(2R)-2-propyloctanoic acid, sodium salt | 848899-76-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R)-2-propyloctanoic acid, sodium salt
• 英文别名: sodium;(2R)-2-propyloctanoate
• CAS: 848899-76-3
• 化学式: C₁₁H₂₁O₂*Na
• 分子量: 208.276
• InChiKey: UTCWLXGGADHOGW-HNCPQSOCSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.87
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (R)-2-丙基辛酸 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成 (2R)-2-propyloctanoic acid, sodium salt
  参考文献：
  名称：

  DRUG CONTAINING (2R)-2-PROPYLOCTANOIC ACID AS THE ACTIVE INGREDIENT

  摘要：

  公开号：

  EP1669065B1

文献信息

• INFUSION PREPARATION CONTAINING (2R)-2-PROPYLOCTANOIC ACID AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1669066A1

  公开（公告）日：2006-06-14

  The present invention relates to an infusion preparation which is useful for neurodegenerative diseases, which comprises (2R)-2-propyloctanoic acid or a salt thereof and a basic metal ion which is supplied from a metal salt or a metal hydroxide of weak acid, preferably about 1 to about 5 equivalents of a basic metal ion based on 1 equivalent of (2R)-2-propyloctanoic acid or a salt thereof, and optionally further comprises other infusion components. The infusion preparation of the present invention is has a pH appropriate for intravenous administration, and is useful for intravenous administration since it does not require any preparative operation such as dissolution, dilution or the like at the time of use.

  本发明涉及一种适用于神经退行性疾病的输液制剂，它包括(2R)-2-丙辛酸或其盐和碱性金属离子，碱性金属离子由金属盐或弱酸性金属氢氧化物提供，优选以1当量的(2R)-2-丙辛酸或其盐为基础提供约1至约5当量的碱性金属离子，并可选择地进一步包括其他输液成分。本发明的输液制剂具有适合静脉给药的 pH 值，由于在使用时不需要进行溶解、稀释等任何制备操作，因此适用于静脉给药。
• CAPSULE STABLE AGAINST MASTICATION
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1754479A1

  公开（公告）日：2007-02-21

  The present invention relates to a soft capsule which is easily disintegrated in the stomach, wherein the contents thereof are not easily leaked at the time of mastication, which is obtained by providing a soft capsule comprising (2R)-2-propyloctanoic acid or a salt thereof with at least one property, preferably all properties, selected from (A) wherein it has a strength of 150 to 400 N by a cracking test; (B) wherein it has a disintegration time of 3 to 10 minutes by the disintegration test stipulated in Japanese Pharmacopoeia; (C) wherein the capsule shell has a shell thickness of 0.05 to 0.50 mm; (D) wherein the capsule shell has a first seam thickness of 0.10 to 0.55 mm; (E) wherein the capsule shell has a second seam thickness of 0.05 to 0.50 mm; (F) wherein the capsule shell has a water content of 5.0 to 9.0%.

  本发明涉及一种在胃中易于崩解的软胶囊，其内容物在咀嚼时不易泄漏，该软胶囊是通过提供一种软胶囊而获得的，该软胶囊包含(2R)-2-丙辛酸或其盐，该软胶囊具有至少一种特性，最好是所有特性，这些特性选自 (A) 根据开裂试验，其强度为 150 至 400 N；(B) 根据日本药典规定的崩解试验，其崩解时间为 3 至 10 分钟； (C) 胶囊壳的厚度为 0.(D) 其中胶囊壳的第一接缝厚度为 0.10 至 0.55 毫米； (E) 其中胶囊壳的第二接缝厚度为 0.05 至 0.50 毫米； (F) 其中胶囊壳的含水量为 5.0 至 9.0%。
• CRYSTAL COMPRISING (2R)-2-PROPYLOCTANOIC ACID AND DIBENZYLAMINE
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1741697B1

  公开（公告）日：2012-12-19
• EP3520795
  申请人：——

  公开号：——

  公开（公告）日：——
• Infusion preparation containing (2r)-2-propyloctanoic acid as at the active ingredient
  申请人：Sudoh Masao

  公开号：US20070066686A1

  公开（公告）日：2007-03-22

  The present invention relates to an infusion preparation which is useful for neurodegenerative diseases, which comprises (2R)-2-propyloctanoic acid or a salt thereof and a basic metal ion which is supplied from a metal salt or a metal hydroxide of weak acid, preferably about 1 to about 5 equivalents of a basic metal ion based on 1 equivalent of (2R)-2-propyloctanoic acid or a salt thereof, and optionally further comprises other infusion components. The infusion preparation of the present invention is has a pH appropriate for intravenous administration, and is useful for intravenous administration since it does not require any preparative operation such as dissolution, dilution or the like at the time of use.