Dihydropaucin | 55760-27-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Dihydropaucin
• 英文别名: N-(4-Aminobutyl)-3-(3,4-dihydroxyphenyl)propanamide
• CAS: 55760-27-5
• 化学式: C₁₃H₂₀N₂O₃
• 分子量: 252.313
• InChiKey: YENOAGRCWVRUBZ-UHFFFAOYSA-N

物化性质

• 沸点：
  547.2±50.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  95.6
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-dihydroxy-trans-cinnamic acid-(4-amino-butylamide); dihydrochloride 在 platinum(IV) oxide 盐酸 、 氢气 作用下， 生成 Dihydropaucin
  参考文献：
  名称：

  Die Struktur des Paucins

  摘要：

  DOI：

  10.1007/bf00907534

文献信息

• Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus
  作者：Boon-ek Yingyongnarongkul、Nuttapon Apiratikul、Nuntana Aroonrerk、Apichart Suksamrarn

  DOI：10.1016/j.bmcl.2006.08.062

  日期：2006.11

  A library of hydroxycinnamic acid amides (HCAAs) and analogues were synthesized using solid-phase synthesis technique. These compounds were screened for antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Dihydrocaffeoyl analogues showed activity against VRSA which were better than the reference drugs, vancomycin and oxacillin. These compounds also exhibited antibacterial activity against MRSA, which were more potent than oxacillin. (c) 2006 Elsevier Ltd. All rights reserved.
• Die Struktur des Paucins
  作者：Alfred Hollerbach、Gerhard Spiteller

  DOI：10.1007/bf00907534

  日期：——