Sch 72788 | 203180-40-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: Sch 72788
• 英文别名: 4-[4-[1(S)-[4-[(1,3-benzodioxol-5-yl)sulfonyl]phenyl]ethyl]-3(R)-methyl-1-piperazinyl]-4-methyl-1-(propylsulfonyl)piperidine；SCH-72788；4-(4-(1(s)-(4-((1,3-Benzodioxol-5-yl)sulfonyl)phenyl)ethyl)-3(r)-methyl-1-piperazinyl)-4-methyl-1-(propylsulfonyl)piperidine；(2R)-1-[(1S)-1-[4-(1,3-benzodioxol-5-ylsulfonyl)phenyl]ethyl]-2-methyl-4-(4-methyl-1-propylsulfonylpiperidin-4-yl)piperazine
• CAS: 203180-40-9
• 化学式: C₂₉H₄₁N₃O₆S₂
• 分子量: 591.793
• InChiKey: WHTGUJCOADGPEQ-PKTZIBPZSA-N

物化性质

• 沸点：
  701.9±70.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  113
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• MUSCARINIC COMBINATION OF A SELECTIVE M2-ANTAGONIST AND A PERIPHERAL NON-SELECTIVE ANTAGONIST FOR TREATING HYPOCHOLINERGIC DISORDERS
  申请人：Chase Pharmaceuticals Corporation

  公开号：EP3324966A1

  公开（公告）日：2018-05-30
• [EN] MUSCARINIC COMBINATION OF A SELECTIVE M2-ANTAGONIST AND A PERIPHERAL NON-SELECTIVE ANTAGONIST FOR TREATING HYPOCHOLINERGIC DISORDERS<br/>[FR] COMBINAISON MUSCARINIQUE D'UN ANTAGONISTE SÉLECTIF DU RÉCEPTEUR M2 ET D'UN ANTAGONISTE NON SÉLECTIF PÉRIPHÉRIQUE POUR LE TRAITEMENT DE TROUBLES HYPOCHOLINERGIQUES
  申请人：CHASE PHARMACEUTICALS CORP

  公开号：WO2017015349A1

  公开（公告）日：2017-01-26

  A combination of a muscarinic receptor antagonist consisting of a M2-receptor antagonist and of a non-selective, peripheral anticholinergic agent, and optionally an anticholinesterase inhibitor, and use of the same for treatment of hypocholinergic type disorders such as Alzheimer type dementia, schizophrenia, schizophrenia associated dementia, and schizoaffective disorders.
• [EN] MUSCARINIC M2-ANTAGONIST COMBINATIONS<br/>[FR] COMBINAISONS D'ANTAGONISTE MUSCARINIQUE M2
  申请人：CHASE PHARMACEUTICALS CORP

  公开号：WO2017147104A1

  公开（公告）日：2017-08-31

  A combination of a M2-receptor antagonist, a non-anticholinergic antiemetic agent, a muscarinic receptor antagonist consisting of a non-selective peripheral anticholinergic agent, and optionally an anticholinesterase inhibitor, to treat hypocholinergic disorders such as Alzheimer type dementia, schizophrenia, schizophrenia associated dementia, and schizoaffective disorders.
• [EN] MUSCARINIC M2-ANTAGONIST COMBINATION<br/>[FR] COMBINAISON D'ANTAGONISTE DE M2 MUSCARINIQUE
  申请人：CHASE PHARMACEUTICALS CORP

  公开号：WO2018039159A1

  公开（公告）日：2018-03-01

  A combination of a M2-receptor antagonist and a non-anticholinergic antiemetic agent, and optionally an anticholinesterase inhibitor, to treat hypocholinergic disorders such as Alzheimer type dementia, schizophrenia, schizophrenia associated dementia, and schizoaffective disorders.