(2E,4E)-5-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]penta-2,4-dienamide | 1204306-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (2E,4E)-5-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]penta-2,4-dienamide
• 英文别名: Ptn9ljl6PY
• CAS: 1204306-34-2
• 化学式: C₁₉H₁₆BrN₃O
• 分子量: 382.26
• InChiKey: IVAUEQVCSQZMGV-QIUCFAMLSA-N

物化性质

• 沸点：
  608.8±55.0 °C(Predicted)
• 密度：
  1.382±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel Inhibitors of Proliferation and Activation of Signal Transducer and Activator of Transcription (STATS)
  申请人：Priebe Waldemar

  公开号：US20110053992A1

  公开（公告）日：2011-03-03

  Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

  提供有效调节STAT3和/或STAT5激活的吡啶化合物，可用于预防和治疗增生性疾病和病症，包括癌症、炎症和增生性皮肤疾病。
• NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATORS OF TRANSCRIPTION (STATS)
  申请人：Priebe Waldemar

  公开号：US20120149738A1

  公开（公告）日：2012-06-14

  Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

  提供了能够有效调节STAT3和/或STAT5激活的吡啶化合物，可用于预防和治疗增生性疾病和病症，包括癌症、炎症和增生性皮肤疾病。
• NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STATS)
  申请人：Board of Regents, The University of Texas System

  公开号：US20140228414A1

  公开（公告）日：2014-08-14

  Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

  提供了在调节STAT3和/或STAT5激活方面有效的吡啶化合物，这些化合物在预防和治疗增生性疾病和病症中包括癌症、炎症和增生性皮肤疾病方面具有用处。
• INTERFERON THERAPIES IN COMBINATION WITH BLOCKADE OF STAT3 ACTIVATION
  申请人：Board of Regents, The University of Texas System

  公开号：EP2506852A2

  公开（公告）日：2012-10-10
• Methods of Treating Skin Disorders with Caffeic Acid Analogs
  申请人：Priebe Waldemar

  公开号：US20100152143A1

  公开（公告）日：2010-06-17

  Embodiments of the invention generally relate to pharmaceutical compositions containing at least one caffeic acid compound and methods for the topical treatment of proliferative and inflammatory skin disorders such as plaque psoriasis, atopic dermatitis, and other disorders. In some embodiments, the topical treatment includes applications of the pharmaceutical composition containing at least one caffeic acid compound or a mixture of caffeic acid compounds such as caffeic acid ester compounds, caffeic acid amide compounds, analogues thereof, derivatives thereof, salts thereof, or mixtures thereof. The pharmaceutical composition or topical dosage may contain the caffeic acid compound at a concentration by weight within a range from about 0.01% to about 20%, preferably, from about 0.1% to about 15%, preferably, from about 1% to about 10%, more preferably, from about 3% to about 7%, and more preferably, from about 4% to about 6%.