N-(1,1-Dimethylethyl)-2-hydroxypropanamide | 69727-14-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(1,1-Dimethylethyl)-2-hydroxypropanamide
• 英文别名: N-t-butyl-2-hydroxypropanamide；N-tert-butyl-lactamide；DL-Milchsaeure-tert-butylamid；N-tert-Butyl-lactamid；N-(tert-butyl)-2-hydroxypropanamide；N-tert-butyl-2-hydroxypropanamide
• CAS: 69727-14-6
• 化学式: C₇H₁₅NO₂
• 分子量: 145.202
• InChiKey: DLZIWUSVVGVHNK-UHFFFAOYSA-N

物化性质

• 沸点：
  280.4±23.0 °C(Predicted)
• 密度：
  0.981±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1,1-Dimethylethyl)-2-hydroxypropanamide 生成 N-t-butyl-2-benzoyloxypropanemide
  参考文献：
  名称：

  A New Reaction of Nitriles. VI. Unsaturated Amides¹

  摘要：

  DOI：

  10.1021/ja01153a005
• 作为产物：
  描述：

  3-t-butyl-2-(dimethylamino)-5-methyloxazolidin-4-one 以23%的产率得到
  参考文献：
  名称：

  DANGELI, FERRUCCIO;CAVICCHIONI, GIORGIO;CATELANI, GIORGIO;MARCHETTI, PAOL+, GAZZ. CHIM. ITAL., 119,(1989) N, C. 471-474

  摘要：

  DOI：

文献信息

• D'Angeli, Ferrucio; Cavicchioni, Giorgio; Catelani, Giorgio, Gazzetta Chimica Italiana, 1989, vol. 119, # 9, p. 471 - 474
  作者：D'Angeli, Ferrucio、Cavicchioni, Giorgio、Catelani, Giorgio、Marchetti, Paolo、Maran, Flavio

  DOI：——

  日期：——
• Inexpensive reagents for the synthesis of amides from esters and for regioselective opening of epoxides
  作者：A. Solladie-Cavallo、M. Bencheqroun

  DOI：10.1021/jo00048a011

  日期：1992.10

  Lithium aluminum amides [LiAl(NHR)4], 6a-6d, easily prepared in Et2O or THF from 1 equiv of LiAlH4 and 5 equiv of amine, proved to be efficient reagents for the synthesis of secondary amides from esters (approximately 100% with unhindered amines and 92% with tBuNH2). They also open aryl epoxides with very high regioselectivity to give 97-98% of the beta-amino-alpha-arylethanols (corresponding to the SN2 mechanism).
• INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20210070698A1

  公开（公告）日：2021-03-11

  The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.
• A New Reaction of Nitriles. VI. Unsaturated Amides¹
  作者：Herman Plaut、John J. Ritter

  DOI：10.1021/ja01153a005

  日期：1951.9
• DANGELI, FERRUCCIO;CAVICCHIONI, GIORGIO;CATELANI, GIORGIO;MARCHETTI, PAOL+, GAZZ. CHIM. ITAL., 119,(1989) N, C. 471-474
  作者：DANGELI, FERRUCCIO、CAVICCHIONI, GIORGIO、CATELANI, GIORGIO、MARCHETTI, PAOL+

  DOI：——

  日期：——