uric acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: uric acid
• 英文别名: 9H-purine-2,6,8-trione
• 化学式: C₅H₂N₄O₃
• 分子量: 166.096
• InChiKey: QBWXIMRDQPYHAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  uric acid 在 维生素 C 作用下， 以 aq. phosphate buffer 为溶剂， 生成 尿酸
  参考文献：
  名称：

  十六烷基三甲基溴化铵-聚苯胺/活性炭复合物在高浓度抗坏血酸存在下同时测定多巴胺和尿酸

  摘要：

  我们描述了一种由十六烷基三甲基溴化铵（CTAB）官能化的聚苯胺（PANI）和活性炭（CTAB-PANI / AC）组成的简单，低成本且可大量生产的复合物，用于同时测定多巴胺（DA）和尿酸。

  DOI：

  10.1039/c6ra18740d
• 作为产物：
  描述：

  尿酸 在 poly N-acetyl-L-methionine film on glassy carbon electrode 作用下， 以 aq. phosphate buffer 为溶剂， 生成 uric acid
  参考文献：
  名称：

  基于新型聚N-乙酰基-1-蛋氨酸（poly-NALM）薄膜的高选择性同时测定抗坏血酸，尿酸和亚硝酸盐†

  摘要：

  本文证明了N-乙酰基-L的简便制备-通过电聚合技术在玻璃碳电极（GCE）上生成蛋氨酸（NALM）聚合物薄膜。原子力显微镜（AFM），X射线光电子能谱（XPS），扫描电子显微镜（SEM）和电化学技术（例如循环伏安法（CV）和微分脉冲伏安法（DPV））用于表征修饰电极。这种多聚NALM / GCE不仅对抗坏血酸（AA），尿酸（UA）和亚硝酸盐的氧化表现出强大的电催化活性，而且氧化电位也向着较弱的一侧转移，而且还增强了在生理pH值下的峰值电流响应（7.2）条件。进一步，裸露的GC电极上三种分析物的重叠阳极伏安峰在聚NALM / GC修饰电极上被很好地解析为它们的独立氧化峰，AA–UA和UA–亚硝酸盐的峰间距分别为160和590 mV，分别。在最佳实验条件下，AA，UA和亚硝酸盐的阳极峰值电流在10–1000μM，1–600μM和1–500μM浓度范围内线性增加，相关系数分别为0.990、0.996和0

  DOI：

  10.1039/c6ra18440e

文献信息

• METAL-ORGANIC FRAMEWORKS FOR ELECTROCHEMICAL DETECTION OF ANALYTES
  申请人：Trustees of Dartmouth College

  公开号：US20210262970A1

  公开（公告）日：2021-08-26

  In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer.

  在某些实施例中，本公开涉及通过将样品与包含金属-有机框架的电极相关联来检测样品中的分析物的方法。在关联后，评估电极的氧化还原性质。然后，通过将电极的氧化还原性质与分析物的存在或缺失相关联来检测样品中的分析物的存在或缺失。在某些实施例中，本公开涉及包括金属-有机框架和电极表面的电极。在本公开的特定实施例中，金属-有机框架与电极表面相关联。本公开的其他实施例涉及通过将金属-有机框架与电极表面相关联来制备本公开的电极的方法。在某些实施例中，本公开的方法还包括将金属-有机框架与聚合物混合的步骤。
• Conducting polyaniline-graphene oxide fibrous nanocomposites: preparation, characterization and simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid
  作者：P. Manivel、M. Dhakshnamoorthy、A. Balamurugan、N. Ponpandian、D. Mangalaraj、C. Viswanathan

  DOI：10.1039/c3ra42322k

  日期：——

  Polyaniline/graphene oxide (PANI-GO) fibrous nanocomposites have been prepared and the electrochemical catalytic activity towards the electro-oxidation of ascorbic acid (AA), Dopamine (DA) and Uric acid (UA) has been investigated. The nanocomposites were synthesized via an in situ chemical polymerization method. The morphology, composition, thermal and electrochemical properties of the resulting nanocomposites were characterized by scanning electron microscopy, X-ray diffraction, Raman spectroscopy, FT-IR spectroscopy, thermo gravimetric analysis and cyclic voltammetry. The catalytic behavior of PANI-GO nanocomposite modified glassy carbon electrode (GCE) towards AA, DA and UA has been investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV). The PANI-GO/GCE showed excellent catalytic activity towards electrochemical oxidation of AA, DA and UA compared to the bare GCE. The electrochemical oxidation signal of AA, DA and UA are well separated into three distinct peaks with peak potential separation of 343 mV, 145 mV and 488 mV between AA-DA, DA-UA and AA-UA respectively in CV studies and the corresponding peak potential separation in DPV mode are 320 mV, 230 mV and 550 mV. Under the optimized DPV experimental conditions, the peak current of AA, DA and UA give linear response over the range of 25–200 μM (R2 = 0.9955), 2–18 μM (R2 = 0.9932) and 2–18 μM (R2 = 0.9902) with detection limit of 20 μM, 0.5 μM and 0.2 μM at S/N = 3, respectively. The attractive features of PANI-GO provide potential applications in the simultaneous detection of AA, DA and UA. The excellent electrocatalytic behavior of PANI-GO may lead to new applications in electrochemical analysis.

