1,4-Bis-methyl-aminomethyl-benzol | 13093-02-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-Bis-methyl-aminomethyl-benzol
• 英文别名: N,N'-dimethyl-p-xylylenediamine；N-methyl-1-[4-(methylaminomethyl)phenyl]methanamine
• CAS: 13093-02-2
• 化学式: C₁₀H₁₆N₂
• mdl: MFCD20542364
• 分子量: 164.25
• InChiKey: JVGKCYRIXCBMPD-UHFFFAOYSA-N

物化性质

• 沸点：
  141 °C(Press: 155 Torr)
• 密度：
  0.951±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-Bis-methyl-aminomethyl-benzol 在 lithium aluminium tetrahydride 作用下， 以 1,4-二氧六环 、 三乙胺 、 苯 为溶剂， 反应 30.0h， 生成 N,N',N'',N'''-tetramethyl-2,11,20,29-tetraaza<3.3.3.3>paracyclophane
  参考文献：
  名称：

  Substrate specificity in ester hydrolysis by a new water-soluble heterocyclophane

  摘要：

  DOI：

  10.1021/ja00411a037
• 作为产物：
  描述：

  N,N'-(p-phenylenedimethylidyne)-bis(methylamine) 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以2.128 g的产率得到1,4-Bis-methyl-aminomethyl-benzol
  参考文献：
  名称：

  Anion-driven conformation control and enhanced sulfate binding utilising aryl linked salicylaldoxime dicopper helicates

  摘要：

  本文描述了利用新的1,4-芳基间隔物对“纯金属”和阴离子包裹的双螺旋二铜（II）进行的综合和光谱分析。对复合物的X射线晶体学分析表明，芳族间隔物增加了复合物的刚性，但复合物仍能够发生剧烈的“卷曲”以结合阴离子。光谱分析表明，SO42−的结合强度明显高于非配位阴离子ClO4−、NO3−和Br−，这归因于复合物刚性的增强以及复合物与二阴离子之间静电相互作用增强的共同作用。

  DOI：

  10.1039/c1dt10808e

文献信息

• Selective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium‐Catalyzed Borrowing Hydrogen Pathway
  作者：Jaeyoung Jeong、Ken‐ichi Fujita

  DOI：10.1002/cctc.202101499

  日期：2022.2.8

  A new system for the selective synthesis of bisdimethylamine derivatives using diols and aqueous dimethylamine as the starting materials was developed. An iridium complex bearing an N-heterocyclic carbene ligand was used as the catalyst, and the reaction proceeded based on the borrowing hydrogen strategy in an aqueous medium under mild conditions. Various bisdimethylamine derivatives were obtained

  开发了一种以二醇和二甲胺水溶液为原料选择性合成二甲胺衍生物的新系统。以带有N-杂环卡宾配体的铱配合物为催化剂，反应在温和条件下在水介质中基于借氢策略进行。以良好至极好的收率获得了各种双二甲胺衍生物。
• Local anesthetic compounds and uses
  申请人：Advanced Medicine, Inc.

  公开号：US06337423B1

  公开（公告）日：2002-01-08

  Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.

  本发明揭示了用于产生长时期局部麻醉的新化合物、药物组合物和方法。本发明的化合物是多结合化合物，包括从2到10个配体共价连接到一个或多个连接物的结构，每个配体能够结合到电压门控Na+通道中的一个配体结合位点，以调节其生物过程/功能。
• Alkaline-Earth-Catalysed Cross-Dehydrocoupling of Amines and Hydrosilanes: Reactivity Trends, Scope and Mechanism
  作者：Clément Bellini、Vincent Dorcet、Jean-François Carpentier、Sven Tobisch、Yann Sarazin

  DOI：10.1002/chem.201504316

  日期：2016.3.18

  Alkaline‐earth (Ae=Ca, Sr, Ba) complexes are shown to catalyse the chemoselective cross‐dehydrocoupling (CDC) of amines and hydrosilanes. Key trends were delineated in the benchmark couplings of Ph3SiH with pyrrolidine or tBuNH2. AeE(SiMe3)2}2⋅(THF)x (E=N, CH; x=2–3) are more efficient than N^N}AeE(SiMe3)2}⋅(THF)n (E=N, CH; n=1–2) complexes (where N^N}−=ArN(o‐C6H4)C(H)=NAr}− with Ar=2,6‐iPr2‐C6H3)

  碱土（Ae = Ca，Sr，Ba）配合物可催化胺和氢硅烷的化学选择性交叉脱氢偶联（CDC）。在Ph 3 SiH与吡咯烷或t BuNH 2的基准偶联中描述了关键趋势。阂E（森达3）2 } 2 ⋅（THF）X（E = N，CH; X = 2〜3）比更有效N ^ N} 阂E（森达3）2 } ⋅（THF）n（E = N，CH; n = 1–2）个络合物（其中N ^ N} - = ArN（o -C 6 H 4）C（H）= NAr}− Ar = 2,6 - i Pr 2– C 6 H 3）带有亚氨基苯胺配体，烷基预催化剂比酰胺类似物更好。周转频率（TOF）以Ca 30种产品）包括二胺和二（氢硅烷）。对吡咯烷和Ph 3 SiH的Ba促进的CDC的动力学分析表明：1）动力学规律为速率= k [Ba] 1 [胺] 0 [氢硅烷] 1，2）芳基氢硅烷上的吸电子p取代基可提高反应速率，并且3）对于Ph
• CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING
  申请人：Reiley Pharmaceuticals, Inc.

  公开号：US20150374858A1

  公开（公告）日：2015-12-31

  Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.

  披露了来自非甾体抗炎药（NSAIDs）的衍生物及其使用方法，这对于识别和定位患者疼痛感觉的病理和/或炎症部位；识别原发、继发、良性或恶性肿瘤的部位；以及诊断感染或确认或排除疑似感染非常有用。基于NSAID的偶联物含有成像基团。这些偶联物在环氧化酶表达增加的部位富集，从而揭示了前列腺素产生增加的部位，这与疼痛和炎症有关，并与肿瘤存在和/或位置有关。识别COX表达增加的区域也有助于筛查感染。
• Dental obturator point
  申请人：Dentsply DeTrey GmbH

  公开号：EP1911433A1

  公开（公告）日：2008-04-16

  Dental obturator point having an obturation body of a material comprising (a) a polymer blend comprising (a1) 5 to 95 wt% based on the total amount of the polymer blend of a thermoplastic epoxide amine addition polymer, and (a2) 95 to 5 wt% based on the total blend of a high performance polymer; and (b) an particulate-filler; whereby the obturation body has a radio opacity of at least 3 mm/mm Al.

  牙科封堵点具有由材料组成的封堵体，包括(a)聚合物混合物，包括(a1)热塑性环氧胺加成聚合物，其占聚合物混合物总量的5至95重量％，以及(a2)高性能聚合物，其占总混合物的95至5重量％；和(b)颗粒填料；使得封堵体的射线不透明度至少为3毫米/毫米铝。