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1-Bromo-4-methoxy-2-(2-methoxyethoxymethyl)benzene | 350601-29-5

中文名称
——
中文别名
——
英文名称
1-Bromo-4-methoxy-2-(2-methoxyethoxymethyl)benzene
英文别名
——
1-Bromo-4-methoxy-2-(2-methoxyethoxymethyl)benzene化学式
CAS
350601-29-5
化学式
C11H15BrO3
mdl
——
分子量
275.142
InChiKey
PVYWDZIURNRRIL-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    318.1±32.0 °C(Predicted)
  • 密度:
    1.321±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    2.1
  • 重原子数:
    15
  • 可旋转键数:
    6
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.45
  • 拓扑面积:
    27.7
  • 氢给体数:
    0
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    1-Bromo-4-methoxy-2-(2-methoxyethoxymethyl)benzene正丁基锂草酰氯 、 tris(dibenzylideneacetone)dipalladium (0) 、 三叔丁基膦二异丁基氢化铝二甲基亚砜三乙胺 、 cesium fluoride 作用下, 以 四氢呋喃正己烷二氯甲烷 为溶剂, 反应 16.08h, 生成 2,6-二-[4-甲氧基-2-(2-甲氧基-乙氧基甲基)-苯基]-吡啶-4-甲醛
    参考文献:
    名称:
    Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors
    摘要:
    Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tet.2004.08.049
  • 作为产物:
    描述:
    2-溴-5-甲氧基甲苯N-溴代丁二酰亚胺(NBS)偶氮二异丁腈 、 sodium hydride 作用下, 以 四氢呋喃 为溶剂, 反应 19.0h, 生成 1-Bromo-4-methoxy-2-(2-methoxyethoxymethyl)benzene
    参考文献:
    名称:
    Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors
    摘要:
    Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tet.2004.08.049
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文献信息

  • Dual-Signaling Fluorescent Chemosensors Based on Conformational Restriction and Induced Charge Transfer
    作者:Jesse V. Mello、Nathaniel S. Finney
    DOI:10.1002/1521-3773(20010417)40:8<1536::aid-anie1536>3.0.co;2-r
    日期:2001.4.17
    Twist and shout! By restricting conformation, 2,6-biarylpyridines can be induced to "speak" to us through increased fluorescence emission. In combination with induced charge transfer, this allows these simple fluorophores to reveal otherwise silent binding events to alkali metal and alkaline earth cations through brightening and color change (see picture; from left to right: no metal, Li+ , Mg2+ ,
    扭曲和喊叫!通过限制构象,可以通过增加的荧光发射来诱导2,6-联芳基吡啶对我们“说话”。结合感应的电荷转移,这使这些简单的荧光团可以通过增亮和颜色变化来揭示与碱金属和碱土金属阳离子的其他沉默结合事件(参见图片;从左至右:无金属,Li +,Mg 2+和Ca 2+)。
  • [EN] ARYLPYRIDINE COMPOUNDS<br/>[FR] COMPOSES D'ARYLPYRIDINE
    申请人:UNIV CALIFORNIA
    公开号:WO2004046103A3
    公开(公告)日:2005-02-24
  • Exploiting the Versatile Assembly of Arylpyridine Fluorophores for Wavelength Tuning and SAR
    作者:Albert G. Fang、Jesse V. Mello、Nathaniel S. Finney
    DOI:10.1021/ol0272287
    日期:2003.4.1
    [GRAPHICS]The facile modular assembly of polyarylpyridine fluorophores provides two important advantages in the development of fluorescent chemosensors: it allows rapid dissection of the structural requirements for fluorescent chemosensing and it allows dramatic tuning of emission wavelength by changes in a substituent remote from the binding site.
  • Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors
    作者:A.G. Fang、J.V. Mello、N.S. Finney
    DOI:10.1016/j.tet.2004.08.049
    日期:2004.11
    Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.
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