  制备了聚苯胺/氧化石墨烯（PANI-GO）纤维状纳米复合材料，并研究了其对抗坏血酸（AA）、多巴胺（DA）和尿酸（UA）电氧化的电化学催化活性。纳米复合材料是通过原位化学聚合法合成的。通过扫描电子显微镜、X 射线衍射、拉曼光谱、傅立叶变换红外光谱、热重分析和循环伏安法对所得到的纳米复合材料的形态、组成、热和电化学特性进行了表征。通过循环伏安法（CV）和微分脉冲伏安法（DPV）研究了 PANI-GO 纳米复合材料修饰的玻璃碳电极（GCE）对 AA、DA 和 UA 的催化行为。与裸露的 GCE 相比，PANI-GO/GCE 对 AA、DA 和 UA 的电化学氧化表现出卓越的催化活性。在 CV 研究中，AA、DA 和 UA 的电化学氧化信号被很好地分离成三个不同的峰，AA-DA、DA-UA 和 AA-UA 的峰电位分离值分别为 343 mV、145 mV 和 488 mV；在 DPV 模式中，相应的峰电位分离值分别为 320 mV、230 mV 和 550 mV。在优化的 DPV 实验条件下，AA、DA 和 UA 的峰值电流在 25-200 μM （R2 = 0.9955）、2-18 μM （R2 = 0.9932）和 2-18 μM （R2 = 0.9902）范围内呈线性响应，在信噪比为 3 时，检测限分别为 20 μM、0.5 μM 和 0.2 μM。PANI-GO 的诱人特性为同时检测 AA、DA 和 UA 提供了潜在的应用前景。PANI-GO 卓越的电催化行为可能会在电化学分析中带来新的应用。
• Non-enzymatic simultaneous detection of <scp>l</scp>-glutamic acid and uric acid using mesoporous Co₃O₄ nanosheets
  作者：Mohammad Musarraf Hussain、Mohammed M. Rahman、Abdullah M. Asiri、Md. Rabiul Awual

  DOI：10.1039/c6ra12256f

  日期：——

  Co₃O₄ nanosheets were synthesized by wet chemical technique at low-temperature in alkaline phase.

  在碱性相中，利用湿化学技术在低温下合成了Co3O4纳米片。
• Identification of Fleeting Electrochemical Reaction Intermediates Using Desorption Electrospray Ionization Mass Spectrometry
  作者：Timothy A. Brown、Hao Chen、Richard N. Zare

  DOI：10.1021/jacs.5b03862

  日期：2015.6.17

  method for the mass spectrometric detection of fleeting reaction intermediates in electrochemical reactions utilizing a "waterwheel" working electrode setup. This setup takes inspiration from desorption electrospray ionization (DESI) mass spectrometry, where the sampling time is on the order of milliseconds, to sample directly from the surface of a working electrode for mass spectrometric analysis. We

  我们报告了一种使用“水车”工作电极设置对电化学反应中短暂反应中间体进行质谱检测的新方法。此设置的灵感来自解吸电喷雾电离 (DESI) 质谱法，其中采样时间为毫秒级，可直接从工作电极表面采样以进行质谱分析。我们提供的数据显示了尿酸电化学氧化的二亚胺中间体的形成，其在溶液中的寿命为 23 ms，以及为黄嘌呤电氧化形成类似二亚胺物种提供证据的数据，其具有以前没有观察到。
• α-Fe2O3 nanoflowers: synthesis, characterization, electrochemical sensing and photocatalytic property
  作者：R. Suresh、K. Giribabu、R. Manigandan、A. Vijayaraj、R. Prabu、A. Stephen、V. Narayanan

  DOI：10.1007/s13738-013-0335-0

  日期：2014.6

  Nanoflower structured α-Fe2O3 was synthesized by adding hexamine to an aqueous solution of ferrous sulphate followed by drying and annealing at 600 °C for 6 h. X-ray diffraction analysis, Fourier-transformed infrared spectroscopy, Raman and DRS UV–visible absorption spectroscopy showed the formation of α-Fe2O3 with good crystalline nature. Field emission-scanning electron microscopy investigation revealed that the α-Fe2O3 has flower-like morphology, which is composed of nanorods. Cyclic voltammetry and chronoamperometry were used to investigate their electrochemical sensing property towards uric acid (UA). α-Fe2O3 exhibited enhanced sensing behavior with respect to that of bare GCE. Additionally, the α-Fe2O3 nanoflowers exhibit better photocatalytic activity of up to 71.7 % against rhodamine B (RhB) in short time of 60 min under visible light irradiation. It is found that the smaller crystallite size and flower-like morphology play a vital role in allowing an interaction between α-Fe2O3 and UA or RhB dye which enhances both the electrochemical sensing and photocatalytic activity.

  通过将乌洛托品添加到硫酸亚铁水溶液中，然后在 600°C 下干燥和退火 6 小时，合成了纳米花结构的 α-Fe2O3。 X射线衍射分析、傅里叶变换红外光谱、拉曼光谱和DRS紫外可见吸收光谱表明形成了具有良好结晶性质的α-Fe2O3。场发射扫描电子显微镜研究表明，α-Fe2O3 具有花状形貌，由纳米棒组成。使用循环伏安法和计时电流法研究它们对尿酸（UA）的电化学传感特性。与裸 GCE 相比，α-Fe2O3 表现出增强的传感行为。此外，α-Fe2O3纳米花在可见光照射下在60分钟的短时间内对罗丹明B（RhB）表现出高达71.7%的光催化活性。研究发现，较小的晶粒尺寸和花状形态对于 α-Fe2O3 与 UA 或 RhB 染料之间的相互作用起着至关重要的作用，从而增强电化学传感和光催化活性。