1,3-dilinolenoyl-sn-glycerol | 98242-77-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1,3-dilinolenoyl-sn-glycerol
• 英文别名: glycerol-1,3-dilinoleneate；1,3-dilinolenin；glycerol-1,3-dilynolenate；Glycerin-1,3-dilinolenat；1.3-Dilinolenin；1,3-Dilinolenoylglycerol；[2-hydroxy-3-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]oxypropyl] (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• CAS: 98242-77-4
• 化学式: C₃₉H₆₄O₅
• 分子量: 612.934
• InChiKey: NSOPGAYUGBZWHL-YTWBPVBXSA-N

物化性质

• 沸点：
  675.9±55.0 °C(Predicted)
• 密度：
  0.9568 g/cm3
• 溶解度：
  氯仿：微溶；甲醇：微溶
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  11.6
• 重原子数：
  44
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3-dilinolenoyl-sn-glycerol 在 乙醇 、 钯 作用下， 生成 1,3-二硬脂酸甘油酯
  参考文献：
  名称：

  Daubert; Lutton, Journal of the American Chemical Society, 1947, vol. 69, p. 1450

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 1,3-dilinolenoyl-sn-glycerol
  参考文献：
  名称：

  Sarytschewa et al., Zhurnal Obshchei Khimii, 1959, vol. 29, p. 3583,3586; engl.Ausg.S.3544,3546

  摘要：

  DOI：

文献信息

• Site-Specific Deuteration of Polyunsaturated Alkenes
  作者：A. V. Smarun、M. Petković、M. S. Shchepinov、D. Vidović

  DOI：10.1021/acs.joc.7b02169

  日期：2017.12.15

  and expensive syntheses. In this report, we disclose a very efficient catalytic protocol for site-specific deuteration of PUFAs and analogous poly-alkenes under exceptional kinetic control. Deuterium oxide (D2O) has been identified not only as a deuterium source but also as a crucial component in the overall reaction mechanism responsible for averting the formation of thermodynamically favored side-products

  药物和生物学相关分子的选择性氘化在制药行业中变得越来越重要。多不饱和脂肪酸（PUFA）在其双烯丙基位点的位点选择性同位素增强已被认为是防止这些分子氧化损伤的一种独特方法，这种氧化损伤与神经元和视网膜疾病，动脉粥样硬化和衰老有关。用于制备位点选择性氘代PUFA的典型方法需要相当长，费力且昂贵的合成。在这份报告中，我们公开了非常有效的催化方案，用于在特殊动力学控制下对PUFA和类似聚烯烃进行位点特异性氘化。氧化氘（D 2O）不仅被认为是氘源，而且在整个反应机制中也起着至关重要的作用，该机制负责避免形成热力学上有利的副产物。
• A MIXTURE WITH STABILIZED TASTE AND/OR ODOR
  申请人：Symrise AG

  公开号：EP3777981A1

  公开（公告）日：2021-02-17

  Suggested is a mixture with stabilized taste and/or odor, comprising or consisting of: (a) [6]-paradol and (b) at least one mono- or polyunsaturated C8-C22 fatty acid or its monohydric or polyhydric C1-C18 aliphatic alcohols ester, wherein the composition comprises the component (a) in an amount from 0.0001 to 1 wt.-percent, based on the mixture.

  建议是一种具有稳定味道和/或气味的混合物，由以下物质组成或构成： (a) [6]-paradol 和 (b) 至少一种一元或多元不饱和 C8-C22 脂肪酸或其一元或多元 C1-C18 脂肪醇酯、 其中，该组合物包含的 (a) 组分的含量为 0.0001 至 1 wt.-%，以混合物为基础。
• Pharmaceutical compositions having a modified vehicle
  申请人：——

  公开号：US20040170650A1

  公开（公告）日：2004-09-02

  A composition comprising: (a) one to three bioactive agents; and (b) a vehicle comprising; (i) a modified liquid carrier, and (ii) an unmodified liquid carrier wherein the ratio by volume of the modified liquid carrier to the unmodified liquid carrier is between 0.00001:99.99999 to less than 0.01:99.99, that provide the composition with predictable sustained-release properties and wherein immediately after manufacture of the composition, said composition can be administered to a host such that the one to three bioactive agents is released to the host on a sustained basis.

  一种组合物，包括 (a) 一至三种生物活性剂；和 (b) 一种载体，包括 (i) 改性液体载体，和 (ii) 未改性液体载体 其中，改性液体载体与未改性液体载体的体积比介于 0.00001:99.99999 至小于 0.01:99.99 之间，从而使该组合物具有可预测的持续释放特性，并且在制造该组合物后，可立即将所述组合物施用到宿主体内，从而使一至三种生物活性剂持续释放到宿主体内。
• Serebrennikova,G.A. et al., Journal of general chemistry of the USSR, 1963, vol. 33, p. 54 - 56
  作者：Serebrennikova,G.A. et al.

  DOI：——

  日期：——
• Lipase-catalyzed transesterification of trilinolein or trilinolenin with selected phenolic acids
  作者：Kebba Sabally、Salwa Karboune、Richard St-Louis、Selim Kermasha

  DOI：10.1007/s11746-006-1181-3

  日期：2006.2

  AbstractThe enzymatic transesterification of selected phenolic acids with TAG, including trilinolein (TLA) and trillinolenin (TLNA), was investigated in an organic solvent medium. Maximal bioconversion of 66% was obtained with a dihydrocaffeic acid (DHCA) to TLA ratio of 1∶2 after 5 d of reaction. Similarly, the highest bioconversion of 62% was obtained with a DHCA to TLNA ratio of 1∶2, but after 12 d of reaction. However, a ratio of 1∶4 DHCA/TLA decreased the bioconversion to 53%. Transesterification reactions of ferulic acid with both TAG, using a ratio of 1∶2, resulted in low bioconversion of 16 and 14% with TLA and TLNA, respectively. The overall results indicated that bioconversion of phenolic MAG was higher than that of phenolic DAG. The structures of mono‐ and dilinoleyl dihydrocaffeate as well as those of mono‐ and dilinolenyl dihydrocaffeate were confirmed by LC‐MS analyses. The phenolic lipids demonstrated moderate radical‐scavenging activity.