dimethylamino-acetic acid hydrazide methohydroxide | 50857-66-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethylamino-acetic acid hydrazide methohydroxide
• 英文别名: Dimethylamino-essigsaeure-hydrazid-methohydroxyd；Trimethylammonio-essigsaeure-hydrazid-hydroxyd；Trimethylammonio-acethydrazid-hydroxyd；Betain-hydrazid；Hydrazidoacetyl-trimethyl-ammonium；Girard's-T-Reagenz；2-Hydrazinyl-N,N,N-trimethyl-2-oxoethan-1-aminium；(2-hydrazinyl-2-oxoethyl)-trimethylazanium
• CAS: 50857-66-4
• 化学式: C₅H₁₄N₃O
• 分子量: 132.186
• InChiKey: LFHMEPBADGDQAP-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  可的松 、 dimethylamino-acetic acid hydrazide methohydroxide 在 甲酸 作用下， 以 甲醇 、 水 为溶剂， 反应 0.03h， 生成
  参考文献：
  名称：

  CONDUCTING REACTIONS IN LEIDENFROST-LEVITATED DROPLETS

  摘要：

  该发明通常涉及在Leidenfrost悬浮的液滴中进行反应。

  公开号：

  US20170349547A1

文献信息

• Multivalent DNA recognition by self-assembled clusters: deciphering structural effects by fragments screening and evaluation as siRNA vectors
  作者：Eline Bartolami、Yannick Bessin、Nadir Bettache、Magali Gary-Bobo、Marcel Garcia、Pascal Dumy、Sébastien Ulrich

  DOI：10.1039/c5ob01404b

  日期：——

  Fragment self-assembly was used for producing clusters with a variety of scaffolds and ligands, and an effective siRNA vector was identified.

  片段自组装被用于生产具有多种支架和配体的簇，并成功识别了一种有效的siRNA载体。

• Establishment of a Charge Reversal Derivatization Strategy to Improve the Ionization Efficiency of Limaprost and Investigation of the Fragmentation Patterns of Limaprost Derivatives Via Exclusive Neutral Loss and Survival Yield Method
  作者：Dong Sun、Xiangjun Meng、Tianming Ren、John Paul Fawcett、Hualu Wang、Jingkai Gu

  DOI：10.1007/s13361-018-1924-z

  日期：2018.7.1

  improve the ionization efficiency of limaprost, an oral prostaglandin E1 (PGE1) synthetic analog, we investigated a charge reversal derivatization strategy in electrospray ionization mass spectrometry (ESI-MS). We established that the cholamine derivative exhibits much greater signal intensity in the positive-ion mode compared with limaprost in the negative ion mode. Collision-induced dissociation

  由于前列腺素及其合成类似物在体内的浓度极低，因此敏感性在前列腺素及其合成类似物的生物测定中通常是一个问题。。为提高口服前列腺素E1（PGE1）合成类似物利马前列素的电离效率，我们研究了电喷雾电离质谱（ESI-MS）中的电荷逆转衍生化策略。我们确定，与利马前列素在负离子模式下相比，胆碱衍生物在正离子模式下表现出更大的信号强度。碰撞诱导解离（CID）涉及排他性中性质量损失和正电荷迁移，以形成稳定的阳离子产物离子，在利马前列素残基而不是修饰基团上带有正电荷。这具有保持多反应监测（MRM）的效率和特异性并避免串扰的效果。其他利马前列素衍生物的CID碎裂模式使我们能够基于存活率法将不同的中性离去基团的解离趋势与内部能量分布尺度相关联。了解产生稳定的阳离子所需的能量将可能有助于选择合适的衍生化试剂，以分析各种脂质酸。 在新窗口中打开图像 图形概要 ᅟ
• In Situ Probing and Identification of Electrochemical Reaction Intermediates by Floating Electrolytic Electrospray Mass Spectrometry
  作者：Jianxiong Chen、Xiangyu Wang、Xi Cui、Yongyi Li、Yuqi Feng、Zhenwei Wei

  DOI：10.1002/anie.202219302

  日期：2023.3.13

  electrolytic electrospray ionization provided a general solution for the in situ monitoring and characterization of electrochemical reaction intermediates by mass spectrometry. Its successful application in discovery and identification of active nitrene intermediates during electrochemical processes proved this platform a powerful tool for reaction-mechanism studies in the future.

  浮动电解电喷雾电离为通过质谱法原位监测和表征电化学反应中间体提供了通用解决方案。它在电化学过程中发现和鉴定活性氮烯中间体的成功应用证明了该平台是未来反应机理研究的有力工具。
• A Redox Isomerization Strategy for Accessing Modular Azobenzene Photoswitches with Near Quantitative Bidirectional Photoconversion
  作者：Jie S. Zhu、Julio M. Larach、Robert J. Tombari、Phillip W. Gingrich、Stanley R. Bode、Jeremy R. Tuck、Hunter T. Warren、Jung-Ho Son、Whitney C. Duim、James C. Fettinger、Makhluf J. Haddadin、Dean J. Tantillo、Mark J. Kurth、David E. Olson

  DOI：10.1021/acs.orglett.9b03387

  日期：2019.11.1

  Photoswitches capable of accessing two geometric states are highly desirable, especially if their design is modular and incorporates a pharmacophore tethering site. We describe a redox isomerization strategy for synthesizing p-formylazobenzenes from p-nitrobenzyl alcohol. The resulting azo-aldehydes can be readily converted to photoswitchable compounds with excellent photophysical properties using simple hydrazide click chemistry. As a proof of principle, we synthesized a photoswitchable surfactant enabling the photocontrol of an emulsion with exceptionally high spatiotemporal precision.
• KIDWELL D. A.; ROSS M. M.; COLTON R. J., SECONDARY ION MASS SPECTROM. SIMS 5. PROC. 5 INT. CONF., WASHINGTON, DC.,+
  作者：KIDWELL D. A.、 ROSS M. M.、 COLTON R. J.

  DOI：——

  日期：——