L-Lysyl-L-lysinamide | 134276-59-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Lysyl-L-lysinamide
• 英文别名: (2S)-2,6-diamino-N-[(2S)-1,6-diamino-1-oxohexan-2-yl]hexanamide
• CAS: 134276-59-8
• 化学式: C₁₂H₂₇N₅O₂
• 分子量: 273.38
• InChiKey: UELKIOISOHAUNP-UWVGGRQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  150
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• USE OF CATIONIC LIPIDS FOR INTRACELLULAR PROTEIN DELIVERY
  申请人：Gene Therapy Systems, Inc.

  公开号：EP1237581A1

  公开（公告）日：2002-09-11
• Bmp Gene and Fusion Protein
  申请人：Hidaka Chisa

  公开号：US20080260829A1

  公开（公告）日：2008-10-23

  This invention relates to BMP fusion genes, BMP fusion proteins. The invention further relates to methods for treatment using BMP fusion genes and BMP fusion proteins. Additionally, the invention relates to BMP fusion gene and BMP fusion protein pharmaceutical compositions.
• [EN] USE OF CATIONIC LIPIDS FOR INTRACELLULAR PROTEIN DELIVERY<br/>[FR] UTILISATION DE LIPIDES CATIONIQUES POUR ADMINISTRATION DE PROTEINES INTRACELLULAIRES
  申请人：GENE THERAPY SYSTEMS INC

  公开号：WO2001043778A1

  公开（公告）日：2001-06-21

  The present invention relates to compositions and methods for intracellular protein delivery. The compositions include a protein operatively associated with a cationic lipid in such a way as to facilitate intracellular delivery of the protein by the cationic lipid, such as by associating directly with a cationic lipid, encapsulating it in a cationic liposome, associating the protein with a lipoplex comprising cationic lipid and nucleic acid, or associating the protein with an anionic polymer that is in association with a cationic lipid. These compositions are useful in delivering antibodies to intracellular proteins to neutralize their activity, and to introduce therapeutically useful proteins, peptides or small molecules.