonding them form an unsubstituted or substituted 5-, 6- or 7-membered ring which may optionally contain further heterotatoms; with the proviso that (i) at least one of the substituents R 1 —R 11 contains a quaternized atom which is not directly bonded to one of the three pyridine A, B or C and that (ii) Y is neither I′ nor Cl′ in the case that Me is Mn(II), R 1 —R 5 and R 7 —R 11 are hydrogen and R 6 is formula (III) as catalysts for oxidation reactions, and the novel metal complex compounds of formula (1), the novel ligands of formula (2) and their starting materials.

  使用式（1）的金属配合物化合物 [LnMcmXp]zYq，其中Mc是锰、钛、铁、钴、镍或铜，X是配位或桥接基团，n和m分别独立地为1至8的整数，p为0至32的整数，z是金属配合物的电荷，Y是反离子，q=z/（反离子Y的电荷），L是式（2）的配体，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11各自独立地是氢、未取代或取代的C1-C18烷基或芳基、氰、卤素、硝基、-COOR12或-SO3R12，其中R12在每种情况下是氢、阳离子或未取代或取代的C1-C18烷基或芳基：-SR13、-SO12R13或-OR13，其中R13在每种情况下是氢或未取代或取代的C1-C18烷基或芳基；-NR14R15；-（C1-C6烷基）-NR14R15；-NoR14R15R16；-（C1-C6烷基）-NoR14R15R16；-N（R）15）-（C1-C6烷基）-NR1R15；-N [（C1-C6烷基）-NR14R15]2；-N（R13）-（C1-C6烷基）-NoR14R15R16，-N [（C1-C6烷基）-NoR14R15R16]2；-N（R13）-N-R14R15或-N（R13）-NoR14R15R16：其中R13如上所定义，R14、R15和R16各自独立地是氢或未取代或取代的C1-C18烷基或芳基，或者R14和R15连同它们之间的氮原子形成未取代或取代的5、6或7元环，该环可以选择性地含有进一步的杂原子；条件是（i）至少一个取代基R1-R11含有一个季铵化的原子，该原子没有直接与三个吡啶A、B或C之一相键合，并且（ii）在Me为Mn（II），R1-R5和R7-R11为氢，R6为式（III）的情况下，Y既不是I'也不是Cl'，作为氧化反应的催化剂，以及式（1）的新型金属配合物化合物、式（2）的新型配体及其起始材料。
• USE OF METAL COMPLEX COMPOUNDS AS OXIDATION CATALYSTS
  申请人：GERET Laurence

  公开号：US20060247144A1

  公开（公告）日：2006-11-02

  An automatic dishwasher detergent formulation comprising:—a) a metal complex compound of formula (1) [L n Me m X p ] z Y q (1), wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, Y is a counter-ion, q=z/(charge Y), and L is a ligand of formula (2) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently of the others hydrogen; unsubstituted or substituted C 1 -C 18 alkyl or aryl; cyano; halogen; nitro; —COOR 12 or —SO 3 R 12 wherein R 12 is in each case hydrogen, a cation or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —SR 13 , —SO 2 R 13 or —OR 13 wherein R 13 is in each case hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —NR 14 R 15 ; —(C 1 -C 6 alkylene)-NR 14 R 15 ; —N ⊕ R 14 R 15 R 16 ; —(C 1 -C 6 alkylene)-N ⊕ R 14 R 15 R 16 ; —N(R 13 )—(C 1 -C 6 alkylene)-NR 14 R 15 ; —N[(C 1 -C 6 alkylene)-NR 14 R 15 ] 2 ; —N(R 13 )—(C 1 -C 6 alkylene)-N ⊕ R 14 R 15 R 16 , —N[(C 1 -C 6 alkylene)-N ⊕ R 14 R 15 R 16 ] 2 ; —N(R 13 )—N—R 14 R 15 or —N(R 13 )—N ⊕ R 14 R 15 R 16 , wherein R 13 is as defined above and R 14 , R 15 and R 16 are each independently of the other(s) hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl, or R 14 and R 15 together with the nitrogen atom bonding them form an unsubstituted or substituted 5-, 6- or 7-membered ring which may optionally contain further heteroatoms; with the proviso that (i) at least one of the substituents R 1 —R 11 contains a quaternized nitrogen atom which is not directly bonded to one of the three pyridine rings A, B or C and that (ii) Y is neither I − nor Cl − in the case that Me is Mn(II), R 1 —R 5 and R 7 —R 11 are hydrogen and R 6 is as catalysts for oxidation reactions; and b) a sulphonated polymer

  一种自动洗碗机洗涤剂配方，包括：- 公式（1）中的金属配合物化合物[LnMemXp]zYq（1），其中Me为锰、钛、铁、钴、镍或铜，X为配位或桥接基团，n和m分别独立地为1至8的整数，p为0至32的整数，z为金属配合物的电荷，Y为反离子，q = z /（Y电荷），L为公式（2）中的配体其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10和R11各自独立地为氢; 未取代或取代的C1-C18烷基或芳基; 氰基; 卤素; 硝基; -COOR12或-SO3R12，其中R12在每种情况下均为氢，阳离子或未取代或取代的C1-C18烷基或芳基; -SR13，-SO2R13或-OR13，其中R13在每种情况下均为氢或未取代或取代的C1-C18烷基或芳基; -NR14R15; -(C1-C6烷基)-NR14R15; -N⊕R14R15R16; -(C1-C6烷基)-N⊕R14R15R16; -N（R13） -（C1-C6烷基）-NR14R15; -N [（C1-C6烷基）-NR14R15]2; -N（R13） -（C1-C6烷基）-N⊕R14R15R16，-N [（C1-C6烷基）-N⊕R14R15R16]2; -N（R13） -N-R14R15或-N（R13） -N⊕R14R15R16，其中R13如上定义，而R14、R15和R16各自独立地为氢或未取代或取代的C1-C18烷基或芳基，或R14和R15与它们连接的氮原子形成未取代或取代的5、6或7元环，该环可以选择包含进一步的杂原子; 前提是（i）至少一个取代基R1-R11包含一个季铵氮原子，该氮原子未直接与三个吡啶环A、B或C之一结合，且（ii）在Me为Mn（II），R1-R5和R7-R11为氢，R6为氧化反应的催化剂的情况下，Y既不是I-也不是Cl-; 和b）磺化聚合物。
• Use of metal complex compounds comprising pyridine pyrimidine or s-triazine derived ligands as catalysts for oxidations with organic peroxy acids and/or precursors of organic peroxy acids and h202
  申请人：Wieprecht Torsten

  公开号：US20090189119A1

  公开（公告）日：2009-07-30

  The invention accordingly relates to the use as catalysts of at least one metal complex of formula (1) [L n Me m X p ] z Y q (1), wherein all substituents have the meanings as defined in the claims for oxidation reactions with organic peroxy acids and/or precursors of organic peroxy acid and H 2 O 2 , as well as to novel detergent compositions.

  该发明涉及使用至少一个化合物的金属配合物作为催化剂，该化合物的化学式为（1）[LnMemXp]zYq(1)，其中所有取代基的含义如权利要求所定义，用于有机过氧酸和/或有机过氧酸前体以及H2O2的氧化反应，以及新型洗涤剂组合物。