4-[4-(phenyl-sulphonamido)phenyl]butyric acid | 129948-69-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-(phenyl-sulphonamido)phenyl]butyric acid
• 英文别名: 4-[4-(Benzenesulfonylamino)-phenyl]-butyric Acid；4-(4-Phenylsulfonamido)Phenylbutyric Acid；4-[4-(benzenesulfonamido)phenyl]butanoic acid
• CAS: 129948-69-2
• 化学式: C₁₆H₁₇NO₄S
• 分子量: 319.381
• InChiKey: LLCKMHASBLSYBE-UHFFFAOYSA-N

物化性质

• 沸点：
  518.4±52.0 °C(Predicted)
• 密度：
  1.336±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-[4-(phenyl-sulphonamido)phenyl]butyric acid 在 甲醇 、 camphor-10-sulfonic acid 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-Hydroxy-4-[4-(benzenesulfonylamino)-phenyl]-butanamide
  参考文献：
  名称：

  Design and synthesis of a novel class of histone deacetylase inhibitors

  摘要：

  Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00552-2
• 作为产物：
  描述：

  4-(4-氨基苯基)丁酸 在 盐酸 、 lithium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 4-[4-(phenyl-sulphonamido)phenyl]butyric acid
  参考文献：
  名称：

  Design and synthesis of a novel class of histone deacetylase inhibitors

  摘要：

  Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00552-2

文献信息

• Compositions for the delivery of antigens
  申请人：Emisphere Technologies, Inc.

  公开号：US05958457A1

  公开（公告）日：1999-09-28

  The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.

  本发明涉及用于口服给药抗原的组合物和方法。将抗原和佐剂与酰化氨基酸或聚氨基酸以及磺化氨基酸或聚氨基酸或上述化合物的盐结合。
• Sulphonamido containing phenylalkanoic acids as thromboxane A.sub.2
  申请人：Smith Kline & French Laboratories Ltd.

  公开号：US05280043A1

  公开（公告）日：1994-01-18

  Phenylalkanoic acids containing a sulphonamido group, and their use in a method of treatment of thromboxane-A.sub.2 mediated diseases are disclosed. A compound of the invention is 4-[4-(phenyl-sulphonamido)phenyl]butyric acid.

  含有磺胺基的苯基烷酸，以及它们在治疗血栓素A.sub.2介导的疾病的方法中的应用被揭示。该发明的化合物是4-[4-(苯基磺胺基)苯基]丁酸。
• 一类苯磺酰胺苯丁酸鬼臼毒素酯类衍生物的合成及在抗癌药物中的应用
  申请人：济宁市第一人民医院

  公开号：CN113214281B

  公开（公告）日：2022-05-17

  本发明苯磺酰胺苯丁酸鬼臼毒素羧酸酯类衍生物及其合成方法和应用属于化学制药技术领域，具体涉及一类鬼臼毒素衍生物及其在肿瘤抑制方面的应用。通过合成手段将相应苯磺酰胺苯丁酸与鬼臼毒素连接，获得相应酯类衍生物，体外抗肿瘤的活性研究表明，这类鬼臼毒素羧酸酯类衍生物对肿瘤细胞株有很强的抑制活性。
• [EN] INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] INHIBITEURS DE L'HISTONE DEACETYLASE
  申请人：METHYLGENE INC

  公开号：WO2001038322A1

  公开（公告）日：2001-05-31

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病状的组合物和方法。
• Inhibitors of histone deacetylase
  申请人：MethylGene, Inc.

  公开号：US06541661B1

  公开（公告）日：2003-04-01

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶的技术。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增生性疾病和病状的组合物和方法。