dihydrotestosterone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: dihydrotestosterone
• 英文别名: Dihydrotestosteron；17β-Hydroxy-androstan-3-on；Androstan-17β-ol-3-on；(10S,13S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₁₉H₃₀O₂
• 分子量: 290.446
• InChiKey: NVKAWKQGWWIWPM-YIIIWSPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dihydrotestosterone 在 碘酸 、 二甲基亚砜 作用下， 反应 12.0h， 以92%的产率得到17-Hydroxy-androst-1-en-3-on
  参考文献：
  名称：

  HIO3 and I2O5: Mild and Selective Alternative Reagents to IBX for the Dehydrogenation of Aldehydes and Ketones

  摘要：

  DOI：

  10.1002/1521-3773(20020415)41:8<1386::aid-anie1386>3.0.co;2-v

文献信息

• NOVEL METHOD FOR THE DIASTEREOSELECTIVE PRODUCTION OF A CHIRAL PRIMARY AMINE ON A STEROID
  申请人：ODDON Gilles

  公开号：US20100069627A1

  公开（公告）日：2010-03-18

  The invention relates to a diastereoselective method for obtaining a primary amine on a steroid, comprising the reduction of an oxime by lithium in ammonia at a low temperature in an ether/alcohol mixture.

  该发明涉及一种在类固醇上获得主要胺的对映选择性方法，包括在醚/醇混合物中低温下用氨基锂还原肟。
• PROGESTERONE RECEPTOR ANTAGONISTS AND USES THEREOF
  申请人：Rafestin-Oblin Marie-Edith

  公开号：US20130203718A1

  公开（公告）日：2013-08-08

  The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.

  本发明涉及一种化合物，其化学式为（I）：用作孕激素受体拮抗剂，特别是用于预防和/或治疗癌症或子宫病理学的用途。
• Immobilization of ArRMut11 omega-transaminase for increased operational stability and reusability in the synthesis of 3α-amino-5α-androstan-17β-ol
  作者：Nevena Kaličanin、Gordana Kovačević、Milica Spasojević、Olivera Prodanović、Suzana Jovanović-Šanta、Dušan Škorić、Dejan Opsenica、Radivoje Prodanović

  DOI：10.1016/j.procbio.2022.08.016

  日期：2022.10
• Cosmetic/dermatological applications of PPAR receptor activators
  申请人：Jomard Andre

  公开号：US20070065471A1

  公开（公告）日：2007-03-22

  Cosmetic/pharmaceutical compositions useful for regulating the size of sebaceous glands and, in particular, for inhibiting sebum production, or for treating pathologies entailing an overproduction of sebum, or for treating greasy skin and/or a scalp prone to dandruff, contain thus effective amounts of at least one activator of PPAR type receptors.
• COUMARIN-MODIFIED ANDROGENS FOR THE TREATMENT OF PROSTATE CANCER
  申请人：Health Research, Inc.

  公开号：US20220218722A1

  公开（公告）日：2022-07-14

  Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.